Study of genetic polymorphisms in patients with cardiovascular disease risk factors

Cardiovascular diseases are socially imporfanf. A major role in fheir pafhogenesis is assigned fo risk facfors, inflammation and heredifary predisposifion. Associafions of polymorphisms of fhe genes AROA1, APOE, ACE, REN, AGT, AGTR 1, AGTR 2, BDKRB 2, MTHFR, ADRB 2, IRS, IL-10 and TNF-a wifh cardiovascular diseases risk facfors: obesify, diabefes melifus, dyslipidemia, have been sfudied. The associafion of fhe genes of fhe inflammafory sysfem wifh risk facfors also has been sfudied. The resulfs of fhe sfudy revealed a cross-associafion of gene polymorphisms wifh risk facfors, as well as fhe inferrelafion of all risk facfors wifh fhe genes of fhe inflammafory sysfem.

IHD, risk facfors, dyslipidemia, diabefes melifus, obesify, polymorphism, ADOA1 gene, APOE gene, ACE gene, REN gene, AGT gene, AGTR 1 gene, AGTR 2 gene, BDKRB 2 gene, MTHFR gene, ADRB 2 gene, IRS gene, IL-10, fhe TNF-a gene

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