The article gives a brief overview of the recommendations for the prescription of acetylsalicylic acid and clopidogrel in patients with cardiovascular pathology, focusing on the possible benefits of using double antiplatelet therapy: acetylsalicylic acid and clopidogrel, as the most considerable PY-inhibitor.

In the paper we present results of the research where influence of omega-3 polyunsaturated acid on lipid metabolism in patients with arterial hypertension and hyperlipidemia. The aim of the study was to estimate efficacy and safety of differently drug doses of the biologically active dietary supplements Doppel Herz aktiv® Omega-3 at patients with arterial hypertension f-ff and hyperlipidemia. fncrease of level of triglycerides more than 1.7 mmol/l and less than 4.0 mmol/l as criterion of a hyperlipidemia was used. Thereby 90 patients (average age 61.2 ± 8.3 years, males 26.7% and females 73.3 %) with arterial hypertension and hyperlipidemia were analyzed. All patients were on base antihypertensive therapy and have been divided into 3 groups. Doppel Herz aktiv® Omega-3 was added to the first and the second group of patients, the daily dose was 800 and 1,600 mg OD accordingly. Third group received traditional therapy of arterial hypertension. There were about 30 patients in each group. After 12 weeks of the treatment with Doppel Herz aktiv® Omega-3 a maximal decrease of the level of triglycerides was revealed in patients of the second group, effective dose was equal to 1,600 mg. At the same time the most significant effect was at patients with the level of triglycerides in the range from 2.3 mmol/l up to 4.0 mmol/l. The tolerance of Omega-3 was satisfactory, adverse event (dyspepsia) were non-serious and not required its cancellation.

Purpose. To evaluate gender-related differences in clinical presentation of myocardial infarction and the results of an assessment of the laboratory biomarkers level associated with inflammation and endothelial dysfunction, depending on sex. Materials and methods. The study involved 106 patients after myocardial infarction. In addition to the general clinical examination on day 14 and 3 months later, were detected of the following markers in the blood: superoxide dismutase, interleukin-6 and interleukin-10, endothelin-1 by immunoenzyme method, the level of circulating endotheliocytes was determined by flow cytometry, the content of a highly sensitive C-reactive protein and von Willebrand factor antigen with an immuno-turbidimetric method. Results. It was found that among women such risk factors of coronary arteries diseases as age, diabetes mellitus, obesity were more frequent. The disease most often occurred at the background of chronic kidney disease, myocardial infarction more often than in men has led to the development of severe heart failure. Conclusions. In all patients regardless of gender, dysfunction of the endothelium was revealed, but its implementation in women and men was carried out with the participation of various biomarkers.

This article deals with issues related to respiratory function assessment in patients with various cardiac disorders. It includes results of spirometry and body plethysmography tests carried out before and after various heart surgery procedures. There is an insistent need to use results of these tests when preparing patients for heart surgery in order to enable timely initiation of appropriate therapy, so that the risk of postoperative complications is minimized. Assessment of respiratory function is also commonly used during rehabilitation after heart surgery in patients with heart valve or coronary artery disease, helping improve the quality of life of this patient population.

Experimental study was performed on 66 white male rats Wistar. Experimental model of hypothyroidism by surgery thyroidectomy. The duration of the experiment 45 days. Laboratory animals were taken from the experiment on the 5th, 7th, 14th, 21st, 28th, 35th and 45th day. The control group consisted of 22 rats that surgery thyroidectomy was carried out. In the experiment complied with the international recommendations of the European Convention for the Protection of Vertebrate Animals. For histological examination took pieces of myocardium of the left and right ventricles and the interventricular septum. The pieces were fixed in 10 per cent solution of neutral formalin, preparing histological sections of the standard method. Histological sections were stained with hematoxylin and eosin, pikrofuxin by van Gieson, by toluidine blue, Mallory in the modification of Heidenhain, GOFP (Lilly), laxitives coating on fibrin, spent the SCHICK-reaction. Immunohistochemical studies were performed by peroxidase-antiperoxidase method. Used markers desmin, myogenin, actin sarcomeres. Histological examination of the myocardium revealed vascular disorders: venous plethora, aristrocracy, sludge-phenomenon, diapedetic hemorrhages. In the stroma of myocardium develops diffuse swelling with accumulation of edematous fluid in perivascular and intermuscular spaces. In the myocardium observed effacement of cross-striations, dystrophic changes in cardiomyocytes breach of contracture of myofibrils, pockets of plasmolysis and fragmentation of muscle fibers. In the cytoplasm of cardiomyocytes visible deposits of fibrin. In the stroma of the myocardium showed signs of disorganization of the basic substance of the connective tissue and accumulation of SCHICK-positive substances. Immunohistochemical study, a decrease in positive expression of desmin, myogenin and sarcomere actin with 3 points in the control group to 1 points in the experimental group.

From modern positions scientifically proved strategy of preventive maintenance of cardiovascular diseases is the risk factors concept. Use risk factor assessment methods of forecasting allows to define a level of total coronary risk, to reveal patients with high risk and to appoint necessary preventive actions. Computer programs can define occurrence of fatal, cardiovascular events and a diabetes on set of major factors of risk are developed.

This article focuses on the ethiology, pathogenesis, clinical symptoms, approaches to diagnosis and therapy of stress cardiomyopathy.

Given the growing medical and social importance of the CHF problem, as well as the emerging difficulties in its diagnosis in patients with a normal fraction of left ventricular ejection, there is a need to develop universal algorithms for verifying the diagnosis of CHF based on objective methods of evaluating the contractile function of the myocardium. In this connection, the present article analyzes the data of the latest foreign recommendations concerning the diagnosis of heart failure with preserved VF, with a detailed consideration of the informative value of echocardiographic parameters in verifying diastolic dysfunction. According to the updated international guidelines (ESC, ASE/EACVI), an algorithm based on an objective examination of heart function and structure by Dopplerography can be used to detect diastolic dysfunction. It is shown that the ratio of the maximum rates of E/A, the ratio of the maximum velocity of transmittal blood flow and the peak rate of myocardial relaxation to the phase of early filling of the ventricles (E/e ') are the informative parameters determining the degree of dystolic dysfunction.

Various forms of atrioventricular blockades, their diagnosis, clinical symptoms are described. Modern methods of conservative therapy are presented. Indications and contraindications for implantation of a pacemaker, resuscitation aids.

Sudden death is the most serious complication in sports cardiology. The article presents the evolution of views over the last 30 years rasprostranennosti and causes of SCD during sports. The frequency of registration of SCD in sport varies by age, sport, and other factors and ranges from 1: 100 000 to 1: 50 000 of the cases, more than 90 % of SCD occurs in males. The average age of the deceased athletes 23 years, 40 % of athletes die at the age of 18. Causes of death 53 % of young athletes up to 18 years is arrhythmia, when the autopsy do not reveal any changes, with age, the role of ischemic heart disease, myocarditis, arrhythmogenic right ventricular dysplasia. Hypertrophic and dilated cardio-myopathy according to the most recent years (2011-2016) is approximately 2-3 %, although the 80 s of the last century, they were recorded almost 40 % of cases. The role of prevention, methods of detection of heart disease. Emphasized the role of the use of automatic external defibrillators.