The role of serotonergic activity in impulsive aggression and illegal behavior
https://doi.org/10.33667/2078-5631-2025-21-55-59
Abstract
Impulsive aggression is considered an important psychopathological symptom of a number of mental disorders, including borderline and antisocial personality disorders. Serotonin plays a critical role in modulating mood, anxiety, aggression, sleep-wake cycle, motivation, pain perception and neuroendocrine function, including aggression suppression. The correlation of the severity of aggressive behavior with neuroendocrine signs of low serotonin function was revealed. Serotonergic genes play an important role in the regulation of serotonin activity. The article discusses the results of research conducted among those convicted of violent and nonviolent crimes. The association of various genes regulating serotonin activity with aggression has been studied. The characteristics of several serotonergic candidate genes for the risk of developing antisocial behavior, which is based on impulsive aggression, are given. In conclusion, the conclusion is made about the inconsistency of the results of the analyzed studies due to methodological differences, which requires further development of this problem.
About the Authors
N. V. Orlova
N. I. Pirogov Russian National Research Medical University (Pirogov University); Tyumen State University
Russian Federation
Russian Federation
Orlova Natalia V., DM Sci (habil.), professor at Dept of Faculty Therapy of Institute of Motherhood and Childhood; leading researcher at the laboratory
Moscow; Tyumen
G. N. Suvorov
Tyumen State University
Russian Federation
Russian Federation
Suvorov Georgy N., PhD Law, head of Dept of Scientific and Innovative Work, head of the laboratory
Tyumen
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Review
For citations:
Orlova N.V., Suvorov G.N. The role of serotonergic activity in impulsive aggression and illegal behavior. Medical alphabet. 2025;(21):55-59. (In Russ.) https://doi.org/10.33667/2078-5631-2025-21-55-59
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