Problems of pathoanatomical diagnosis and morphological characteristics of COVID-19
https://doi.org/10.33667/2078-5631-2022-35-44-50
Abstract
The study of the human corpses who died from the coronavirus infection COVID-19 allows to define the exact cause of death, which helps clinicians in choosing a timely and effective treatment to reduce mortality. The study analyzed the current literature with the results of studies of cadaveric material and described our own pathological observations the macro- and microscopic picture that was encountered during autopsies. The description of cases of autopsies of patients who died from COVID-19 is necessary, and certainly important for a comprehensive analysis of this problem and is of high clinical and epidemiological interest.
About the Authors
Yu. I. PigolkinRussian Federation
Yuri I. Pigolkin - DM Sci (habil.), professor, RAS corr. member.
Moscow
eLibrary SPIN: 1426-5903
M. A. Kislov
Russian Federation
Maksim А. Kislov - DM Sci (habil.), associate professor.
Moscow
eLibrary SPIN: 3620-8930
S. S. Dydykin
Russian Federation
Sergei S. Dydykin - DM Sci (habil.), professor.
Moscow
О. V. Drakina
Russian Federation
Olga V. Drakina - PhD Med, associate professor.
Moscow
eLibrary SPIN: 3896-5787
K. A. Zhandarov
Russian Federation
Kirill A. Zhandarov - PhD Med, associate professor.
Moscow
М. A. Ursov
Russian Federation
Мikhail А. Ursov - resident doctor.
Moscow
D. N. Shimanovskiy
Russian Federation
Denis N. Shimanovskiy - student of International school ‘Medicine of future’.
Moscow
A. A. Volkova
Russian Federation
Student of International school ‘Medicine of future’.
Moscow
A. N. Kuzin
Russian Federation
Alexander N. Kuzin - DM Sci (habil.), аssociate зrofessor of Dept of Operative Surgery and Topographic Anatomy.
Moscow
References
1. Salian VS, Wright JA, Vedell PT, Nair S, Li C, Kandimalla M, Tang X, Carmona Porquera EM, Kalari KR, Kandimalla KK. COVID-19 Transmission, Current Treatment, and Future Therapeutic Strategies. Mol Pharm. 2021 Mar 1; 18 (3): 754–771. DOI: 10.1021/acs.molpharmaceut.0c00608. Epub 2021 Jan 19. PMID: 33464914; PMCID: PMC 7839412.
2. Зайратьянц О. В., Самсонова М. В., Михалева Л. М., Черняев А. Л., Мишнев О. Д., Крупнов Н. М., Калинин Д. В. Патологическая анатомия COVID-19 (атлас). Москва, 2020. C. 116.
3. Временные методические рекомендации «Исследование умерших с подозрением на коронавирусную инфекцию». Под ред. академика РАН, проф., д-ра мед. наук Г. А. Франка и д-ра мед. наук А. В. Ковалева. Москва, 2020. С. 431.
4. Crook H, Raza S, Nowell J, Young M, Edison P. Long Covid-mechanisms, risk factors, and management. BMJ. 2021 Jul 26; 374: n1648. DOI: 10.1136/bmj.n1648. Erratum in: BMJ. 2021 Aug 3; 374: n1944. PMID: 34312178.
5. Calabrese F, Pezzuto F, Fortarezza F, Hofman P, Kern I, Panizo A, von der Thüsen J, Timofeev S, Gorkiewicz G, Lunardi F. Pulmonary pathology and COVID-19: lessons from autopsy. The experience of European Pulmonary Pathologists. Virchows Arch. 2020 Sep; 477 (3): 359–372. DOI: 10.1007/s00428–020–02886–6. Epub 2020 Jul 9. PMID: 32642842; PMCID: PMC 7343579.
6. Отчет о текущей ситуации по борьбе с коронавирусом. Коммуникационный центр Правительства Российской Федерации 30 июня 2022. https://cdn.stopcoronovirus.ru/ai/html/3/attach/2022–06–30_coronavirus_government_report.pdf
7. Hanley B, Lucas SB, Youd E, Swift B, Osborn M. Autopsy in suspected COVID-19 cases. J Clin Pathol. 2020 May; 73 (5): 239–242. DOI: 10.1136/jclinpath-2020–206522. Epub 2020 Mar 20. PMID: 32198191. [Pomara C, Li Volti G, Cappello F. COVID-19 Deaths: Are We Sure It Is Pneumonia? Please, Autopsy, Autopsy, Autopsy! Journal of Clinical Medicine. 2020; 9 (5): 1259. https://doi.org/10.3390/jcm9051259]
8. González-Gay MA, Castañeda S, Ancochea J. Biologic Therapy in COVID-19. Arch Bronconeumol. 2021 Jan; 57: 1–2. DOI: 10.1016/j.arbres.2020.06.007. Epub 2020 Jun 26. PMID: 34629622; PMCID: PMC 7318980.
9. Временные методические рекомендации «Исследование умерших с подозрением на коронавирусную инфекцию». Под ред. академика РАН, проф., д-ра мед. наук Г. А. Франка и д-ра мед. наук А. В. Ковалева. Москва, 2020. С. 431.
10. He F, Deng Y, Li W. Coronavirus Disease 2019 (COVID-19): What we know? Journal of Medical Virology. 2020; 92 (7): 719–725. https://doi.org/10.1002/jmv.25766.
11. Yang X, Yu Y, Xu J, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: A single-centred, retrospective, observational study. The Lancet Respiratory Medicine. 2020; 8 (5): 475–481.
12. WHO Director-General's opening remarks at the media briefing on COVID-19–29 June 2020 [cited 2020 Jul 1] https://www.who.int/ru/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-COVID-19–29-june-2020.
13. Crook H, Raza S, Nowell J, Young M, Edison P. Long covid-mechanisms, risk factors, and management. BMJ. 2021 Jul 26; 374: n1648. DOI: 10.1136/bmj.n1648. Erratum in: BMJ. 2021 Aug 3; 374: n1944. PMID: 34312178.
14. Khazaal S, Harb J, Rima M, Annweiler C, Wu Y, Cao Z, Abi Khattar Z, Legros C, Kovacic H, Fajloun Z, Sabatier JM. The Pathophysiology of Long COVID throughout the Renin-Angiotensin System. Molecules. 2022 May 2; 27 (9): 2903. DOI: 10.3390/molecules27092903. PMID: 35566253; PMCID: PMC 9101946.
15. Khazaal S, Harb J, Rima M, Annweiler C, Wu Y, Cao Z, Abi Khattar Z, Legros C, Kovacic H, Fajloun Z, Sabatier JM. The Pathophysiology of Long COVID throughout the Renin-Angiotensin System. Molecules. 2022 May 2; 27 (9): 2903. DOI: 10.3390/molecules27092903. PMID: 35566253; PMCID: PMC 9101946.
16. Yao XH, Li TY, He ZC, Ping YF, Liu HW, Yu SC, Mou HM, Wang LH, Zhang HR, Fu WJ, Luo T, Liu F, Chen C, Xiao HL, Guo HT, Lin S, Xiang DF, Shi Y, Li QR, Huang X, Cui Y, Li XZ, Tang W, Pan PF, Huang XQ, Ding YQ, Bian XW. A pathological report of three COVID-19 cases by minimally invasive autopsies. Zhonghua Bing Li Xue Za Zhi. 2020; 15; 49 (0): E 009 https://doi.org/10.3760/cma.j.cn112151–20200312–00193.
17. Noor AU, Maqbool F, Bhatti ZA, Khan AU. Epidemiology of COVID-19 Pandemic: Recovery and mortality ratio around the globe. Pak J Med Sci. 2020; 36 (COVID 19-S 4): COVID 19-S 79-S 84. https://doi.org/10.12669/pjms.36.COVID 19-S 4.2660
18. Ding Y, Wang H, Shen H, et al. The clinical pathology of severe acute respiratory syndrome (SARS): a report from China. J Pathol. 2003; 200 (3): 282–289. https://doi.org/10.1002/path.1440
19. Bradley B. T., Bryan A. Emerging respiratory infections: The infectious disease pathology of SARS, MERS, pandemic influenza, and Legionella. Seminars in Diagnostic Pathology. 2019 May; 36 (3): 152–159. https://doi.org/10.1053/j.semdp.2019.04.006.
20. Edler C., Schröder A. S., Aepfelbacher M., Fitzek A., Heinemann A., Heinrich F., Klein A., Langenwalder F., Lütgehetmann M., Meißner K., Püschel K., Schädler J., Steurer S., Mushumba H., Sperhake J. P. Correction to: Dying with SARS-CoV-2 infection-an autopsy study of the first consecutive 80 cases in Hamburg, Germany. International Journal of Legal Medicine. 2020; 1: 1001–1254. https://doi.org/10.1007/s00414–020–02317-w
21. Pomara C, Li Volti G, Cappello F. COVID-19 Deaths: Are We Sure It Is Pneumonia? Please, Autopsy, Autopsy, Autopsy! Journal of Clinical Medicine. 2020; 9 (5): 1259. https://doi.org/10.3390/jcm9051259.
22. Xiao F, Tang M, Zheng X, Liu Y, Li X, Shan H, Evidence for gastrointestinal infection of SARS-CoV-2. Gastroenterology. 2020 May; 158 (6): 1831–1833 https://doi.org/10.1053/j.gastro.2020.02.055. [Yagmur G, Ziyade N, Elgormus N, Das T, Sahin M. F., Yildirim M, Ozgun A., Akcay A., Karayel F, Koc S. Postmortem diagnosis of cytomegalovirus and accompanying other infection agents by real-time PCR in cases of sudden unexpected death in infancy (SUDI). Journal of Forensic and Legal Medicine. 2016 Feb; 38: 18–23. https://doi.org/10.1016/j.jflm.2015.11.008
23. Yu C, Zhou M, Liu Y, Guo T, Ou C, Yang L, Li Y, Li D, Hu X, Shuai L, Wang B, Zou Z. Characteristics of asymptomatic COVID-19 infection and progression: A multicenter, retrospective study. Virulence. 2020 Dec; 11 (1): 1006–1014.
24. Wichmann D, Sperhake JP, Lütgehetmann M, S. Steurer, C. Edler, A. Heinemann, F. Heinrich, H. Mushumba, I. Kniep, A. S. Schröder, C. Burdelski, G. de Heer, A. Nierhaus, D. Frings, S. Pfefferle, H. Becker, H. Bredereke-Wiedling, A. de Weerth, H. R. Paschen, S. Sheikhzadeh-Eggers, A. Stang, S. Schmiedel, C. Bokemeyer, M. M. Addo, M. Aepfelbacher, K. Püschel, S. Kluge. Autopsy Findings and Venous Thromboembolism in Patients With COVID-19: A Prospective Cohort Study. Annals of internal medicine. 2020; 20: 2003. https://doi.org/10.7326/M20–2003
25. Yao XH, Li TY, He ZC, Ping YF, Liu HW, Yu SC, Mou HM, Wang LH, Zhang HR, Fu WJ, Luo T, Liu F, Chen C, Xiao HL, Guo HT, Lin S, Xiang DF, Shi Y, Li QR, Huang X, Cui Y, Li XZ, Tang W, Pan PF, Huang XQ, Ding YQ, Bian XW. A pathological report of three COVID-19 cases by minimally invasive autopsies. Zhonghua Bing Li Xue Za Zhi. 2020; 49 (5): 411–417. https://doi.org/10.3760/cma.j.cn112151–20200312–00193
26. Barton L. M., Duval E. J., Stroberg E., Ghosh S., Mukhopadhyay S. COVID-19 Autopsies, Oklahoma, USA. American Journal of Clinical Pathology. 2020; 153 (6): 725–733 https://doi.org/10.1093/ajcp/aqaa062
27. Yao XH, Li TY, He ZC, Ping YF, Liu HW, Yu SC, Mou HM, Wang LH, Zhang HR, Fu WJ, Luo T, Liu F, Chen C, Xiao HL, Guo HT, Lin S, Xiang DF, Shi Y, Li QR, Huang X, Cui Y, Li XZ, Tang W, Pan PF, Huang XQ, Ding YQ, Bian XW. A pathological report of three COVID-19 cases by minimally invasive autopsies. Zhonghua Bing Li Xue Za Zhi. 2020; 15; 49 (0): E 009. https://doi.org/10.3760/cma.j.cn112151–20200312–00193
28. Yao XH, Li TY, He ZC, Ping YF, Liu HW, Yu SC, Mou HM, Wang LH, Zhang HR, Fu WJ, Luo T, Liu F, Chen C, Xiao HL, Guo HT, Lin S, Xiang DF, Shi Y, Li QR, Huang X, Cui Y, Li XZ, Tang W, Pan PF, Huang XQ, Ding YQ, Bian XW. A pathological report of three COVID-19 cases by minimally invasive autopsies. Zhonghua Bing Li Xue Za Zhi. 2020; 15; 49 (0): E 009 https://doi.org/10.3760/cma.j.cn112151–20200312–00193
Review
For citations:
Pigolkin Yu.I., Kislov M.A., Dydykin S.S., Drakina О.V., Zhandarov K.A., Ursov М.A., Shimanovskiy D.N., Volkova A.A., Kuzin A.N. Problems of pathoanatomical diagnosis and morphological characteristics of COVID-19. Medical alphabet. 2022;(35):44-50. (In Russ.) https://doi.org/10.33667/2078-5631-2022-35-44-50