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Aspects of the immune response in West Nile virus infection
https://doi.org/10.33667/2078-5631-2025-16-64-67
Abstract
West Nile fever (WNF) is a zoonotic infection caused by West Nile virus (WNV), which belongs to the family Flaviviridae and the genus Flavivirus. The virus is transmitted to humans through the bites of infected mosquitoes, most often from the genus Culex. The relevance of this infection remains at a high level due to its worldwide spread and damage to the central nervous system. Also, methods of specific diagnosis and treatment of this disease have not been developed. Research on the immune system can help solve these problems. The immune response to West Nile virus is a complex interaction of innate and adaptive mechanisms. While the immune system usually effectively controls infection, in some cases excessive inflammation or an insufficient immune response can lead to severe consequences, including damage to the central nervous system. Understanding these mechanisms is of key importance for the development of vaccines and therapeutic approaches to the treatment of WNF.
About the Authors
A. A. Istin
Voronezh State Medical University named after N.N. Burdenko
Russian Federation
Russian Federation
Istin Alexander A., resident at Dept of Infectious Diseases and Clinical Immunology
Voronezh
O. N. Krasnorutskaya
Voronezh State Medical University named after N.N. Burdenko
Russian Federation
Russian Federation
Krasnorutskaya Olga N., DM Sci (habil.), associate professor, head of Dept of Infectious Diseases and Clinical Immunology
Voronezh
AuthorID: 727938
A. S. Bezlepkin
Voronezh State Medical University named after N.N. Burdenko
Russian Federation
Russian Federation
Bezlepkin Anton S., resident at Dept of Infectious Diseases and Clinical Immunology
Voronezh
V. I. Shevtsova
Voronezh State Medical University named after N.N. Burdenko
Russian Federation
Russian Federation
Shevtsova Veronika I., PhD Med, associate professor at Dept of Infectious Diseases and Clinical Immunology
Voronezh
G. G. Salomakhin
Voronezh State Medical University named after N.N. Burdenko
Russian Federation
Russian Federation
Salomakhin Georgy G., PhD Med, associate professor at Dept of Infectious Diseases and Clinical Immunology
Voronezh
AuthorID: 690475
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Review
For citations:
Istin A.A., Krasnorutskaya O.N., Bezlepkin A.S., Shevtsova V.I., Salomakhin G.G. Aspects of the immune response in West Nile virus infection. Medical alphabet. 2025;(16):64-67. (In Russ.) https://doi.org/10.33667/2078-5631-2025-16-64-67
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