Biomarkers of non-specific inflammation and atherosclerosis of carotid arteries in obstructive sleep apnea syndrome
https://doi.org/10.33667/2078-5631-2022-6-47-52
Abstract
Purpose of study. Identification of significant laboratory markers for the development of atherosclerosis (AS) of the carotid arteries (CA) in patients with obstructive sleep apnea syndrome (OSAS).
Materials and methods. 152 male patients were examined, 84 of whom, according to polysomnography (PSG), were diagnosed with OSAS. Diagnosis of AS CA was performed by triplex scanning. The complex of laboratory studies included the assessment of lipid metabolism, the concentration of highly sensitive C-reactive protein (hsCRP), interleukin‑1β (IL‑1β), interleukin‑6 (IL‑6) and interleukin‑10 (IL‑10) in blood serum.
Results. In patients with OSAS, a statistically significant increase in the complex of proatherogenic factors was found: hsCRP, pro-inflammatory cytokines, ratio of apoproteins and atherogenic coefficient compared with patients without OSAS despite the absence of differences in the severity of atherosclerotic lesions of the carotid arteries in these groups
Conclusion. The development of OSAS is associated with severe lipid metabolism disorders and activation of nonspecific inflammation, which determines an increased risk of atherosclerosis in this group of patients.
About the Authors
E. L. Polonskiy
All-Russian Centre for Emergency and Radiation Medicine n.a. A.M. Nikiforov
Russian Federation
Russian Federation
Polonsky Evgeniy L., neurologist of Dept of Clinical Neurology, Dept of Clinical Neurology and Sleep Medicine
Saint Petersburg
N. N. Zybina
All-Russian Centre for Emergency and Radiation Medicine n.a. A.M. Nikiforov
Russian Federation
Russian Federation
Zybina Natalia N., Dr Bio Sci, professor, head of Dept of Clinical Laboratory Diagnostics
Saint Petersburg
O. V. Tikhomirova
All-Russian Centre for Emergency and Radiation Medicine n.a. A.M. Nikiforov
Russian Federation
Russian Federation
Tikhomirova Olga V., DM Sci (habil.), associate professor, head of Dept of Clinical Neurology and Sleep Medicine
Saint Petersburg
I. P. Lomova
All-Russian Centre for Emergency and Radiation Medicine n.a. A.M. Nikiforov
Russian Federation
Russian Federation
Lomova Irina P., PhD Med, senior research of Cerebrovascular Disease Laboratory
Saint Petersburg
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Review
For citations:
Polonskiy E.L., Zybina N.N., Tikhomirova O.V., Lomova I.P. Biomarkers of non-specific inflammation and atherosclerosis of carotid arteries in obstructive sleep apnea syndrome. Medical alphabet. 2022;1(6):47-52. (In Russ.) https://doi.org/10.33667/2078-5631-2022-6-47-52
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