Experimental substantiation of crystalloid blood substitutes’ use in treatment and prevention of fat embolism
Abstract
The aim of the study was to assess in experiment the effect of infusion solution on fat globules in the blood of patients with severe combined trauma. Material and methods. 0.9- and 7.5 per cent NaCl solutions, Ringer s solution, Sterofundin iso, Sterofundin G5, Reamberin, Remaxol, Confumin were introduced into the blood in a ratio of 1 : 20, 1 : 10, 1 : 5, 1 : 3 and 1 : 2 with an estimate of the amount of fat globules. The results: 0.9- and 7.5 per cent NaCl solution, Ringer s solution and Confumin change the parameters of fat globlemia in proportion to the degree of dilution. Infusion preparations Sterofundin iso, Sterofundin G5, Remaxol and Reamberin have an independent emulsifying effect on fat globules. Conclusion. The obtained results open up the prospect of further clinical use of Sterofundin iso, Sterofundin G5, Remaxol and Reamberin in the treatment and prevention of fat embolism syndrome.
About the Authors
A. Yu. Yakovlev
Nizhniy Novgorod Regional Clinical Hospital n.a. N. A. Semashko
Russian Federation
Russian Federation
M. S. Belous
Nizhniy Novgorod Regional Clinical Hospital n.a. N. A. Semashko
Russian Federation
Russian Federation
A. A. Pevnev
Nizhniy Novgorod Regional Clinical Hospital n.a. N. A. Semashko
Russian Federation
Russian Federation
D. V. Ryabikov
City Clinical Hospital No. 13; Nizhniy Novgorod
Russian Federation
Russian Federation
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Review
For citations:
Yakovlev A.Yu., Belous M.S., Pevnev A.A., Ryabikov D.V. Experimental substantiation of crystalloid blood substitutes’ use in treatment and prevention of fat embolism. Medical alphabet. 2018;4(38):17-20. (In Russ.)
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