De-escalation of systemic therapy for early and locally advanced triple negative breast cancer
https://doi.org/10.33667/2078-5631-2025-33-45-52
Abstract
Neoadjuvant chemotherapy (NACT) for early and locally advanced triple negative breast cancer (TNBC) is a mandatory component of radical treatment. Achieving complete pathomorphological regress determines prognosis of the disease, allows for organ-preserving treatment, and also reduces the risk of recurrence and improves overall survival. Recently, there has been an increase number of studies aimed at intensifying NACT, which is explained by the well-known aggressiveness of this subtype of breast cancer. However, an increase frequency and severity of adverse events, which often offset the improvement in the effect of treatment, led to the emergence of studies aimed at reducing the chemotherapeutic burden of NACT breast cancer without losing its effectiveness. The studied chemotherapy regimens may become new standards for the neoadjuvant stage of complex treatment of resectable breast cancer. This review examines the current standard of systemic treatment for early and locally advanced breast cancer, as well as possible options for de-escalation of drug therapy.
About the Authors
E. I. Ratova
National Medical Research Radiological Centre
Russian Federation
Russian Federation
Ratova Evgeniya I., postgraduate student at Chemotherapy Dept, Dept of Drug Treatment of Tumors
Web of Science ResearcherID: MDS-7101-2025
Moscow
V. V. Savchina
National Medical Research Radiological Centre
Russian Federation
Russian Federation
Savchina Victoria V., researcher at Chemotherapy Dept, Dept of Drug Treatment of Tumors
Moscow
L. V. Bolotina
National Medical Research Radiological Centre
Russian Federation
Russian Federation
Bolotina Larisa V., Dr Med Sci (habil.), head of Chemotherapy Dept, Dept of Drug Treatment of Tumors
Author ID (Scopus): 594953
Moscow
A. D. Kaprin
National Medical Research Radiological Centre; Peoples’ Friendship University of Russia named after Patrice Lumumba
Russian Federation
Russian Federation
Kaprin Andrey D., Dr Med Sci (habil.), professor, RAS academician, academician of the Russian Academy of Education, general director, director of P. A. Herzen Moscow Research Institute of Oncology – branch, head of V. P. Kharchenko Dept of Oncology and Roentgenology
Author ID (Scopus): 96775
Moscow
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For citations:
Ratova E.I., Savchina V.V., Bolotina L.V., Kaprin A.D. De-escalation of systemic therapy for early and locally advanced triple negative breast cancer. Medical alphabet. 2025;(33):45-52. (In Russ.) https://doi.org/10.33667/2078-5631-2025-33-45-52
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