Gene polymorphism of methylentetrahydrofolate reductase C 677T in ischemic stroke at young age
https://doi.org/10.33667/2078-5631-2020-11-46-47
Abstract
Number of young people with ischemic stroke increases at the present. One of independent risk factors of stroke is hyperhomocysteinemia, wich can be caused by genetic disorders. Objective: to analyze frequency of gene polymorphism of methylentetrahydrofolate reductase C 677T and level of homocysteine among patients with stroke and people without one. Materials and methods. Data of 141 young patients with ischemic stroke, including 30 people with atherothrombotic stroke, 35 with cardioembolic, 36 with lacunar and 40 ones with cryptogenic stroke were analyzed. The control group included 40 young patients without stroke. Results. The frequency of polymorphism MTHFR C 677T (OR = 6,7; 95 % CI: 1,20–37,45: р = 0,027), allel T (OR = 2,29; 95 % CI: 1,10–4,74; р = 0,028) and the level of homocysteine are higher among stroke patients.
About the Authors
O. V. Tsyganenko
Sverdlovsk Regional Clinical Hospital No. 1
Russian Federation
Yekaterinburg
Russian Federation
Yekaterinburg
L. I. Volkova
Ural State Medical University
Russian Federation
Yekaterinburg
Russian Federation
Yekaterinburg
A. M. Alasheev
Sverdlovsk Regional Clinical Hospital No. 1
Russian Federation
Yekaterinburg
Russian Federation
Yekaterinburg
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Review
For citations:
Tsyganenko O.V., Volkova L.I., Alasheev A.M. Gene polymorphism of methylentetrahydrofolate reductase C 677T in ischemic stroke at young age. Medical alphabet. 2020;1(11):46-47. (In Russ.) https://doi.org/10.33667/2078-5631-2020-11-46-47
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