Interrelations of albuminuria, glomerular filtration rate, serum uric acid and blood pressure levels in normotensive and hypertensive people

Abstract

Purpose. The present study explores albuminuria levels and its correlations with blood pressure (BP), uric acid level, and glomerular filtration rate (GFR) in randomized representatives of Krasnoyarsk Krai population. Methods. 66 people aged 31-69 were included in the study. 11 (16.7 %) of them were males and 55 (83.3 %) were females. All study participants completed the questionnaire and underwent anthropometry, routine blood and urine analyses. Additional laboratory analysis included blood uric acid, glucose, and creatinine (with Jaffe kinetic method) levels assessment along with im-munoturbidimetric albuminuria test. In case of the indications present, the renal ultrasound scanning was performed. The results of statistical calculations performed with IBM SPSS v.22 and StatSoft Statistica v.10 were considered significant at p ≤ 0.01. Results. 35 (53 %) of the study participants appeared hypertensive. 2 (3 %) people had diabetes mellitus, and they were hypertensive too. In 18 (27.23 %) people, the uric acid level was elevated. Albuminuria had the strong direct correlation (p ≤ 0.001) with both systolic and diastolic BP levels. The reverse correlation (p < 0.001) was present between GFR and BP levels. However, the reverse correlation between GFR and uric acid level appeared weak (p = 0.014). Conclusion. The present study elucidated the strong direct correlation between albuminuria and BP levels along with the reverse correlation between GFR and BP levels. Both correlations were applicable for either hypertensive and normotensive people. The correlation between GFR and uric acid level appeared weak.