Clinical case of cryptogenic sepsis disguised as lymphoproliferative disease

Abstract

The article presents a clinical case of sepsis occurring under the “mask” of a lymphoproliferative disease.

The purpose of the study is to substantiate the need to analyze the entire set of laboratory and clinical data for the interpretation of the results of automated analysis of biological fluids.

Materials and methods. The study was conducted on the basis of the Clinical Regional Hospital No. 2 in Krasnodar (Russia). In dynamics, the ascitic fluid and blood samples of patient P. with suspected lymphoproliferative disease were analyzed on the Sysmex XN analyzer. The results of automated analysis of abdominal effusion were compared with the results of cytological studies, as well as other laboratory and clinical data. The informative value of leukocyte indicators of inflammation (neutrophil reactivity – Neut-RI, granularity of neutrophils – Neut-GI) obtained in the ‘CBC+Diff’ mode of the Sysmex XN analyzer for the diagnosis of sepsis has been established. According to the data obtained, the predictive value of the parameter of automated analysis of biological fluids HF-BF (high fluorescent mononuclear cells) in terms of differential diagnosis of benign/malignant nature of the effusion is probabilistic.

Conclusion. To verify the diagnosis, it is necessary to take into account the full range of indicators of automated analysis of biological fluids, comparing them with clinical data, as well as the results of hematological and biochemical tests.