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Specificity of seizure genesis during electroconvulsive therapy and modified pentylenetetrazole kindling
https://doi.org/10.33667/2078-5631-2023-21-39-43
Abstract
Comparison of the development of chemically induced seizures in the experiment with the change in convulsive thresholds during electroconvulsive therapy (ECT) has demonstrated that repeated ‘chemical’ seizures can initiate the development of the kindling phenomenon, but regular ECT from the first to the 14th session most likely cause an increase in convulsive thresholds. However, the repeated ECT over 15 sessions is associated with a rapid decrease in the threshold current dose and probable dysregulation of endogenous anticonvulsant mechanisms, with the risk of the development of uncontrolled paroxysmal conditions and the risk of organic CNS lesions. The mechanisms of the convulsive action of ECT and pentylenetetrazolinduced kindling are fundamentally different. Differences in the pathogenesis of systemic convulsive reactions determine the divergent change in seizure thresholds during ECT and pentylenetetrazol stimulations.
About the Authors
V. L. Kozlovskii
St. Petersburg Bekhterev Psychoneurological Research Institute
Russian Federation
Russian Federation
Kozlovskii Vladimir L., DM Sci (habil.), leading researcher at Scientific and Organizational Dept.
Saint Petersburg
D. N. Kosterin
St. Petersburg Bekhterev Psychoneurological Research Institute
Russian Federation
Russian Federation
Kosterin Dmitry N., researcher at Dept for Treatment of Mental Disorders in Adolescents and Young Adults
Saint Petersburg
O. V. Lepik
St. Petersburg Bekhterev Psychoneurological Research Institute
Russian Federation
Russian Federation
Lepik Olga V., junior researcher at Dept for Treatment of Mental Disorders in Adolescents and Young Adults
Saint Petersburg
M. Yu. Popov
St. Petersburg Bekhterev Psychoneurological Research Institute
Russian Federation
Russian Federation
Popov Mikhail Yu., DM Sci (habil.), chief researcher, head of Dept for Treatment of Mental Disorders in Adolescents and Young Adults
Saint Petersburg
Scopus ID: 57201876256
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Review
For citations:
Kozlovskii V.L., Kosterin D.N., Lepik O.V., Popov M.Yu. Specificity of seizure genesis during electroconvulsive therapy and modified pentylenetetrazole kindling. Medical alphabet. 2023;(21):39-43. (In Russ.) https://doi.org/10.33667/2078-5631-2023-21-39-43
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