Role ofproinflammatory and regulatory cytokines in HIV-infection associated with tuberculosis
Abstract
Plasma levels of proinflammatory cytokines IL-2, IFN-y, TNF-а and regulatory cytokines IL-4, IL-6, IL-10 were evaluated in 75 patients with dual infection HIV+TB, 58 patients with HIV monoinfection and 50 patients with TB monoinfection who were previously naive for HAART. The decreased levels of Th1- and Th2-cytokines were observed in patients with dual infection HIV + TB in comparison with patients who had only HIV or TB. However the elevated expression of IL-6 (which stimulates the HIV-replication and inhibits the TNF-а fusion with macrophages) was noted in patients with HIV + TB co-infection. The decreased secretion of proinflammatory and regulatory cytokines in patients with HIV associated with TB may serve as immunological markers of progression of HIV-infection in patients with TB.
About the Authors
M. N. Nosik
Research Institute for Vaccines and Sera n.a. I. I. Mechnikov
Russian Federation
Russian Federation
O. A. Lobach
Research Institute for Vaccines and Sera n.a. I. I. Mechnikov
Russian Federation
Russian Federation
I. V. Rymanova
Tubercular Clinical Hospital No. 3 n.a. professor G. A. Zakharyin
Russian Federation
Russian Federation
S. E. Sevostyanikhin
Tubercular Clinical Hospital No. 3 n.a. professor G. A. Zakharyin
Russian Federation
Russian Federation
N. V. Adamovich
Tubercular Clinical Hospital No. 3 n.a. professor G. A. Zakharyin
Russian Federation
Russian Federation
A. L. Sobkin
Tubercular Clinical Hospital No. 3 n.a. professor G. A. Zakharyin
Russian Federation
Russian Federation
U. A. Kuimova
Central Research Institute for Epidemiology
Russian Federation
Russian Federation
V. A. Kravtchenko
Central Research Institute for Epidemiology
Russian Federation
Russian Federation
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Review
For citations:
Nosik M.N., Lobach O.A., Rymanova I.V., Sevostyanikhin S.E., Adamovich N.V., Sobkin A.L., Kuimova U.A., Kravtchenko V.A. Role ofproinflammatory and regulatory cytokines in HIV-infection associated with tuberculosis. Medical alphabet. 2017;1(6):26-30. (In Russ.)
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