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Undifferentiated connective tissue dysplasia and skin: what to do? Dietitian’s position
https://doi.org/10.33667/2078-5631-2025-19-60-70
Abstract
Undifferentiated connective tissue dysplasia (UCTD) is a common hidden diagnosis at a cosmetologist and dermatologist appointment, which can affect the prognosis, choice of procedure and patient management tactics. Being a genetically determined disorder of connective tissue formation and manifested by polymorphic changes in the skin, joints, blood vessels and internal organs, UCTD has no clear diagnostic criteria, which complicates timely diagnostics. A particular problem is premature aging, which in patients with UCTD is ahead of biological age by an average of 8 years, and impaired full tissue reparation against the background of UCTD. These changes are due to impaired synthesis of collagen, elastin and glycosaminoglycans. Since UCTD is a genetic pathology, it cannot be completely eliminated, but an integrated approach, including diet therapy and correction of micronutrient deficiencies, can slow down the progression of dysplastic changes and improve reparative processes after hardware-based and injectable cosmetology procedures. This review examines key nutrients that affect connective tissue metabolism, as well as current data on the effectiveness of diet therapy and dietary supplements for UCTD.
Supporting agencies: The publication was supported by the RUDN Strategic Academic Leadership Program.
About the Authors
E. A. Nikitina
ФГАОУ ВО «Российский университет дружбы народов имени Патриса Лумумбы» (РУДН) ; ГБУЗ «Научно-практический центр детской психоневрологии Департамента здравоохранения г. Москвы» ; ФГБУ «Национальный медицинский исследовательский центр терапии и профилактической медицины» Минздрава России
Russian Federation
Russian Federation
Nikitina Elena A., PhD Med, associate professor at Dept of Dietetics and Clinical Nutrition, research fellow2, expert of Methodological Accreditation and Simulation Center
S. V. Orlova
ФГАОУ ВО «Российский университет дружбы народов имени Патриса Лумумбы» (РУДН) ; ГБУЗ «Научно-практический центр детской психоневрологии Департамента здравоохранения г. Москвы»
Russian Federation
Russian Federation
Orlova Svetlana V., DM Sci (habil.), professor, head of Dept of Dietetics and Clinical Nutritiology, Chief Researcher
T. T. Batysheva
ФГАОУ ВО «Российский университет дружбы народов имени Патриса Лумумбы» (РУДН) ; ГБУЗ «Научно-практический центр детской психоневрологии Департамента здравоохранения г. Москвы»
Russian Federation
Russian Federation
Batysheva Tatyana T., DM Sci (habil.), professor, Honored Doctor of the Russian Federation, head of Dept of Neurology, Physical, Rehabilitation Medicine and Childhood Psychology, director, chief freelance pediatric neurologist of the Moscow Health Department, chief freelance pediatric specialist in medical rehabilitation of the Russian Ministry of Health
N. V. Balashova
ФГАОУ ВО «Российский университет дружбы народов имени Патриса Лумумбы» (РУДН) ; ГБУЗ МО «Московский областной научно-исследовательский клинический институт имени М.Ф. Владимирского»
Russian Federation
Russian Federation
Balashova Natalya V., PhD Bio, assistant professor at Dept of Dietetics and Clinical Nutritiology, assistant professor at Dept of Clinical Laboratory Diagnostics of the Faculty of Advanced Training of Doctors
Author ID: 832745
M. V. Alekseeva
ГБУЗ «Научно-практический центр детской психоневрологии Департамента здравоохранения г. Москвы»
Russian Federation
Russian Federation
Alekseeva Marina.V., Ph.D., Deputy Director for Organizational and Methodological Work
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Nikitina E.A., Orlova S.V., Batysheva T.T., Balashova N.V., Alekseeva M.V. Undifferentiated connective tissue dysplasia and skin: what to do? Dietitian’s position. Medical alphabet. 2025;1(19):60-71. (In Russ.) https://doi.org/10.33667/2078-5631-2025-19-60-70
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