Association of Helicobacter pylori infection and skin diseases. What do we know?
https://doi.org/10.33667/2078-5631-2025-25-35-38
Abstract
Helicobacter pylori (H. pylori) infection remains one of the most extensively studied pathogens involved in the development of gastroduodenal diseases. However, recent data suggest its potential role in the pathogenesis of systemic and dermatological conditions. This literature review explores the possible association between H. pylori and various skin diseases, including rosacea, acne, atopic dermatitis, and psoriasis. According to current meta-analyses, H. pylori infection is more frequently detected in patients with rosacea and psoriasis, and the bacterium may contribute to a more severe course of these dermatoses. Findings regarding acne and atopic dermatitis are inconsistent: some studies indicate a link with infection, while others suggest a protective effect or no significant correlation. The most thoroughly studied hypothesis involves H. pylori 's role in the pathogenesis of skin disorders through immunoinflammatory mechanisms, alterations in the microbiota, and pro-inflammatory cytokine activation. Nevertheless, the clinical significance of these associations remains a subject of debate. In conclusion, the review emphasizes the need for further large-scale and controlled studies to establish causal relationships between H. pylori infection and dermatological conditions. The findings may have practical implications for managing patients with chronic skin diseases and comorbid gastrointestinal disorders.
Keywords
About the Authors
V. A. Akhmedov
Omsk state medical university
Russian Federation
Russian Federation
Akhmedov Vadim A., DM Sci (habil.), professor, head of Dept of Medical Rehabilitation of Continuing Professional Education
Omsk
G. R. Bikbavova
Omsk state medical university
Russian Federation
Russian Federation
Bikbavova Galiya R., PhD Med, associate professor at Dept of Hospital Therapy and Endocrinology
Omsk
O. V. Pravdina
Omsk state medical university
Russian Federation
Russian Federation
Pravdina Olga V., PhD Med, associate professor at Dept of Dermatovenereology and Cosmetology
Omsk
E. A. Gulida
Omsk state medical university
Russian Federation
Russian Federation
Gulida Ekaterina A., student at Faculty of General Medicine
Omsk
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Review
For citations:
Akhmedov V.A., Bikbavova G.R., Pravdina O.V., Gulida E.A. Association of Helicobacter pylori infection and skin diseases. What do we know? Medical alphabet. 2025;(25):35-38. (In Russ.) https://doi.org/10.33667/2078-5631-2025-25-35-38
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