Informativeness of cytokine profile in predicting complications in patients with myocardial infarction on background of chronic obstructive pulmonary disease
https://doi.org/10.33667/2078-5631-2019-3-22(397)-33-36
Abstract
Objective. To determine the information content of the cytokine profile (IL-1β, IL-2 and IL-6) in predicting complications in patients with myocardial infarction (MI) against the background of chronic obstructive pulmonary disease (COPD).
Materials and methods. In 85 people were examined: 28 patients with myocardial infarction, 37 patients with comorbid pathology (MI + COPD) and 20 somatically healthy volunteers as a control group. Determination of IL-1β, IL-2 and IL-6 levels was basing on enzyme immunoassay.
Results. When assessing the cytokine profile in patients with MI and MI against the background of COPD, the most pronounced differences between groups of patients were observed in the levels of IL-6. Analyzing the association of the level of IL-6 with the presence of early complications of MI, it was found that the level of IL-6 in patients with complicated MI was significantly higher than in patients with uncomplicated course. The highest level of IL-6 was recorded in the subgroup of patients with complicated myocardial infarction during COPD. Studying the levels of IL-6 depending on the type of complications of myocardial infarction showed that the highest values of IL-6 were recorded in the group of comorbid patients with cardiogenic shock and pulmonary edema.
Conclusion. When determining the cytokine status in patients with myocardial infarction on the background of COPD, the level of IL-6 should be considered as the main indicator. This cytokine can be considered a marker of left ventricular that developed in the acute period in patients with myocardial infarction on the background of COPD.
About the Authors
A. V. Naumov
Astrakhan State Medical University
Russian Federation
Russian Federation
Astrakhan
L. V. Saroyants
Leprosy Research Institute
Russian Federation
Russian Federation
Astrakhan
T. V. Prokofyeva
Astrakhan State Medical University
Russian Federation
Russian Federation
Astrakhan
O. S. Polunina
Astrakhan State Medical University
Russian Federation
Russian Federation
Astrakhan
E. A. Polunina
Astrakhan State Medical University
Russian Federation
Russian Federation
Astrakhan
References
1. Аляви А. Л., Низомов А. А., Касимова Г. М. Клинико-диагностическое значение активации цитокинов и возможности коррекции нарушений у больных острым коронарным синдромом с подъемом сегмента ST. // Тезисы Рос. нац. конг. кардиологов. — 2012. — № 0024. — С. 43–44.
2. Атякшин Д. А., Цветикова Л. Н., Лобеева Н. В., А. В. Будневский, Е. С. Овсянников. Показатели иммунного статуса при хронической обструктивной болезни легких // Успехи современного естествознания. — 2015. — № 9. — С. 195–197. www.natural-sciences.ru/ru/article/view?id=35558 (дата обращения: 17.10.2018).
3. Виткина Т. И., Денисенко Ю. К., Сидлецкая К. А. Изменение экспрессии рецептора к IL-6 на поверхности иммунокомпетентных клеток при прогрессировании хронической обструктивной болезни легких // Медицинская иммунология. — 2017. — Т. 19. — № 2. — С. 191–196. DOI: 10.15789/1563–0625–2017–2–191–196.
4. Межирова Н. М., Данилова В. В., Овчаренко С. С. Патофизиологические и диагностические аспекты синдрома системного воспалительного ответа. // Медицина неотложных состояний. — 2011. — 1 (2). — С. 32–33.
5. Поликутина О. М., Слепынина Ю. С., Баздырев Е. Д., Каретникова В. Н., Барбараш О. Л. Исходы инфаркта миокарда с подъемом сегмента ST у пациентов с хронической обструктивной болезнью легких в Кемеровской области. // Рос. кард. жур. — 2014. — № 7 (111). — С. 91–97.
6. Провоторов В. М., Будневский А. В., Семенкова Г. Г., Шишкина Е. С. Провоспалительные цитокины при сочетании ишемической болезни сердца и хронической обструктивной болезни легких. // Клин. мед. — 2015. — № 93 (2). — С. 5–9.
7. Шаленкова М. А., Михайлова З. Д., Манюкова Э. Т., Басалгина Т. А., Шишкина А. П. Уровни содержания интерлейкинов и мелатонина у больных острым коронарным синдромом. // Медицинская иммунология. — 2014. — Т. 16. — № 5. — С. 473–480. DOI: 10.15789/1563–0625–2017–2–191–196 (in Russ.).
8. Kunadian V., Chan D., Ali H., Wilkinson N., Howe N., McColl E., Thornton J., von Wilamowitz-Moellendorff A., Holstein E. M., Burns G., Fisher A., Stocken D., De Soyza A. Antiplatelet therapy in the primary prevention of cardiovascular disease in patients with chronic obstructive pulmonary disease: protocol of a randomised controlled proof-ofconcept trial (APPLE COPD-ICON 2) // BMJ Open. — 2018. — Vol. 8. — № 5. — P. e020713. DOI: 10.1136/bmjopen-2017–020713.
9. La Torre G., Cocchiara R. A., Sordo E. L., Chiarini M., Siliquini R., Firenze A., Maurici M., Agati L., Saulle R., Mannocci A. J. Counseling intervention to improve quality of life in patients with pre-existing acute myocardial infarction (AMI) or chronic obstructive pulmonary disease (COPD): a pilot study // J Prev Med Hyg. — 2018. — Vol. 59. — № 2. — P. E 153—E 158.
10. Ritschel V., Shetelig C., Seljeflot I., et al. Evaluation of circulating levels of CCN 2/connective tissue growth factor in patients with ST-elevation myocardial infarction. // Scientific Reports volume 7, Article number: 11945 (2017).
Review
For citations:
Naumov A.V., Saroyants L.V., Prokofyeva T.V., Polunina O.S., Polunina E.A. Informativeness of cytokine profile in predicting complications in patients with myocardial infarction on background of chronic obstructive pulmonary disease. Medical alphabet. 2019;3(22):33-36. (In Russ.) https://doi.org/10.33667/2078-5631-2019-3-22(397)-33-36
Views:
341
Email this article 