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Pathophysiology of anemic syndrome in celiac disease and its therapeutic treatment
https://doi.org/10.33667/2078-5631-2023-28-13-18
Abstract
The review presents modern ideas about the pathophysiology of the anemia syndrome associated with celiac disease. Brief information is provided about the main proteins involved in iron metabolism and their role in maintaining homeostasis. Attention is paid to the multifactorial pathogenetic mechanisms of anemia in celiac disease, the state of the duodenal mucosa and ultrastructural changes in the villi of enterocytes with signs of atrophy, which play a key role in the regulation of iron absorption, and also provides information on the mechanisms of the development of functional iron deficiency and its role in the pathogenesis of anemia of chronic diseases.
About the Authors
L. S. Oreshko
Military Medical Academy n. a. S. M. Kirov
Russian Federation
Russian Federation
Oreshko Lyudmila S., DM Sci (habil.), professor, associate professor at 2nd Dept (Therapy for Advanced Training of Physicians)
Saint Petersburg
S. S. Ledentsova
Saint Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
Ledentsova Svetlana S., dermatologist of Consultative and Diagnostic Centre
Saint Petersburg
P. V. Seliverstov
Military Medical Academy n. a. S. M. Kirov
Russian Federation
Russian Federation
Seliverstov Pavel V., PhD Med, associate professor at 2nd Dept (Therapy for Advanced Training of Physicians)
Saint Petersburg
S. P. Salikova
Military Medical Academy n. a. S. M. Kirov
Russian Federation
Russian Federation
Salikova Svetlana P., DM Sci (habil.), associate professor at 2nd Dept (Therapy for Advanced Training of Physicians)
Saint Petersburg
E. S. Ivanyuk
Military Medical Academy n. a. S. M. Kirov
Russian Federation
Russian Federation
Ivanyuk Elena S., PhD Med, gastroenterologist, associate professor at 2nd Dept (Therapy for Advanced Training of Physicians)
Saint Petersburg
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Review
For citations:
Oreshko L.S., Ledentsova S.S., Seliverstov P.V., Salikova S.P., Ivanyuk E.S. Pathophysiology of anemic syndrome in celiac disease and its therapeutic treatment. Medical alphabet. 2023;(28):13-18. (In Russ.) https://doi.org/10.33667/2078-5631-2023-28-13-18
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