Is there a place for chemotherapy in first line of treatment for metastatic NSCLC in era of immunotherapy?
https://doi.org/10.33667/2078-5631-2022-13-18-21
Abstract
Nowadays we can see a significant improvement and changes in the treatment of the patients with lung cancer. The current recommendations for the treatment are constantly being changed. New schemes and medicines are coming to the clinical practice. However, there are a group of patients outside of guidelines: patients with ECOG‑2 status, clinically rapidly progressing, with severe anxiety. Such patients are not including in clinical trials. Apparently, it is not quite right to transfer the current standard recommendations for the treatment to this group of patients. This review discusses various aspects related to the choice of a first line treatment in patients with metastatic non-small cell lung cancer in the situation of time absence and luck of molecular status of the patient. Is there a place for the starting with chemotherapy or immunochemotherapy, switching to targeted therapy or immunotherapy in the process of treatment.
About the Authors
D. I. Yudin
National Medical Research Centre of Oncology n. a. N. N. Blokhin
Russian Federation
Russian Federation
Yudin Denis I., PhD Med, senior researcher
Moscow
K. K. Laktionov
National Medical Research Centre of Oncology n. a. N. N. Blokhin; Russian National Research Medical University n. a. N. I. Pirogov
Russian Federation
Russian Federation
Laktionov Konstantin K., DM Sci (habil.), professor at Dept of Oncology and Radiation Therapy of Therapeutical Faculty, Russian National Research Medical University n. a. N. I. Pirogov; head of Dept of Oncological Medicinal Methods of Treatment (Chemotherapeutic) No. 17, National Medical Research Centre of Oncology n. a. N. N. Blokhin
Moscow
References
1. Shi Y., Gu F., Hou L., Hu Y. Self-reported depression among patients with non-small cell lung cancer. Thorac Cancer. 2015 May; 6 (3): 334–337. Published online 2015 Apr 24. DOI: 10.1111/1759–7714.12179.
2. Kovacevic T., Zaric B., Bokan D., Stanic J., Perin B. Influence of anxiety and depression on one-year survival in lung cancer patients. European Respiratory Journal 2016 48: PA3073; DOI: 10.1183/13993003.congress-2016.PA3073.
3. Socinski M. A., Jotte R. M., Cappuzzo F., et al. Atezolizumab for First-Line Treatment of Metastatic Nonsquamous NSCLC. N Engl J Med. 2018; 378 (24): 2288–2301. DOI: 10.1056/NEJMoa1716948.
4. Paz-Ares L., Vicente D., Tafresh A., Robinson A., Soto Parra H., Mazières J., Hermes B., Cicin I., Medgyasszay B., Rodríguez-Cid J., et al. A Randomized, Placebo-Controlled Trial of Pembrolizumab Plus Chemotherapy in Patients With Metastatic Squamous NSCLC: Protocol-Specified Final Analysis of KEYNOTE-407. JTO, V 15, Issue 10, P. 1657–1669, October, 2020. DOI: https://doi.org/10.1016/j.jtho.2020.06.015
5. Robert Jotte, Federico Cappuzzo, Ihor Vynnychenko, Daniil Stroyakovskiy, Delvys Rodríguez-Abreu, Maen Hussein, Ross Soo, Henry J. Conter, Toshiyuki Kozuki, Kuan-Chieh Huang, Vilma Graupner, Shawn W. Sun, Tien Hoang, Helen Jessop, Mark McCleland, Marcus Ballinger, Alan Sandler, Mark A. Socinski Atezolizumab in Combination With Carboplatin and Nab-Paclitaxel in Advanced Squamous NSCLC (IMpower131): Results From a Randomized Phase III Trial. JTO. V15. Issue 8. P. 1351–1360, August 01, 2020. DOI: https://doi.org/10.1016/j.jtho.2020.03.028
6. Gadgeel S., Rodríguez-Abreu D., Speranza G., Esteban E., Felip E., Dómine M., Hui R., Hochmair M.J., Clingan P., Powell S.F., Cheng S.Y., Bischoff H.G., Peled N., Grossi F., Jennens R.R., Reck M., Garon E.B., Novello S., Rubio-Viqueira B., Boyer M., Kurata T., Gray J.E., Yang J., Bas T., Pietanza M.C., Garassino M.C. Updated Analysis From KEYNOTE-189: Pembrolizumab or Placebo Plus Pemetrexed and Platinum for Previously Untreated Metastatic Nonsquamous Non-Small-Cell Lung Cancer. J Clin Oncol. 2020 May 10; 38 (14): 1505–1517. DOI: 10.1200/JCO.19.03136. Epub 2020 Mar 9. PMID: 32150489.
7. Martin Reck, Delvys Rodríguez–Abreu, Andrew G. Robinson, Rina Hui, Tibor Csőszi, Andrea Fülöp, Maya Gottfried, Nir Peled, Ali Tafreshi, Sinead Cuffe, Mary O´Brien, Suman Rao, Katsuyuki Hotta, Kristel Vandormael, Antonio Riccio, Jing Yang, M. Catherine Pietanza, and Julie R. Brahmer. Updated Analysis of KEYNOTE-024: Pembrolizumab versus Platinum-Based Chemotherapy for Advanced Non–Small-Cell Lung Cancer With PD-L1 Tumor Proportion Score of 50% or Greater. Journal of Clinical Oncology 2019 37: 7, 537–546. DOI: 10.1200/JCO.18.00149.
8. Roy S. Herbst, M.D., Ph.D., Giuseppe Giaccone, M.D., Ph.D., Filippo de Marinis, M.D., Niels Reinmuth, M.D., Alain Vergnenegre, M.D., Carlos H. Barrios, M.D., Masahiro Morise, M.D., Enriqueta Felip, M.D., Zoran Andric, M.D., Sarayut Geater, M.D., Mustafa Özgüroğlu, M.D., Wei Zou, Ph.D., et al. Atezolizumab for First-Line Treatment of PD-L1–Selected Patients with NSCLC. N Engl J Med 2020; 383: 1328–1339. DOI: 10.1056/NEJMoa1917346.
9. West H., McCleod M., Hussein M., Morabito A., Rittmeyer A., Conter H. J., Kopp H. G., Daniel D., McCune S., Mekhail T., Zer A., Reinmuth N., Sadiq A., Sandler A., Lin W., Ochi Lohmann T., Archer V., Wang L., Kowanetz M., Cappuzzo F. Atezolizumab in combination with carboplatin plus nab-paclitaxel chemotherapy compared with chemotherapy alone as first-line treatment for metastatic non-squamous non-small-cell lung cancer (IMpower130): a multicentre, randomised, open-label, phase 3 trial Lancet Oncol. 2019 Jul; 20 (7): 924–937. DOI: 10.1016/S1470–2045(19)30167-6. Epub 2019 May 20.
10. Moiseyenko V.M., Procenko S.A., Levchenko E.V. et al. High efficacy of first-line gefitinib in non-Asian patients with EGFR-mutated lung adenocarcinoma. Onkologie. 2010. Vol. 33. P. 231–238. DOI: 10.1159/000302729.
11. Поляков И. С., Имянитов Е. Н. Молекулярная патология рака легкого: клинические аспекты. Сибирский онкологический журнал. 2013; 1 (6): 48–55. УДК: 616.24–006.6:576.3.
12. Marchetti A., Felicioni L., Malatesta S. et al. Clinical features and outcome of patients with non-small-cell lung cancer harboring BRAF mutations. J. Clin. Oncol. 2011. Vol. 29. P. 3574–3579.
13. Zhao W., Choi Y.L., Song J.Y., Zhu Y., Xu Q., Zhang F., et al. ALK, ROS1 and RET rearrangements in lung squamous cell carcinoma are very rare. Lung Cancer. 2016; 94: 22–27. DOI: 10.1016/j.lungcan.2016.01.011.
14. Mamesaya N., Nakashima K., Naito T., Nakajima T., Endo M., Takahashi T. ALK-rearranged lung squamous cell carcinoma responding to alectinib: a case report and review of the literature. BMC Cancer. 2017; 17: 471. Published online 2017 Jul 6. DOI: 10.1186/s12885-017-3468-1.
15. Cheung A., Tong J., Chung L., Chau S., Ng C., Wan I., To K. et al. EGFR mutation exists in squamous cell lung carcinoma. Pathology, Volume 52, Issue 3, April 2020, Pages 323–328. https://doi.org/10.1016/j.pathol.2019.12.003
16. Lisberg A., Cummings A., Goldman J.W., et al. A Phase II Study of Pembrolizumab in EGFR-Mutant, PD-L1+, Tyrosine Kinase Inhibitor Naive Patients with Advanced NSCLC. J Thorac Oncol. 2018; 13 (8): 1138–1145. DOI: https://doi.org/10.1016/j.jtho.2018.03.035
17. Oshima Y., Tanimoto T., Yuji K., Tojo A. EGFR-TKI-Associated Interstitial Pneumonitis in Nivolumab-Treated Patients with Non-Small Cell Lung Cancer. JAMA Oncol. 2018; 4 (8): 1112–1115. Doi: 10.1001/jamaoncol.2017.4526.
18. Liang H., Liu X., Wang M. Immunotherapy combined with epidermal growth factor receptor-tyrosine kinase inhibitors in non-small-cell lung cancer treatment. Onco Targets Ther. 2018; 11: 6189–6196. https://doi.org/10.2147/OTT.S178497
19. Ahn M.J., Yang J., Yu H., et al. 136O: Osimertinib combined with durvalumab in EGFR-mutant non-small cell lung cancer: Results from the TATTON phase Ib trial. J Thorac Oncol. 2016; 11 (4, Supplement): S115. DOI: https://doi.org/10.1016/S1556-0864(16)30246-5
20. Schoenfeld A. J., Arbour K. C., Rizvi H., et al. Severe immune-related adverse events are common with sequential PD-(L)1 blockade and osimertinib. Ann Oncol. 2019; 30 (5): 839–844. DOI: https://doi.org/10.1093/annonc/mdz077
21. Spigel D., Reynolds C., Waterhouse D., Garon E.B., Chandler J., Babu S., Thurmes P., Spira A., et al. Phase 1/2 Study of the Safety and Tolerability of Nivolumab Plus Crizotinib for the First-Line Treatment of Anaplastic Lymphoma Kinase Translocation – Positive Advanced Non–Small Cell Lung Cancer (CheckMate 370). Journal of Thoracic Oncology, Volume 13, Issue 5, May 2018, Pages 595–597. https://doi.org/10.1016/j.jtho.2018.02.022
22. Felip E. de Braud F. G. Maur M. et al. Ceritinib plus nivolumab in patients with advanced ALK-rearranged non-small cell lung cancer: results of an open-label, multicenter, phase 1B study. J Thorac Oncol. 2020; 15: 392–403. DOI: https://doi.org/10.1016/j.jtho.2019.10.006
23. Mazieres J., Drilon A.E., Mhanna L., et al. Efficacy of immune-checkpoint inhibitors (ICI) in non-small cell lung cancer (NSCLC) patients harboring activating molecular alterations (ImmunoTarget). J Clin Oncol. 2018; 36 (15_suppl): 9010–9010. DOI: https://doi.org/10.1093/annonc/mdz167
24. Gainor J. F., Shaw A. T., Sequist L. V., et al. EGFR Mutations and ALK Rearrangements Are Associated with Low Response Rates to PD-1 Pathway Blockade in Non-Small Cell Lung Cancer: A Retrospective Analysis. Clin Cancer Res. 2016; 22 (18): 4585–4593. DOI: 10.1158/1078–0432.CCR-15–3101.
25. Lee C.K., Man J., Lord S., et al. Checkpoint Inhibitors in Metastatic EGFR-Mutated Non-Small Cell Lung Cancer-A Meta-Analysis. J Thorac Oncol. 2017; 12 (2): 403–407. DOI: https://doi.org/10.1016/j.jtho.2016.10.007.
26. Dudnik E., Peled N., Nechushtan H., et al. BRAF Mutant Lung Cancer: Programmed Death Ligand 1 Expression, Tumor Mutational Burden, Microsatellite Instability Status, and Response to Immune Check-Point Inhibitors. J Thorac Oncol. 2018; 13 (8): 1128–1137. DOI: https://doi.org/10.1016/j.jtho.2018.04.024
27. Planchard D., Smit E.F., Groen H.J.M., et al. Dabrafenib plus trametinib in patients with previously untreated BRAF(V600E)-mutant metastatic non-small-cell lung cancer: an open-label, phase 2 trial. Lancet Oncol 2017; 18: 1307–16. https://doi.org/10.1016/S1470-2045(17)30679-4
28. Reck M., Rodriguez-Abreu D., Robinson A.G., et al. Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung Cancer. N Engl J Med. 2016; 375 (19): 1823–1833. DOI: 10.1056/NEJMoa1606774.
29. Gridelli C., Ardizzoni A., Le Chevalier T. et al. Treatment of advanced nonsmall-cell lung cancer patients with ECOG performance status 2: results of an European Experts Panel. Ann Oncol 2004; 15: 419–426. DOI: 10.1093/annonc/mdh087.
30. Quoix E., Zalcman G., Oster J.P. et al. Carboplatin and weekly paclitaxel doublet chemotherapy compared with monotherapy in elderly patients with advanced non-small-cell lung cancer: iFCT-0501 randomised, phase 3 trial. Lancet 2011; 378: 1079–1088. DOI: 10.1016/S0140–6736(11)60780-0.
31. Zukin M., Barrios C. H., Pereira J. R. et al. Randomized phase III trial of single-agent pemetrexed versus carboplatin and pemetrexed in patients with advanced non-small-cell lung cancer and Eastern Cooperative Oncology Group performance status of 2. J Clin Oncol 2013; 31: 2849–2853. DOI: 10.1200/JCO.2012.48.1911.
32. Yang J., Cheng Y., Murakami H., Enatsu S., Puri T., Orlando M. et al. A Randomized Phase 2 Study of Gefitinib With or Without Pemetrexed as First-line Treatment in Nonsquamous NSCLC with EGFR Mutation: Final Overall Survival and Biomarker Analysis. Journal of Thoracic Oncology Vol. 15 No. 1: 91–100. DOI: https://doi.org/10.1016/j.jtho.2019.09.008
33. Guo L., Song P., Xue X., Guo C., Han L., Fang Q., Ying J., Gao S., Li W. Variation of Programmed Death Ligand 1 Expression After Platinum-based Neoadjuvant Chemotherapy in Lung Cancer. J Immunother. 2019 Jul-Aug; 42 (6): 215–220. Published online 2019 May 28. DOI: 10.1097/CJI.0000000000000275.
34. Junghoon Shin, Jin-Haeng Chung, Se Hyun Kim, Kyu Sang Lee, Koung Jin Suh, Ji Yun Lee, Ji-Won Kim, Jeong-Ok Lee, Jin-Won Kim, Yu-Jung Kim, Keun-Wook Lee, Jee Hyun Kim, Soo-Mee Bang, Jong-Seok Lee. Effect of Platinum-Based Chemotherapy on PD-L1 Expression on Tumor Cells in Non-small Cell Lung Cancer. Cancer Res Treat. 2019 Jul; 51 (3): 1086–1097. Published online 2018 Nov 5. DOI: 10.4143/crt.2018.537.
Review
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Yudin D.I., Laktionov K.K. Is there a place for chemotherapy in first line of treatment for metastatic NSCLC in era of immunotherapy? Medical alphabet. 2022;(13):18-21. (In Russ.) https://doi.org/10.33667/2078-5631-2022-13-18-21
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