Cerebral stroke in patients with malignant neoplasms (literature review)

Abstract

The article reflects the significant domestic and foreign literature data result on the development of cerebral stroke against the background of malignant neoplasm analysis and the identification of specific risk factors for brain acute vascular lesions in patients with cancer.

Aim. Literature data analysis on cerebral stroke and specific risk factors for its development in patients with malignant neoplasms.

Materials and methods. Domestic and foreign literature sources on the influence of oncopathology on the cerebral stroke occurrence subject were studied.

Results. The presence of a malignant neoplasm seems to be an independent risk factor for death in patients with cerebral infarction, and its risk is the same in men and women. The main link in acute ischemic brain injury in patients with malignant neoplasms is the tissue factor expression that triggers a coagulation cascade with an increase in the level of D-dimer and other fibrin degradation products. Stroke risk is highest in the first 3 months after the detection of the tumor and significantly decreases by the year.

Conclusions. Scientific research of the oncopathology on the cerebral stroke development influence mainly concern the hemostasis study without assessing its platelet component and the oncopathology type in this category of patients, but do not sufficiently reflect the structure of acute cerebrovascular accidents. Literature analysis showed the absence of studies on the relationship between the strokes’ frequency and histological and immunohistochemical data.