Influence of cranio-cerebral hypothermia on oxygen consumption, basic exchange and indicators of central hemodynamics in patients in acute period of ischemic stroke

The object of this study was to identify the specific features of the influence of craniocerebral hypothermia (CCH) on brain temperature, basal temperature, overall energy expenditure and central hemodynamics in healthy and in patients in the acute period of ischemic stroke (IS). The study included 10 healthy volunteers and 54 patients were examined in the acute period of ischemic stroke. The temperature of the brain in healthy and patients with IS was recorded by a non-invasive method using a microwave radiometer. In the healthy group, the cardiac output (litre per minute) was additionally recorded by ultrasound. The indices were fixed before the CCH, at the end of the CCH session and 1 hour after CCH in healthy and after 24 hours in patients. In all groups of patients with IS, a dynamic of changes in oxygen consumption (VOJ, energy consumption of rest (EE), respiratory coefficient (RQ) and cardiac output (CO), developing during and after CCH was analised. The work revealed that CCH provides an effective lowering of the temperature of the brain, which is the basis for reducing the overall EE and VO₂ in patients with IS, emphasizing the need for craniocerebral cooling in the acute period of IS.

ischemic stroke, therapeutic hypothermia, temperature of the brain, oxygen consumption, energy consumption of rest, cardiac output, respiratory coefficient

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