Case of successful completion of pregnancy in patient with recurrent miscarriage with concomitant thrombophilia in anamnesis
https://doi.org/10.33667/2078-5631-2019-4-33(408)-54-56
Abstract
A clinical case of successful management of a patient with recurrent miscarriage on the background of antiphospholipid syndrome, Asherman syndrome, high‑risk hereditary thrombophilia combined with hyperhomocysteinemia. The rationale for a personalized selection of pathogenetic therapy, starting with the stage of pregravid preparation and ending with the postpartum period are described in detail.
About the Authors
A. G. Yashchuk
Bashkirian State Medical University
Russian Federation
Ufa
Russian Federation
Ufa
I. B. Fatkullina
Bashkirian State Medical University
Russian Federation
Ufa
Russian Federation
Ufa
A. V. Maslennikov
Bashkirian State Medical University
Russian Federation
Ufa
Russian Federation
Ufa
E. A. Berg
Bashkirian State Medical University
Russian Federation
Ufa
Russian Federation
Ufa
Z. Sh. Mazhidova
Bashkirian State Medical University
Russian Federation
Ufa
Russian Federation
Ufa
L. K. Valieva
Maternity Hospital No. 3, Ufa
Russian Federation
Russian Federation
A. V. Kostromin
Bashkirian State Medical University
Russian Federation
Ufa
Russian Federation
Ufa
References
1. Макацария АД, Бреннер Б, Бицадзе ВО, Акиньшина СВ. Системный венозный и артериальный тромбоэмболизм в акушерско-гинекологической практике. М.: МИА; 2017.
2. Chaturvedi S, McCrae KR. Diagnosis and management of the antiphospholipid syndrome. Blood Rev. 2017; 31 (6): 406–17.
3. Подзолкова НМ, Колода ЮА, Коренная ВВ, Даньшина ВА, Кайибханова КМ. Наследственные и приобретенные тромбофилии: влияние на функциональное состояние эндометрия и яичников. Проблемы репродукции. 2015; 21; 1: 26–9.
4. Карп Г. Привычное невынашивание беременности: причины, версии и контраверсии / под ред. Говарда Дж. А. Карпа; пер. с англ. под ред. Радзинского ВЕ. М.: ГЭОТАР-Медиа; 2017.
5. Попов АА, Мананникова ТН, Алиева АС, Федоров АА, Беспалова АГ. Внутриматочные синехии: век спустя. РМЖ. 2017; 25; 12: 895–9.
6. De Jong PG, Quenby S, Bloemenkamp KW, Braams-Lisman BA, de Bruin JP, Coomarasamy A, et al. ALIFE 2 study: low-molecular-weight heparin for women with recurrent miscarriage and inherited thrombophilia — study protocol for a randomized controlled trial. Trials. 2015; 16: 208.
7. Bala MM, Paszek E, Lesniak W, Wloch-Kopec D, Jasinska K, Undas A. Antiplatelet and anticoagulant agents for primary prevention of thrombosis in individuals with antiphospholipid antibodies. Cochrane Database Syst Rev. 2018; 7; CD 012534.
8. Merviel P, Cabry R, Lourdel E, Lanta S, Amant C, Copin H, et al. Comparison of two preventive treatments for patients with recurrent miscarriages carrying a C 677T methylenetetrahydrofolate reductase mutation: 5-year experience. J Int Med Res. 2017; 45 (6): 1720–30.
9. Ye SL, Gu XK, Tao LY, Cong JM, Wang YQ. Efficacy of Different Treatment Regimens for Antiphospholipid Syndrome-related Recurrent Spontaneous Abortion. Chin Med J (Engl). 2017; 130 (12): 1395–99.
10. Mekinian A, Vicaut E, Cohen J, Bornes M, Kayem G, Fain O. Hydroxychloroquine to obtain pregnancy without adverse obstetrical events in primary antiphospholipid syndrome: French phase II multicenter randomized trial, HYDROSAPL. Gynecol Obstet Fertil Senol. 2018; 46 (7–8): 598–604.
Review
For citations:
Yashchuk A.G., Fatkullina I.B., Maslennikov A.V., Berg E.A., Mazhidova Z.Sh., Valieva L.K., Kostromin A.V. Case of successful completion of pregnancy in patient with recurrent miscarriage with concomitant thrombophilia in anamnesis. Medical alphabet. 2019;4(33):54-56. (In Russ.) https://doi.org/10.33667/2078-5631-2019-4-33(408)-54-56
Views:
3565
Email this article 