Visual hallucinations in Gentington's disease: ophthalmic validation of ‘North-East Visual Hallucinations Interview
https://doi.org/10.33667/2078-5631-2021-14-26-31
Abstract
Huntington's disease (HD) is a steadily progressive neurodegenerative disease caused by a mutation in the huntingtin gene, with progressive motor, cognitive and mental impairments.
The aim of the study is to determine the validity of the North‑East Visual Hallucinations Interview (NEVHI) in a Russian sample of patients.
Materials and methods. 78 subjects were examined: 26 patients at the manifest stage of HD, 21 pre‑manifest carriers of the HD gene and 31 volunteers of the control group.
Results. The low incidence of visual hallucinations according to the NEVHI does not allow us to conclude about their specificity for HD. Failure to achieve the level of statistical significance in this case suggests a high risk of type II error associated with the low occurrence of the symptom and the relatively small group size.
Conclusion. The study showed that the NEVHI questionnaire can serve as an adequate method for the diagnosis of visual hallucinations in HD.
About the Authors
S. N. Svetozarsky
Volga District Medical Centre
Russian Federation
Russian Federation
Svetozarsky Sergei N., PhD Med, ophthalmologist of Ophthalmological Dept.
Nizhni Novgorod
S. V. Kopishinskaya
Kirov State Medical University; Samara State Medical University
Russian Federation
Russian Federation
Kopishinskaya Svetlana V., PhD Med, associate prof. at Dept of Neurology and Neurosurgery
Kirov; Samara
M. A. Korotysh
Genom Co.
Russian Federation
Russian Federation
Korotysh Maria A., neurologist, neuropsychologist
Samara
I. A. Velichko
Kuban State Medical University
Russian Federation
Russian Federation
Velichko Ivan A., assistant at Dept of Nervous Diseases and Neurosurgery, Neurologist
Krasnodar
D. A. Smirnova
Samara State Medical University
Russian Federation
Russian Federation
Smirnova Daria A., PhD Med, psychiatrist
Samara
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Review
For citations:
Svetozarsky S.N., Kopishinskaya S.V., Korotysh M.A., Velichko I.A., Smirnova D.A. Visual hallucinations in Gentington's disease: ophthalmic validation of ‘North-East Visual Hallucinations Interview. Medical alphabet. 2021;(14):26-31. (In Russ.) https://doi.org/10.33667/2078-5631-2021-14-26-31
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