Study of circulating regulatory T cells in solid cancers
https://doi.org/10.33667/2078-5631-2025-22-55-58
Abstract
Regulatory T cells (Tregs) play a key role in maintaining peripheral immune tolerance. Disorders in their functioning are associated with the development of autoimmune, allergic and oncological diseases.
The aim of the study was to evaluate the involvement of circulating Treg cells in the development of solid malignancies.
Materials and methods. The level of Treg cells (CD 45+CD 4+CD 25+CD 127-/low) in the peripheral blood of patients with cervical cancer (CC, n=10), prostate cancer (PC, n=23) and lung cancer (LC, n=10) was determined by flow cytofluorometry. The control group consisted of 40 healthy donors. The Mann-Whitney U-test was used to compare the indicators of the groups.
Results. The study showed an increased level of circulating Treg cells in patients with CC, PC and LC compared with the control group (p<0.05). In CC Treg cells levels were increased 1.5–fold (relative number) and 2.5-fold (absolute number); in PC, they were increased 1.8-fold (both relative and absolute), which possibly indicates the involvement of these cells in the pathogenesis of cancer regardless of gender. The most pronounced increase in Treg cells was observed in LC (2.7 and 3.2 times in percentage and absolute number, respectively), which correlates with the late stages of the disease.
Conclusion. The data obtained confirm the universal role of Treg cells in the development and progression of solid tumors, which indicates the promise of immunomodulatory approaches aimed at regulating the activity of these cells.
About the Authors
T. Yu. Mushkarina
А. Tsyb Medical Radiological Research Centre – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Mushkarina Tatyana Yu., researcher at Dept of Clinical Immunology
Obninsk
E. G. Kuzmina
А. Tsyb Medical Radiological Research Centre – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Kuzmina Evgenia G., PhD Bio Sci, senior researcher at Dept of Clinical Immunology
Obninsk
V. A. Biryukov
А. Tsyb Medical Radiological Research Centre – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Biryukov Vitaly A., PhD Med, head of Dept of Contact Radiotherapy
Obninsk
G. V. Afonin
А. Tsyb Medical Radiological Research Centre – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Afonin Grigory V., PhD Med, head of Dept of Radiation and Surgical Treatment of Thoracic Diseases
Obninsk
L. Yu. Grivtsova
А. Tsyb Medical Radiological Research Centre – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Grivtsova Lyudmila Yu., Dr Bio Sci, head of Dept of Clinical Immunology
Obninsk
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Review
For citations:
Mushkarina T.Yu., Kuzmina E.G., Biryukov V.A., Afonin G.V., Grivtsova L.Yu. Study of circulating regulatory T cells in solid cancers. Medical alphabet. 2025;(22):55-58. (In Russ.) https://doi.org/10.33667/2078-5631-2025-22-55-58
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