Search for new plant substances as candidates for development of skin antiseptics

Abstract

The objective of the study was search of novel extracts derived from some plants growing on the territory of the Russian Federation for application in production of novel antiseptics. Materials and methods. We worked on 24 ready-to-use work solutions of plant-derived extracts. The study was conducted on test surfaces made from smooth materials using test strains of Е. coli (1,257) and Sabin (LSc-2ab), sterile drinking water being used as control. Destruction of at least 99.9 % of the test microorganisms in the given exposure time was considered the efficacy criterion of surface decontamination. Results. A high bactericidal effect was observed in two specimens, namely, in hydroglyceric substrata (3 %) derived from abies and fir. Further studies of virucidal activity of these plants also showed their high efficacy. Conclusion. Search of novel biological substances for developing modern antiseptics is indisputably significant for nonspecific prevention of infectious diseases.