Efficacy of neoadjuvant course of remote radiation therapy in stereotactic radiotherapy in complex treatment of patients with PEComa of pararectal tissue
Abstract
PEComa is a mesenchymal malignant tumor, which optimal treatment strategy remains undeveloped because of the rarity of occurrence of this tumor. The main treatment is surgery, but investigators continue to search for solutions that could enhance the effectiveness of resection and improve long-term results. This paper presents the case of the relative effectiveness of preoperative hormonal and radiation therapy patient with pelvic PEComa: fixed degree of therapeutic effect in remote tumor was higher than that in the above large meta analysis, and the follow-up to the resumption of the disease after complex treatment of a relapsing tumor is greater than in the primary tumor s surgical treatment.
About the Authors
A. V. Nazarenko
National Medical Research Centre of Oncology n.a. N. N. Blokhin
Russian Federation
Russian Federation
E. R. Musaev
National Medical Research Centre of Oncology n.a. N. N. Blokhin
Russian Federation
Russian Federation
S. V. Medvedev
Moscow Research Institute n.a. P. A. Herzen - a Branch of the National Medical Radiological Research Centre
Russian Federation
Russian Federation
D. S. Romanov
National Medical Research Centre of Oncology n.a. N. N. Blokhin
Russian Federation
Russian Federation
D. I. Sofronov
National Medical Research Centre of Oncology n.a. N. N. Blokhin
Russian Federation
Russian Federation
O. A. Zaspa
National Medical Research Centre of Oncology n.a. N. N. Blokhin
Russian Federation
Russian Federation
S. I. Tkachyov
National Medical Research Centre of Oncology n.a. N. N. Blokhin
Russian Federation
Russian Federation
S. B. Alieva
National Medical Research Centre of Oncology n.a. N. N. Blokhin
Russian Federation
Russian Federation
T. N. Borisova
National Medical Research Centre of Oncology n.a. N. N. Blokhin
Russian Federation
Russian Federation
V. V. Glebovskaya
National Medical Research Centre of Oncology n.a. N. N. Blokhin
Russian Federation
Russian Federation
V. A. Boldyreva
National Medical Research Centre of Oncology n.a. N. N. Blokhin
Russian Federation
Russian Federation
D. I. Fedoseenko
National Medical Research Centre of Oncology n.a. N. N. Blokhin
Russian Federation
Russian Federation
References
1. Fadare О., Parkash V., Yilmaz Y., et al. Perivascular epithelioid cell tumor (PEComa) of the uterine cervix associated with intraabdominal ‘PEComatosis’: A clinico-pathological study with comparative genomic hybridization analysis. World J Surg Oncol 2004;2:35. PMID: 15494070. DOI: 10.1186/1477-7819-2-35.
2. Cuevas Herreros O., Escobar Lezcano L., Rodriguez Blaco M., Artigas Raventos V. PEComa, a Rare Epithelioid Cell Tumor. Cir Esp 2015;93: e65-7. DOI: 10.1016/j. cireng.2013.07.034.
3. Folpe A. L., Mentzel T., Lehr H. A., et al. Perivascular epithelioid cell neoplasms of soft tissue and gynecologic origin: a clinico-pathologic study of 26 cases and review of the literature. Am J Surg Pathol 2005; 29: 1558-75. PMID: 16327428.
4. Hussain T., Al-Hamali S. Pathophysiology and management aspects of adrenal angiomyolipomas. Ann R CollSurg Engl2012; 94: 224-6. PMID: 22613297. DOI: 10.1308/0 03588412X13171221498541.
5. Нечушкина И. В., Карселадзе А. И. Пекомы. Обзор литературы и клиническое наблюдение. Саркомы костей, мягких тканей и опухоли кожи 2016; 2: 32-43.
6. Bleeker J. S., Quevedo J. F., Folpe A. L. ‘Malignant’ Perivascular Epithelioid Cell Neoplasm: Risk Stratification and Treatment Strategies. Sarcoma. Volume 2012, Article ID 541626. DOI: 10.1155/2012/541626.
7. Jeon I.S., Lee S.M. Multimodal treatment using surgery, radiotherapy, and chemotherapy in a patient with a perivascular epithelioid cell tumor of the uterus. Journal of Pediatric Hematology/ Oncology 2005; 27: 681-4. PMID: 16344678.
8. Jeon I. S., Yi D. Y. Acute lymphoblastic leukemia secondary to chemoradiotherapy for perivascular epithelioid cell tumor of uterus. Pediatric hematology and oncology 2009; 26: 85-8. PMID: 19322738. DOI: 10.1080/08880010902754859.
9. Osei D. A., Alvandi F., Brooks J. S., Ogilvie C. M. PEComa of the upper extremity: a unique case and description of an initial response to neoadjuvant chemotherapy. Sarcoma. Volume 2007, Article ID 53056. PMID: 18274609. DOI: 10.1155/2007/53056.
10. Ong L. Y., Hwang W.S., Wong A., et al. Perivascular epithelioid cell tumour of the vagina in an 8 year old girl. Journal of Pediatric Surgery 2007; 42 (3): 564-6. PMID: 17336201. DOI: 10.1016/j.jpedsurg.2006.10.050.
11. Weinreb I., Howarth D., Latta E., et al. Perivascular epithelioid cell neoplasms (PEComas): four malignant cases expanding the histopathologi-calspectrum and a description of a unique finding. Virchows Arch 2007; 450 (4): 463-70. PMID: 17377813. DOI: 10.1007/s00428-007-0378-7.
12. Yamashita K., Fletcher C. D. PEComa presenting in bone: clinicopathologic analysis of 6 cases and literature review. American Journal of Surgical Pathology 2010; 34 (11): 1622-9. PMID: 20975340. DOI: 10.1097/ PAS.0b013e3181f5974f.
Review
For citations:
Nazarenko A.V., Musaev E.R., Medvedev S.V., Romanov D.S., Sofronov D.I., Zaspa O.A., Tkachyov S.I., Alieva S.B., Borisova T.N., Glebovskaya V.V., Boldyreva V.A., Fedoseenko D.I. Efficacy of neoadjuvant course of remote radiation therapy in stereotactic radiotherapy in complex treatment of patients with PEComa of pararectal tissue. Medical alphabet. 2018;1(15):49-52. (In Russ.)
Views:
298
Email this article 