Preview

Medical alphabet

Advanced search
Open Access Open Access  Restricted Access Subscription or Fee Access

The prevalence of falsification of biologically active additives popular among athletes: a scoping review

https://doi.org/10.33667/2078-5631-2023-29-41-47

Abstract

Dietary supplements are widely used by athletes, but many may not be aware of their falsification, especially when you consider that supplements can often be contaminated with prohibited substances.

Objective. To analyze and summarize information on the prevalence of falsification of dietary supplements.

Methods. To analyze the research, we searched the following scientific electronic databases: PubMed, Science Direct, MedNar and eLibrary without language restrictions. The review included studies published over the past 25 years.

Results. According to the search results, we found 271 studies and a total of 36 studies were included in the review.

Conclusions. From 10 to 58% of biologically active additives may be contaminated with prohibited substances. The most common substances in them are anabolic–androgenic steroids and stimulants.

About the Authors

А. В. Miroshnikov
Russian University of Sports ‘GTSOLIFK’
Russian Federation

Miroshnikov Alexander B., Dr Bio Sci, associate professor, professor of the Dept of Sports Medicine, dean of the Faculty of Adaptive Physical Culture, Recreation and Tourism

Moscow



P. D. Rybakova
Center for Sports Innovative Technologies and training of National Teams
Russian Federation

Rybakova Polina D., sports nutritionist

Moscow



A. V. Meshtel
Russian University of Sports ‘GTSOLIFK’
Russian Federation

Meshtel Alexander V., postgraduate student of the Dept of Sports Medicine, assistant of the Dept of Anatomy and Biological Anthropology

Moscow



References

1. Myoenzono K, Yasuda J, Takai E, Shinagawa A, Kaneko N, Yoshizaki T, Namma-Motonaga K, Yoshino M, Kondo E, Nakajima K, Hangai M, Kamahara K, Kamihigashi E, Kusano S, Kamei A. Investigation of supplement use and knowledge among Japanese elite athletes for the Tokyo 2020 Olympic/Paralympic games and the Beijing 2022 winter Olympic/Paralympic games. Front. Sports Act. 2023; (5): 1258542. DOI: 10.3389/ fspor.2023.1258542

2. Maughan RJ. Contamination of dietary supplements and positive drug tests in sport. J. Sports Sci. 2005; (9): 883–9. DOI: 10.1080/02640410400023258

3. Kozhuharov VR, Ivanov K, Ivanova S. Dietary Supplements as Source of Unintentional Doping. Biomed Res Int. 2022; (2022): 8387271. DOI: 10.1155/2022/8387271

4. Molina Juan L, Sospedra I, Perales A, González-Díaz C, Gil-Izquierdo A, Martínez-Sanz JM. Analysis of health claims regarding creatine monohydrate present in commercial communications for a sample of European sports foods supplements. Public Health Nutr. 2021; (20): 1–9. DOI: 10.1017/S1368980020005121

5. Ferrando AA, Wolfe RR, Hirsch KR, Church DD, Kviatkovsky SA, Roberts MD, Stout JR, Gonzalez DE, Sowinski RJ, Kreider RB, Kerksick CM, Burd NA, Pasiakos SM, Ormsbee MJ, Arent SM, Arciero PJ, Campbell BI, VanDusseldorp TA, Jager R, Willoughby DS, Kalman DS, Antonio J. International Society of Sports Nutrition Position Stand: Effects of essential amino acid supplementation on exercise and performance. J. Int Soc Sports Nutr. 2023; 20(1): 2263409. DOI: 10.1080/15502783.2023.2263409

6. Morgado A, Tsampoukas G, Sokolakis I, Schoentgen N, Urkmez A, Sarikaya S. Do «testosterone boosters» really increase serum total testosterone? A systematic review. Int J. Impot Res. 2023; (1). DOI: 10.1038/s41443–023–00763–9

7. Lauritzen F, Gjelstad A. Trends in dietary supplement use among athletes selected for doping controls. Front Nutr. 2023; (10): 1143187. DOI: 10.3389/fnut.2023.1143187

8. Tricco AC, Lillie E, Zarin W, O’Brien KK, Colquhoun H, Levac D, Moher D, Peters MDJ, Horsley T, Weeks L, Hempel S, Akl EA, Chang C, McGowan J, Stewart L, Hartling L, Aldcroft A, Wilson MG, Garritty C, Lewin S, Godfrey CM, Macdonald MT, Langlois EV, Soares-Weiser K, Moriarty J, Clifford T, Tunçalp Ö, Straus SE. PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation. Ann Intern Med. 2018; 169 (7): 467–473. DOI: 10.7326/M18–0850

9. Gurley BJ, Wang P, Gardner SF. Ephedrine-type alkaloid content of nutritional supplements containing Ephedra sinica (Ma-huang) as determined by high performance liquid chromatography. 1998; 87 (12): 1547–53. DOI: 10.1021/js9801844

10. Green GA, Catlin DH, Starcevic B. Analysis of over-the-counter dietary supplements. Clin. J. Sport Med. 2001; 11 (4): 254–9. DOI: 10.1097/00042752–200110000–00008

11. Zhang Y, Woods RM, Breitbach ZS, Armstrong DW. 1, 3-dimethylamylamine (DMAA) in supplements and geranium products: natural or synthetic? Drug Test Anal. 2012; 4 (12): 986–90. DOI: 10.1002/dta.1368

12. Austin KG, Travis J, Pace G, Lieberman HR. Analysis of 1, 3 dimethylamylamine concentrations in Geraniaceae, geranium oil and dietary supplements. Drug Test Anal. 2014; 6 (7–8): 797–804. DOI: 10.1002/dta.1491

13. Cohen PA, Maller G, DeSouza R, Neal-Kababick J. Presence of banned drugs in dietary supplements following FDA recalls. JAMA. 2014; 312 (16): 1691–3. DOI: 10.1001/ jama.2014.10308

14. Cohen PA, Travis JC, Venhuis BJ. A methamphetamine analog (N, α-diethyl-phenylethylamine) identified in a mainstream dietary supplement. Drug Test Anal. 2014; 6 (7–8): 805–7. DOI: 10.1002/dta.1578

15. ElSohly MA, Gul W. LC–MS-MS analysis of dietary supplements for N-ethyl-α-ethyl-phenethylamine (ETH), N, N-diethylphenethylamine and phenethylamine. J. Anal. Toxicol. 2014; 38 (2): 63–72. DOI: 10.1093/jat/bkt097

16. Cohen PA, Travis JC, Venhuis BJ. A synthetic stimulant never tested in humans, 1,3-dimethylbutylamine (DMBA), is identified in multiple dietary supplements. Drug Test Anal. 2015; 7 (1): 83–7. DOI: 10.1002/dta.1735

17. Attipoe S, Cohen PA, Eichner A, Deuster PA. Variability of stimulant levels in nine sports supplements over a 9-month period. Int J. Sport Nutr Exerc Metab. 2016; 26 (5): 413–20. DOI: 10.1123/ijsnem.2015–0177

18. Cohen PA, Bloszies C, Yee C, Gerona R. An amphetamine isomer whose efficacy and safety in humans has never been studied, β-methylphenylethylamine (BMPEA), is found in multiple dietary supplements. Drug Test Anal. (2016) 8 (3–4): 328–33. DOI: 10.1002/dta.1793

19. Cohen PA, Avula B, Venhuis B, Travis JC, Wang YH, Khan IA. Pharmaceutical doses of the banned stimulant oxilofrine found in dietary supplements sold in the USA. Drug Test Anal. 2017; 9 (1): 135–42. DOI: 10.1002/dta.1976

20. Cohen PA, Travis JC, Keizers PH, Boyer FE, Venhuis BJ. The stimulant higenamine in weight loss and sports supplements. Clin. Toxicol (Phila). 2019; 57 (2): 125–30. DOI: 10.1080/15563650.2018.1497171

21. Cohen PA, Travis JC, Keizers PH, Deuster P, Venhuis BJ. Four experimental stimulants found in sports and weight loss supplements: 2-amino 6-methylheptane (octodrine), 1, 4-dimethylamylamine (1, 4-DMAA), 1, 3-dimethylamylamine (1, 3-DMAA) and 1, 3-dimethylbutylamine (1, 3-DMBA). Clin Toxicol. 2018; 56 (6): 421–6. DOI: 10.1080/15563650.2017.1398328

22. Cohen PA, Wen A, Gerona R. Prohibited stimulants in dietary supplements after enforcement action by the US food and drug administration. JAMA Intern Med. 2018; 178 (12): 1721–3. DOI: 10.1001/jamainternmed.2018.4846

23. Zhao J, Wang M, Avula B, Khan IA. Detection and quantification of phenethylamines in sports dietary supplements by NMR approach. J Pharm Biomed Anal. 2018; 151: 347–55. DOI: 10.1016/j.jpba.2018.01.025

24. Avula B, Bae JY, Chittiboyina AG, Wang YH, Wang M, Khan IA. Liquid chromatography-quadrupole time of flight mass spectrometric method for targeted analysis of 111 nitrogen-based compounds in weight loss and ergogenic supplements. J. Pharm. Biomed Anal. 2019; 174: 305–23. DOI: 10.1016/j.jpba.2019.05.066–

25. Cohen PA, Sharfstein J, Kamugisha A, Vanhee C. Analysis of ingredients of supplements in the national institutes of health supplement database marketed as containing a novel alternative to anabolic steroids. JAMA Netw Open. 2020; 3 (4): e202818. DOI: 10.1001/jamanetworkopen.2020.2818

26. Cohen PA, Zakharevich I, Gerona R. Presence of piracetam in cognitive enhancement dietary supplements. JAMA Intern Med. 2020; 180 (3): 458–9. DOI: 10.1001/jamainternmed.2019.5507

27. Cohen PA, Avula B, Wang YH, Zakharevich I, Khan I. Five unapproved drugs found in cognitive enhancement supplements. Neurol. Clin. Pract. 2021; 11 (3): e303–7. DOI: 10.1212/CPJ.0000000000000960.

28. Cohen PA, Travis JC, Vanhee C, Ohana D, Venhuis BJ. Nine prohibited stimulants found in sports and weight loss supplements: deterenol, phenpromethamine (vonedrine), oxilofrine, octodrine, beta-methylphenylethylamine (BMPEA), 1, 3-dimethylamylamine (1, 3-DMAA), 1, 4-dimethylamylamine (1, 4-DMAA), 1, 3-dimethylbutylamine (1, 3-DMBA) and higenamine. Clin Toxicol. 2021; 59 (11): 975–81. DOI: 10.1080/15563650.2021.1894333

29. Cohen PA, Avula B, Katragunta K, Khan I. Recalls, availability, and content of dietary supplements following FDA warning letters. JAMA. 2022; 328 (4): 393–5. DOI: 10.1001/ jama.2022.9734

30. Cohen PA, Avula B, Khan I. The unapproved drug centrophenoxine (meclofenoxate) in cognitive enhancement dietary supplements. Clin Toxicol. 2022; 60 (10): 1156–8. DOI: 10.1080/15563650.2022.2109485

31. Tran BN, Okoniewski R, Spink BC, LeMaster DM, Aldous KM, Spink DC. Androgenic steroids in over-the-counter dietary supplements: analysis for association with adverse health effects. Steroids. 2023; 193: 109–199. DOI: 10.1016/j.steroids.2023.109199

32. Li L, Liang X, Xu T, Xu F, Dong W. Rapid Detection of Six Glucocorticoids Added Illegally to Dietary Supplements by Combining TLC with Spot-Concentrated Raman Scattering. Molecules. 2018; 23 (7): 1504. DOI: 10.3390/molecules23071504

33. Duiven E, van Loon LJC, Spruijt L, Koert W, de Hon OM. Undeclared Doping Substances are Highly Prevalent in Commercial Sports Nutrition Supplements. J. Sports Sci Med. 2021; 20 (2): 328–338. DOI: 10.52082/jssm.2021.328

34. Alaedini S, Amirahmadi M, Kobarfard F, Rastegar H, Nasirahmadi S, Shoeibi S. Survey of protein-based sport supplements for illegally added anabolic steroids methyltestosterone and 4-androstenedione by UPLC–MS/MS. Steroids. 2021; 165: 108758. DOI: 10.1016/j.steroids.2020.108758

35. Lee JH, Han JH, Min AY, Kim H, Shin D. Screening for twenty-eight target anabolic-androgenic steroids in protein supplements using QuEChERS extraction followed by liquid chromatography-tandem mass spectrometry. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2020; 37 (9): 1425–1436. DOI: 10.1080/19440049.2020.1773543

36. Micalizzi G, Huszti K, Pálinkás Z, Mandolfino F, Martos É, Dugo P, Mondello L, Utczás M. Reliable identification and quantification of anabolic androgenic steroids in dietary supplements by using gas chromatography coupled to triple quadrupole mass spectrometry. Drug Test Anal. 2021; 13 (1): 128–139. DOI: 10.1002/dta.2929

37. Fabresse N, Gheddar L, Kintz P, Knapp A, Larabi IA, Alvarez JC. Analysis of pharmaceutical products and dietary supplements seized from the black market among bodybuilders. Forensic Sci Int. 2021; 322: 110771. DOI: 10.1016/j.forsciint.2021.110771

38. Cheng Q., Shou L., Chen C. Application of ultra-high-performance liquid chromatography coupled with LTQ-Orbitrap mass spectrometry for identification, confirmation and quantitation of illegal adulterated weight-loss drugs in plant dietary supplements. J Chromatogr B Analyt Technol Biomed Life Sci. 2017; (1064): 92–99.

39. Walpurgis K, Thomas A, Geyer H, Mareck U, Thevis M. Dietary Supplement and Food Contaminations and Their Implications for Doping Controls. Foods. 2020; 9 (8): 1012. DOI: 10.3390/foods9081012

40. Avula B, Bae JY, Chittiboyina AG, Wang YH, Wang M, Khan IA. Liquid chromatography-quadrupole time of flight mass spectrometric method for targeted analysis of 111 nitrogen-based compounds in weight loss and ergogenic supplements. J Pharm Biomed Anal. 2019; 174: 305–323. DOI: 10.1016/j.jpba.2019.05.066.

41. Shin D, Kang HS, Kim H, Moon G. Multi-Class Determination of 64 Illicit Compounds in Dietary Supplements Using Liquid Chromatography-Tandem Mass Spectrometry. Molecules. 2020; 25 (19): 4399. DOI: 10.3390/molecules25194399

42. Rangelov Kozhuharov V, Ivanov K, Ivanova S. Higenamine in Plants as a Source of Unintentional Doping. Plants (Basel). 2022; 11 (3): 354. DOI: 10.3390/plants11030354

43. Ahmad R, Ahmad N, AlHudaithi N, AlHebshi A, Bukhari A. Extraction and UHPLC-DAD detection of undeclared substances in market-available dietary supplements and slimming products in Eastern region, Saudi Arabia: An application of principal component analysis. Biomed Chromatogr. 2020; 34 (1): e4698. DOI: 10.1002/bmc.4698

44. Zhang Y, Wu X, Wang W, Huo J, Luo J, Xu Y, Lu J. Simultaneous detection of 93 anabolic androgenic steroids in dietary supplements using gas chromatography tandem mass spectrometry. J. Pharm Biomed Anal. 2022; 211: 114619. DOI: 10.1016/j. jpba.2022.114619

45. Daher J, Mallick M, El Khoury D. Prevalence of Dietary Supplement Use among Athletes Worldwide: A Scoping Review. Nutrients. 2022; 14 (19): 4109. DOI: 10.3390/nu14194109

46. Knapik JJ, Steelman RA, Hoedebecke SS, Austin KG, Farina EK, Lieberman HR. Prevalence of Dietary Supplement Use by Athletes: Systematic Review and Meta-Analysis. Sports Med. 2016; 46(1): 103–123. DOI: 10.1007/s40279–015–0387–7

47. Garthe I, Maughan RJ. Athletes and Supplements: Prevalence and Perspectives. Int J Sport Nutr Exerc Metab. 2018; 28 (2): 126–138. DOI: 10.1123/ijsnem.2017–0429

48. Dwyer JT, Coates PM, Smith MJ. Dietary Supplements: Regulatory Challenges and Research Resources. Nutrients. 2018; 10 (1): 41. DOI: 10.3390/nu10010041

49. Tiller NB, Sullivan JP, Ekkekakis P. Baseless Claims and Pseudoscience in Health and Wellness: A Call to Action for the Sports, Exercise, and Nutrition-Science Community. Sports Med. 2023; 53 (1): 1–5. DOI: 10.1007/s40279–022–01702–2

50. Maggini V, Crescioli G, Ippoliti I, Gallo E, Menniti-Ippolito F, Chiaravalloti A, Mascherini V, Da Cas R, Potenza S, Gritti G, Galiulo MT, Sottosanti L, Vannacci A, Lombardi N, Firenzuoli F. Safety Profile of Vitamin D in Italy: An Analysis of Spontaneous Reports of Adverse Reactions Related to Drugs and Food Supplements. J. Clin. Med. 2023; 12 (14): 4726. DOI: 10.3390/jcm12144726

51. Zittermann A, Trummer C, Theiler-Schwetz V, Pilz S. Long-term supplementation with 3200 to 4000 IU of vitamin D daily and adverse events: a systematic review and meta-analysis of randomized controlled trials. Eur. J. Nutr. 2023; 62 (4): 1833–1844. DOI: 10.1007/s00394–023–03124-w

52. Geller AI, Shehab N, Weidle NJ, Lovegrove MC, Wolpert BJ, Timbo BB, Mozersky RP, Budnitz DS. Emergency Department Visits for Adverse Events Related to Dietary Supplements. N Engl. J. Med. 2015; 373 (16): 1531–40. DOI: 10.1056/NEJMsa1504267

53. Hurst P, Schiphof-Godart L, Kavussanu M, Barkoukis V, Petróczi A, Ring C. Are dietary supplement users more likely to dope than non-users?: A systematic review and meta-analysis. Int J. Drug Policy. 2023; 117: 104077. DOI: 10.1016/j.drugpo.2023.104077

54. Outram S, Stewart B. Doping through supplement use: a review of the available empirical data. Int J. Sport Nutr Exerc Metab. 2015; 25 (1): 54–9. DOI: 10.1123/ ijsnem.2013–0174

55. Jagim AR, Harty PS, Erickson JL, Tinsley GM, Garner D, Galpin AJ. Prevalence of adulteration in dietary supplements and recommendations for safe supplement practices in sport. Front Sports Act Living. 2023; (5): 1239121. DOI: 10.3389/fspor.2023.1239121

56. Martínez-Sanz JM, Sospedra I, Ortiz CM, Baladía E, Gil-Izquierdo A, Ortiz-Moncada R. Intended or Unintended Doping? A Review of the Presence of Doping Substances in Dietary Supplements Used in Sports. Nutrients. 2017; 9 (10): 1093. DOI: 10.3390/nu9101093

57. Mallick M, Camacho CB, Daher J, El Khoury D. Dietary Supplements: A Gateway to Doping? Nutrients. 2023; 15 (4): 881. DOI: 10.3390/nu15040881

58. Eichner AK, Coyles J, Fedoruk M, Maxey TD, Lenaghan RA, Novitzky J, Lindsey AT, Deuster PA. Essential Features of Third-Party Certification Programs for Dietary Supplements: A Consensus Statement. Curr Sports Med Rep. 2019; 18 (5): 178–182. DOI: 10.1249/ JSR.0000000000000595


Review

For citations:


Miroshnikov А.В., Rybakova P.D., Meshtel A.V. The prevalence of falsification of biologically active additives popular among athletes: a scoping review. Medical alphabet. 2023;(29):41-47. (In Russ.) https://doi.org/10.33667/2078-5631-2023-29-41-47

Views: 273


ISSN 2078-5631 (Print)
ISSN 2949-2807 (Online)