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Ischemic stroke in women in Dagestan: laboratory and genetic aspects
https://doi.org/10.33667/2078-5631-2025-15-21-25
Abstract
Introduction. Stroke has been the leading cause of death worldwide for decades. Despite the improvement of diagnostic methods, for 40 % of patients who have suffered an ischemic stroke, its cause cannot be established. The high incidence of stroke remains a serious problem for the healthcare system, requiring increased attention and the development of new preventive strategies.
Objective: to establish the relationship between some modifiable and non-modifiable factors and the occurrence of ischemic stroke in women in the Republic of Dagestan.
Methods. The study used a cross-sectional continuous study design. The study included 75 women in the acute period of ischemic stroke and 35 women living in Dagestan without a history of acute cerebrovascular accident. The study analyzed the results of laboratory and molecular genetic research methods.
Results. Two genes make a significant contribution to the risk of ischemic stroke in Dagestan. Hyperhomocysteinemia can be regarded as a marker of acute cerebral ischemia in women in Dagestan. A statistically significant higher level of homocysteine was found in patients with the TT variant of the MTHFR gene (p<0.05). Patients with ischemic stroke in the presence of 4G/4G polymorphism of the PAI-1 gene have a statistically significantly higher atherogenic index value compared to patients with 5G/5G polymorphism.
Conclusion. Not all studied modifiable and non-modifiable factors contribute to the development of stroke in women in Dagestan. Molecular genetic methods in modern medicine are becoming routine, and their use as non-modifiable risk factors can become an important component of personalized diagnostics.
About the Author
K. B. Manysheva
Dagestan State Medical University
Russian Federation
Russian Federation
Manysheva Ksenia B., assistant professor at Dept of Nervous Diseases, Medical Genetics and Neurosurgery
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For citations:
Manysheva K.B. Ischemic stroke in women in Dagestan: laboratory and genetic aspects. Medical alphabet. 2025;(15):21-25. (In Russ.) https://doi.org/10.33667/2078-5631-2025-15-21-25
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