Indicators of oxidative stress, endothelial dysfunction and chaperone activity, depending on duration of coronary heart disease

Abstract

Objective. The aim of the study was to study changes in serum parameters of oxidative stress, endothelial dysfunction and chaperone activity in patients with coronary artery disease, depending on the duration of the underlying disease. Materials and methods. The study included 161 patients who are divided into groups by the duration of the disease: 1st group - patients with experience of the disease 5 years or less; 2nd group - patients with experience of IHD from 5 to 10 years; 3rd group - patients suffering from IHD more than 10 years and up to 15 years; 4th group - with duration of IHD from 15 to 20 years; 5th group - the duration of IHD from 20 to 25 years; 6th group - with a duration of IHD more than 25 years. Research results. When comparing the studied parameters from the duration of the disease course, significant differences between all groups were also established in terms of superoxide dismutase activity, chaperone activity, oxidized modified neutral proteins. There were no significant differences in homocysteine levels. The results obtained indicate the severity of free radical oxidation processes, their strengthening due to the decrease in chaperone activity, as well as the depletion of antioxidant forces. Significant correlations were established both in the entire sample of patients and in each group separately between the duration of the disease and the parameters of chaperone activity, superoxide dismutase activity, and the indicators of oxidative modification of proteins.