The prevalence of resistance to meropenem among microorganisms detected in children's hospital patients

The aim is to assess the prevalence and significance of resistance to meropenem among conditionally pathogenic microorganisms detected in various biological materials in children's hospital patients.

Materials and methods. The results of microbiological studies of 43936 samples of biological material taken from 41287 children hospitalized in 2023 with various pathologies aged from birth to 18 years were studied.

Results. Among all samples of biomaterial, certain bacteria were detected in 16034 cases (36 %). In 5431 samples, Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, Pseudomonas aeruginosa with different sensitivity to meropenem were detected. The largest number of samples containing meropenem-resistant colonies was found among Klebsiella pneumoniae (471), and the largest number of cases of resistance was found among Acinetobacter baumannii (183 out of 433). Resistance to meropenem in Escherichia coli was detected only in isolated cases (12 samples – 1,4 %).Conclusions. 1. Among the microorganisms detected in samples of various biomaterials, 4 microorganisms (Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, Pseudomonas aeruginosa) with potential resistance to meropenem were found in 34 %, more often – Escherichia coli (in 43 %). 2. The most common colonies resistant to meropenem were identified among Klebsiella pneumoniae (in 26 %), more often in feces and rectal smears. 3. The highest proportion of meropenem-resistant colonies was found among Acinetobacter baumannii (43 %). 4. The high frequency of detection of resistant strains requires further monitoring and prescribing antibacterial therapy regimens, taking into account the results of laboratory assessment of their sensitivity.

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