Difficulties of diagnosis of Langerhans cell histiocytosis

Abstract

The disease is Langerhans cell histiocytosis from the group characterized by proliferation of macrophage phagocytic system cells in the skin, bone, bone marrow, liver, spleen, lungs, lymph nodes. In this connection, multiple lesions of various organs and systems, with the manifestations of intoxication syndrome are possible. Diverse symptoms make it significantly difficult to diagnose the disease. This demonstrates the analysis of two case histories of patients who are seen in the hematology department of Rostov state medical university clinic. Histological and immunohistochemical studies take the leading role in the diagnosis of diseases. These examples from polymorphic picture of the disease will enable clinicians to improve the diagnosis of histiocytosis of Langerhans cells in the early stages.