Evaluation of exfoliative cytology in endometrial pathology
https://doi.org/10.33667/2078-5631-2022-19-28-32
Abstract
Objective. Determination of the significance of cytological methods in the diagnosis of non-tumor lesions and endometrial tumors.
Materials and Methods. 69 patients who underwent surgical treatment of hysterectomy or hysteroscopy with separate diagnostic scraping of the cervical mucosa and uterine cavity. The endometrial surface was scraped by Cytobrush. Part of the material was applied to a slide for conventional cytology (CC); the remaining material was placed into the vial for liquid-based cytology (LBC). The results were analyzed using SPSS Statistical Package (SPSS: An IBM Company).
Results. Histological examination of biopsy material revealed endometrial hyperplasia without atypia (20), atypical hyperplasia (2) and adenocarcinoma (11). The sensitivity of CC and LBC for hyperplasia without atypia was estimated at 100 %, the specificity at 88 % and 94 %, respectively; the positive predictive value at 77 % and 87 %, respectively, and the negative predictive value at 100 %. The sensitivity of CC and LBC for atypical hyperplasia and adenocarcinoma was estimated at 100 %, specificity at 96 %; positive predictive value at 87 % and negative predictive value at 100 %.
Conclusions. Exfoliative cytology of material from the uterine cavity can be used as an informative method for detecting endometrial cancer and hyperplasia.
About the Authors
A. E. Karpova
Russian Medical Academy of Continuous Professional Education
Russian Federation
Russian Federation
Asel E. Karpova, postgraduate student
Dept of Clinical Laboratory Diagnostics
Moscow
I. P. Shabalova
Russian Medical Academy of Continuous Professional Education
Russian Federation
Russian Federation
Irina P. Shabalova, DM Sci (habil.), professor, professor at Dept
Dept of Clinical Laboratory Diagnostics
Moscow
K. T. Kasoyan
Russian Medical Academy of Continuous Professional Education
Russian Federation
Russian Federation
Karine T. Kasoyan, PhD Med, associate professor
Dept of Clinical Laboratory Diagnostics
Moscow
L. G. Sozaeva
Russian Medical Academy of Continuous Professional Education
Russian Federation
Russian Federation
Larisa G. Sozaeva, PhD Med, associate professor
Dept of Obstetrics and Gynecology
Moscow
O. B. Shahova
City Clinical Hospital No. 13
Russian Federation
Russian Federation
Olga B. Shakhova, PhD Med, senior researcher
Dept of Acute Gynecological Diseases
Moscow
A. V. Mironov
City Clinical Hospital No. 13
Russian Federation
Russian Federation
Aleksey V. Mironov, DM Sci (habil.), gynecologist
Department of Gynecology
Moscow
R. E. Kuznezov
City Clinical Hospital n. a. S. P. Botkin
Roman E. Kuznetsov, DM Sci (habil.), head of Dept
Department of Gynecology
Moscow
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Review
For citations:
Karpova A.E., Shabalova I.P., Kasoyan K.T., Sozaeva L.G., Shahova O.B., Mironov A.V., Kuznezov R.E. Evaluation of exfoliative cytology in endometrial pathology. Medical alphabet. 2022;(19):28-32. (In Russ.) https://doi.org/10.33667/2078-5631-2022-19-28-32
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