Normozoospermia. Is it always the norm?
https://doi.org/10.33667/2078-5631-2024-8-53-56
Abstract
The combination of male and female infertility leads to infertility in 2/3 of cases. To date, it is considered that male infertility is clinically manifested as pathological changes in the spermogram. This article presents a clinical observation of a 40-year-old man who has not had children for 3 years, but in this case, the sperm data show normozoospermia. The results of physical examination and ultrasound of the scrotum did not reveal any pathological changes. A detailed examination of the patient revealed a DNA fragmentation of spermatozoa of more than 20%, which was difficult to correct with medication. The conclusion of the laboratory study of the ejaculate – «normozoospermia» is not always an indicator of the reproductive health of a particular patient. Infertile men with normozoospermia need an extended diagnosis, with the determination of DNA fragmentation of spermatozoa.
About the Authors
D. V. MoskvichevRussian Federation
Moskvichev Dmitry V., PhD Med, head of Urological Dep,
Moscow.
R. S. Frantsev
Russian Federation
Frantsev Roman S., PhD Med, Associate Professor at Dept of Urology, urologist,
Stavropol.
Author ID: 844410.
A. G. Strachuk
Russian Federation
Strachuk Alexander G., PhD Med, Associate Professor at Dept of General Medical Practice,
Moscow.
E. A. Korovyakova
Russian Federation
Korovyakova Elina A., PhD Med, Associate Professor at Dept of General and Clinical Pharmacology of the Medical Insitute,
Moscow.
Author ID: 351781.
Scopus Author ID: 57201327585.
A. V. Kuchuk
Russian Federation
Kuchuk Andrey V., PhD Med, Senior Lecturer at Dept of Human Anatomy of the Medical Institute,
Moscow.
E. A. Presnova
Russian Federation
Presnova Elizaveta A., 2nd year Student of the Faculty of Medicine of the Medical Institute,
Moscow.
References
1. Kulchenko N.G., Druzhinina N.K., Myandina G.I. Male infertility along with the era of coronavirus infection SARS-CoV‑2. Research and Practical Medicine Journal (Issled. prakt. med.). 2022; 9 (4): 123–133. (In Russ.). https://doi.org/10.17709/2410-1893-2022-9-4-12
2. Kulchenko N. G. Inguinal hernia repair and male health. Research and Practical Medicine Journal (Issled. prakt. med.). 2019; 6 (3): 65–73. (In Russ.). DOI: 10.17709/2409-2231-2019-6-3-6
3. Kulchenko N.G. Mast cell population in the testicle during pathospermia. Russian Medical Inquiry. 2022; 6 (4): 195–199. (In Russ.). DOI: 10.32364/2587-6821-2022-6-4-195-199
4. Kulchenko N.G., Myandina G.I., Alhedjoj Hasan. Assotiation-genetic study of polymorphism G‑105A SEPS1 gene in male infertility. Research’n Practical Medicine Journal (Issled. prakt. med.). 2018; 5 (2): 65–71. (In Russ.). DOI: 10.17709/2409-2231-2018-5–2-7
5. Pimenov E.P., Andryukhin M.I. The role of DNA fragmentation in the pathogenesis of male infertility. Bulletin «Biomedicine and sociology» 2019; 4 (1): 38–41. (In Russ.).
6. Tarasova T. V., Saushev I. V. Genetic causes of azoospermia. Vestnik Biomedicina i sociologiya. 2019; 4(2): 16–20. (In Russ.). http://dx.doi.org/10.26787/nydha‑2618–8783-2019-4-2-16-20
7. Chen Q, Zhao JY, Xue X, Zhu GX. The association between sperm DNA fragmentation and reproductive outcomes following intrauterine insemination, a meta-analysis. Reprod Toxicol. 2019; 86: 50–55. DOI: 10.1016/j.reprotox.2019.03.004
8. Ferraretti AP, Goossens V, Kupka M. et al. Assisted reproductive technology in Europe, 2009: results generated from European registers by ESHRE. Hum Reprod. 2013; 28 (9): 2318–2331. DOI: 10.1093/humrep/det278
9. Hamada A, Esteves SC, Agarwal A. Unexplained male infertility: potential causes and management. Hum Androl. 2011; 1: 2–16. DOI: 10.1097/01.XHA.0000397686.82729.09
10. Intasqui P., Agarwal A., Sharma R., Samanta L., Bertolla R.P. Towards the identification of reliable sperm biomarkers for male infertility: A sperm proteomic approach. Andrologia. 2018; 50: e12919. DOI: 10.1111/and.12919
11. Kichine E., Di Falco M., Hales B.F., Robaire B., Chan P. Analysis of the sperm head protein profiles in fertile men: Consistency across time in the levels of expression of heat shock proteins and peroxiredoxins. PLoS ONE. 2013; 8: e77471. DOI: 10.1371/journal.pone.0077471
12. Liu X., Liu G., Liu J., Zhu P., Wang J., Wang Y., Wang W., Li N., Wang X., Zhang C., et al. iTRAQ-based analysis of sperm proteome from normozoospermic men achieving the rescue-ICSI pregnancy after the IVF failure. Clin. Proteom. 2018; 15: 27. DOI: 10.1186/s12014–018–9203–3
13. Myandina GI, Hasan A, Azova MM, Tarasenko EV, Kulchenko NG. Influence of GSTP1 gene polymorhism on decreased semen quality. Russian Open Medical Journal. 2019; 8: e0411. DOI: 10.15275/rusomj.2019.0411
14. Pacey A. Is sperm DNA fragmentation a useful test that identifies a treatable cause of male infertility? Best Pract. Res Clin. Obstet. Gynaecol. 2018; 53: 11–19. DOI: 10.1016/j.bpobgyn.2018.09.003
15. Pan MM, Hockenberry MS, Kirby EW, Lipshultz LI. Male Infertility Diagnosis and Treatment in the Era of In Vitro Fertilization and Intracytoplasmic Sperm Injection. Med. Clin. North. Am. 2018; 102: 337–47. DOI: 10.1016/j.mcna.2017.10.008
16. Salas-Huetos A, Blanco J, Vidal F. Spermatozoa from normozoospermic fertile and infertile individuals convey a distinct miRNA cargo. Andrology. 2016; 4 (6): 1028–1036. DOI: 10.1111/andr.12276
17. Vinnakota C, Cree L, Peek J, Morbeck DE. Incidence of high sperm DNA fragmentation in a targeted population of subfertile men. Syst. Biol. Reprod. Med. 2019; 65 (6): 451–457. DOI: 10.1080/19396368.2019.1668077
18. Zini A, Lefebvre J, Kornitzer G. Anti-sperm antibody levels are not related to fertilization or pregnancy rates after IVF or IVF/ICSI. J. Reprod. Immunol. 2011; 88 (1): 80–84. DOI: 10.1016/j.jri.2010.09.002
Review
For citations:
Moskvichev D.V., Frantsev R.S., Strachuk A.G., Korovyakova E.A., Kuchuk A.V., Presnova E.A. Normozoospermia. Is it always the norm? Medical alphabet. 2024;(8):53-56. (In Russ.) https://doi.org/10.33667/2078-5631-2024-8-53-56