Idiopathic thrombocytopenic purpura in pregnancy (literature review)
Abstract
Management of pregnant women with ITP is important for hematologists and obstetrician-gynecologists. The article presents a review of the literature on diagnostic methods and strategies for treating pregnant women with immune thrombocytopenia. The reasons for limiting the use of the main pathogenetic drugs in a cohort in pregnant women are described in detail. The author described study with a novel approach to immune thrombocytopenia (ITP) in pregnancy (RhTPO).
About the Authors
A. B. Makeshova
People’s Friendship University
Russian Federation
Russian Federation
M. D. Ter-Ovanesov
People’s Friendship University
Russian Federation
Russian Federation
M. Yu. Kukosh
People’s Friendship University
Russian Federation
Russian Federation
A. N. Beyshenkulova
First Moscow State Medical University n.a. I. M. Sechenov
Russian Federation
Russian Federation
References
1. Данишян К. И., Соболева О. А., Галстян Г. М., Зверева А. В., Соркина О. М. Лапароскопическая спленэктомия при иммунной тромбоцитопенической пурпуре у беременных. // Терапевтический архив. 2016; 88 (7): с 109-113.
2. Ковалева Л. Г., Пустовая Е. И., Сафонова Т. И. Идиопатическая тромбоцитопеническая пурпура (ИТП) взрослых. Первичная иммунная тромбоцитопения (ИТП) взрослых. Болезнь Верльгофа. //М.: Нью Мун; 2014.
3. Меликян А. Л., Пустовая Е. И., Цветаева Н. В. и др. Национальные клинические рекомендации по диагностике и лечению первичной иммунной тромбоцитопении (идиопатической тромбоцитопенической пурпуры) у взрослых. // Гематология и трансфузиология. 2015. № 1: с 1501-1544.
4. Петрухин В. А., Мареева М. Ю., Ковалева Л. Г., Мравян С. Р. Тромбоцитопении у беременных // Рос. вестн. акуш. гин. 2011. Т. 11, № 2. C. 20-26.
5. Тютюнник В. Л., Кан Н.Е., Чупрынин В. Д., Михайлова О. И., Виноградова М. А. Опыт ведения беременных с рефрактерной тромбоцитопений. // Акушерство и гинекология: новости, мнения, обучение. № 2. 2017.
6. Alstead E. M., Ritchie J. K., Lennard-Jones J.E. et al. Safety of azathioprine in pregnancy in inflammatory bowel disease. // Gastroenterology. 1990. 99 (2): Р 443-446.
7. Bergmann F., Rath W. The Differential Diagnosis of Thrombocytopenia in Pregnancy: An interdisciplinary challenge. // Medicine. 2015. doi:10.3238/arztebl.0795.
8. Challa D. K., Velmurugan R., Ober R. J., Sally Ward E. FcRn: from molecular interactions to regulation of IgG pharmacokinetics and functions. // Curr Top Microbiol Immunol. 2014.
9. Chakravarty E. F., Murray E. R., Kelman A., Farmer P. Pregnancy outcomes after maternal exposure to rituximab. // Blood 2011;117: Р. 1499-506.
10. Decroocq J., Marcellin L., Le Ray C., Willems L. Rescue therapy with romiplostim for refractory primary immune thrombocytopenia during pregnancy. // Obstet Gynecol. 2014; 124 (2 Pt2 Suppl 1): P. 481-483.
11. Duglas B. Cines, Lisa D. Levine. Thrombocytopenia in pregnancy. American Society of Hematology. Blood2017. 130: P2271-2277.
12. Gernsheimer T., McCrae K. R. Immune thrombocytopenic purpura in pregnancy. // Curr. Opin. Hematol. 2007. 14 (5): P. 574-80.
13. Ghetie V., Ward E. S. Transcytosis and catabolism of antibody. // Immunol Res. 2002; 25 (2): P. 97-113.
14. Hachisuga K., Hidaka N., Fujita Y., Fukushima K., Kato K. Can we predict neonatal thrombocytopenia in offspring of women with idiopathic thrombocytopenic purpura? // Blood Res 2014. 49 (4): P. 259-264.
15. Hviid A., M0lgaard-Nielsen D. Corticosteroid use during pregnancy and risk of orofacial clefts. // CMAJ2011. 183 (7): P 796-804.
16. Imbach P., Crowther M. Thrombopoietin-receptor agonists for primary immune thrombocytopenia. // N Engl J Med. 2011. 365 (8): P. 734-741.
17. Loustau V., Debouverie O., Canoui-Poitrine F., et al. Effect of pregnancy on the course of immune thrombocytopenia: a retrospective study of 118 pregnancies in 82 women. // Br J Haematol2014. 166 (6): P. 929-935.
18. Neunert C., Lim W., Crowther M., Cohen A., Solberg L. Jr., Crowther M.A. The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia. //Blood. 2011. 117 (16): P. 4190-207.
19. Park-Wyllie L., Mazzotta P., Pastuszak A., et al. Birth defects after maternal exposure to corticosteroids: prospective cohort study and meta-analysis of epidemiological studies. 11 Teratology 2000. 62 (6): P 385-392.
20. Patil A. S., Dotters-Katz S.K., Metjian A. D., James A. H., Swamy G. K. Use of a thrombopoietin mimetic for chronic immune thrombocytopenic purpura in pregnancy. 11 Obstet Gynecol. 2013. 122 (2 Pt2): P. 483-485.
21. Pintova S., Bhardwaj A. S., Aledort L. M. IVIG - a hemolytic culprit. 11 N Engl J Med 2012; 367 (10): P. 974-976.
22. Price H. V., Salaman J. R., Laurence K. M., Langmaid H. Immunosuppressive drugs and the foetus. 11 Transplantation. 1976. 21 (4): P 294-298.
23. Provan D., Stasi R., Newland A. C., et al. International consensus report on the investigation and management of primary immune thrombocytopenia. 11 Blood. 2010.115 (2): P. 168-186.
24. Reddy D., Murphy S. J., Kane S. V., Present D. H., Kornbluth A. A. Relapses of inflammatory bowel disease during pregnancy: in-hospital management and birth outcomes. 11 Am J Gastroenterol. 2008. 103(5): P. 1203-1209.
25. Reeta Mahey, Simran Deep Kaur, Sunil Chumber, Alka Kriplani, and Neerja Bhatla. Splenectomy during pregnancy: treatment of refractory immune thrombocytopenic purpura. 11 Published online 2013. Dec 20. doi: 10.11361bcr-2013-201778.
26. Reindl W., Schmid R. M., Huber W. Cyclosporin A treatment of steroid-refractory ulcerative colitis during pregnancy: report of two cases. 11 Gut. 2007. 56 (7): P. 1019.
27. Roopenian D. C., Akilesh S. FcRn: the neonatal Fc receptor comes of age. 11 Nat Rev Immunol. 2007. 7 (9): P. 715-725.
28. Subbaiah M., Kumar S., Roy K. K., Sharma J.B., Singh N. Pregnancy outcome in patients with idiopathic thrombocytopenic purpura. Arch Gynecol Obstet 2014. 289 (2): P 269-273.
29. Sun D., Shehata N., Ye X. Y., et al. Corticosteroids compared with intravenous immunoglobulin for the treatment of immune thrombocytopenia in pregnancy. 11 Blood. 2016. 128 (10): P. 1329-1335.
30. van der Lugt N. M., van Kampen A., Walther F. J., Brand A., Lopriore E. Outcome and management in neonatal thrombocytopenia due to maternal idiopathic thrombocytopenic purpura. 11 Vox Sang 2013. 105 (3): P. 236-243.
31. Wegnelius Gisela, Bremme Katarina, Lindqvist Pelle G. Efficacy of treatment immune thrombocytopenic purpura in pregnancy with corticosteroids and intravenous immunoglobulin: a prospective follow-up of suggested practice. 11 Blood Coagulation & Fibrinolysis: March 2018.- Volume 29.- Issue 2. P. 141-147.
32. Winkelhorst D., Murphy M.F., Greinacher A., et al. Antenatal management in fetal and neonatal alloimmune thrombocytopenia: a systematic review. 11 Blood. 2017. 129 (11): P 1538-1547.
33. Yang B. B., Doshi S., Arkam K., Franklin J., Chow A. T. Development of romiplostim for treatment of primary immune thrombocytopenia from a pharmacokinetic and pharmacodynamic perspective. 11 Clin Pharmacokinet. 2016. 55 (9): P. 1045-1058.
34. Yildirim Y., Tinar S., Oner R. S., Kaya B., Toz E. Gestational diabetes mellitus in patients receiving long-term corticosteroid therapy during pregnancy. 11 J Perinat Med 2006. 34 (4): P. 280-284.
35. Zhangyuan Kong, Ping Qin, Shan Xiao. A novel recombinant human thrombopoietin therapy for the management of immune thrombocytopenia in pregnancy. 11 Blood 2017. 130: P1097-1103.
Review
For citations:
Makeshova A.B., Ter-Ovanesov M.D., Kukosh M.Yu., Beyshenkulova A.N. Idiopathic thrombocytopenic purpura in pregnancy (literature review). Medical alphabet. 2018;2(29):17-21. (In Russ.)
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