Remineralizing strips: an innovative form of polymer films in dentistry
https://doi.org/10.33667/2078-5631-2025-30-16-20
Abstract
Relevance. Many risk factors for dental caries (high carbohydrate consumption, poor oral hygiene, decreased enamel resistance, impaired mineralizing properties of saliva, etc.) contribute to the demineralization of hard dental tissues, which requires the use of effective remineralizing agents.
The study assessed the clinical effectiveness of using an innovative form of remineralizing agent «WATERDENT Remineralizing Strips» with calcium hydroxyapatite, potassium nitrate, sodium fluoride, calcium glycerophosphate.
Materials and methods. Type of study: prospective, open, non-comparative. The study involved 20 pati
ents aged 18 to 22 years with compensated caries and sensitive dentin. The period of use of remineralizing strips was 4 weeks. The following clinical indicators were determined for each participant before and after using the test product: caries intensity according to DMF, hygiene index OHI-S, Müllemann index, ERT (enamel resistance test), Schiff air index, tooth sensitivity according to VAS, and laboratory indicators were also determined: calcium, magnesium and phosphorus of saliva, lactate level, pH. All participants filled out a questionnaire assessing the organoleptic properties and ease of use of the «WATERDENT Remineralizing Strips».
Results. Analysis of the obtained data demonstrated a significant mineralizing and hyposensitizing effect of the studied innovative remineralizing therapy: VAS scores decreased by 31.09%, the Schiff index by 33.57%, and the Green – Vermillion index by 50.63%. TER values improved by 17.14%.
Conclusions. The study confirmed that WATERDENT Remineralizing Strips have a significant clinical effect, increasing enamel resistance, reducing hypersensitivity, and normalizing salivary parameters. The solid form ensures ease of use and can be considered an alternative to traditional gels and rinses.
About the Authors
I. V. GavrilovRussian Federation
Gavrilov Ilia V. – PhD, Associate Professor of the Department of Biochemistry
Ekaterinburg
E. V. Brusnitsyna
Russian Federation
Brusnitsyna Elena V. – PhD, Associate Professor of the Department of Pediatric Dentistry and Ortodontics
Ekaterinburg
E. S. Ioschenko
Russian Federation
Ioschenko Evgeniy S. – PhD, Associate Professor of the Department of Pediatric Dentistry and Ortodontics
Ekaterinburg
T. V. Zakirov
Russian Federation
Zakirov Taras V. – PhD, Associate Professor of the Department of Children’s Dentistry and Ortodontics
Ekaterinburg
E. N. Svetlakova
Russian Federation
Svetlakova Elena N. – MD, PhD, Associate Professor of the Department of Therapeutic Dentistry and Propaedeutics of Dental Diseases
Ekaterinburg
D. A. Ginkel
Russian Federation
Ginkel Daria A. – Dentist, Clinic of the USMU, Postgraduate Student of the Department of Therapeutic Dentistry and Propaedeutics of Dental Diseases
Ekaterinburg
E. Z. Khelashvili
Russian Federation
Khelashvili Elizaveta Z. – Assistant Professor of the Department of Pediatric Dentistry and Orthodontics
Ekaterinburg
References
1. Ailincai D., Gavril G., Marin L. Polyvinyl alcohol boric acid – A promising tool for the development of sustained release drug delivery systems. Mater Sci Eng C Mater Biol Appl. 2020 Feb;107:110316. DOI: 10.1016/j.msec.2019.110316.
2. Rokaya D., Srimaneepong V., Sapkota J., Qin J., Siraleartmukul K., Siriwongrungson V. Polymeric materials and films in dentistry: An overview. J Adv Res. 2018 May 3;14:25–34. DOI:10.1016/j.jare.2018.05.001.
3. State Pharmacopoeia of the Russian Federation. – 15th edition. [Electronic resource].Access mode: https://pharmacopoeia.regmed.ru/pharmacopoeia/izdanie-15/1/1-4/1-4-1-lekarstvennye-formy /plyenki. (date of access: 01.09.2025).
4. Handbook of Pharmaceutical Excipients. Sixth edition. Edited by Raymond C. Rowe, Paul J. Sheskey and Marian E. Quinn. 2006. P. 129–133.
5. Sablina S.N., Elovikova T.M., Grigorjev S.S., Epishova A.A., Shimova M.E., Bushueva E.J. The modern view on the use of film forming transmucoid therapeutic systems in periodontology. Actual problems in dentistry. 2020. vol. 16, № 3, p. 11–17. DOI: 10.18481/2077-7566-20-16-3-11-17
6. Kishchenko V.M., Vernikovsky V.V., Privalov I.M., Shevchenko A.M. Films in Russian medicine and cosmetology: development, history, classifi technology. Pharmacy & Pharmacology. 2020. 8(2):124–132. DOI: 10.19163/2307-9266-2020-8-2-124-132.
7. Sampiev A.M., Nikiforova E.B., Sopovskaya A.V. Current state of research in the field of creation of dental films. International Journal of Applied and Fundamental Research. 2016. № 3-2. P. 293-297. URL: https://applied-research.ru/ru/article/view?id=8723 (date of access: 26.08.2025)
8. Zalivska A.V., Zhilyakova E.T. The analysis of dental gels bases used in the treatment of gingivitis. Research Result. Medicine and Pharmacy Series. 2016;2(1):53–58. (In Russ.) DOI: 10.18413/2313-8955-2016-2-1-53-58.
9. Sementsova Е.А., Shtanko I.N., Mandra J.V., Khonina T.G. Silicone-zinc-containing glycerohydrogel as new immunotropic drug for topical application. Ural Medical Journal. No. 9 (153) 2017. Pp. 69–71. (In Russ.) eLIBRARY ID: 30546343
10. Chen X., Zhao S., Chu S., Liu S., Yu M., Li J., Gao F., Liu Y. A novel sustained release fluoride strip based Poly (propylene carbonate) for preventing caries’ Eur J Pharm Sci. 2022. Apr 1;171:106128. DOI: 10.1016/j.ejps.2022.106128
11. Vlasova N.N., Samusenkov V.O., Danilina, A.A., Nikolashvili N.I., Grishaeva K.A. Clinical evaluation of the effectiveness and safety of using of whitening strips and whitening gel as home teeth whitening treatment. Stomatology for All / Int. Dental Review. 2022, no. 4(101):56–59. (In Russ.) doi: 10.35556/idr-2022-4(101)56–59.
12. Da Rosa G. R. V. et al. Effectiveness of whitening strips use compared with supervised dental bleaching: a systematic review and meta-analysis.Operative Dentistry.2020. Т. 45. №. 6. P. E289–E307. DOI: 10.2341/19-160-L.
13. Naidu A.S., Bennani V., Brunton J., Brunton P. Over-the-Counter Tooth Whitening Agents: A Review of Literature. Braz Dent J. 2020. Jun;31(3):221–235. DOI: 10.1590/0103-6440202003227.
14. Beyer M., Reichert J., Sigusch B.W., Watts D.C., Jandt K.D. Morphology and structure of polymer layers protecting dental enamel against erosion. Dent Mater. 2012. Oct;28(10):1089-97. DOI: 10.1016/j.dental.2012.07.003.
15. Vulakh N.A., Zvereva A.A., Pichkhidze S.Ya., Kropotina A.Yu. Use of a therapeutic prophylactic dental product based on magnesium chloride, including colloidal silver and hydroxyapatite, in the complex treatment of periodontal diseases. BMIK. 2014. No. 5. URL: https://cyberleninka.ru/article/n/primenenie-lechebnogo-profilakticheskogo-stomatologicheskogo-sredstva-na-osnove-hloristogo-magniya-vklyuchayuschego-kolloidnoe (date of access: 31.08.2025).
16. Ryumina T.E., Golovanenko A.L., Tretyakova E.V., Berezina E.S., Alekseeva I.V., Pershina R.G. Biopharmaceutical studies of medicinal gel and films for the treatment of enamel caries. Modern Problems of Science and Education. 2015. No. 4. URL: https://science-education.ru/ru/article/view?id=20690 (date of access: 31.08.2025).
17. Gracia L.H., Brown A., Rees G. D., Fowler C.E. Studies on a novel combination polymer system: in vitro erosion prevention and promotion of fluoride uptake in human enamel. Journal of Dentistry. Volume 38. Supplement 3. 2010. P. S4–S11. DOI: 10.1016/S0300-5712(11)70003-3.
Review
For citations:
Gavrilov I.V., Brusnitsyna E.V., Ioschenko E.S., Zakirov T.V., Svetlakova E.N., Ginkel D.A., Khelashvili E.Z. Remineralizing strips: an innovative form of polymer films in dentistry. Dentistry. 2025;(30):16-20. (In Russ.) https://doi.org/10.33667/2078-5631-2025-30-16-20
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