Evaluation of PPARγ expression in skin of acne patients
https://doi.org/10.33667/2078-5631-2022-27-21-23
Abstract
Acne is a chronic disease of the pilosebaceous unit. Much attention is paid to the pathogenesis and optimization of acne therapy. Evidence is emerging about the role of PPARγ receptors in maintaining inflammation and increasing sebum production, as well as an indirect role in the development of pruritus, which may allow for a correlation between the severity of inflammation in acne, the prevalence of pruritus, and the influence of PPARγ receptor expression on these processes.
About the Authors
A. N. LvovRussian Federation
Lvov Andrey N., DM Sci (habil.), professor, head of Dept of Postgraduate Studies and Residency, professor at Dermatovenerology and Cosmetology Dept; senior researcher
Moscow
E. E. Sidorenko
Russian Federation
Sidorenko Elizaveta E., dermatovenereologist of Therapeutic Dept, senior assistant at Laboratory of Dept of Skin and Venereal Diseases
Rostov-on-Don
References
1. Strauss J., Krowchuk D., Leyden J., et al. Guidelines of care for acne vulgaris management. J. Am. Acad. Dermatol. 2007; 56: 651–63.
2. Kurokawa I, Danby FW, Ju Q, Wang X, Xiang LF, Xia L, Chen W, Nagy I, Picardo M, Suh DH, Ganceviciene R, Schagen S, Tsatsou F, Zouboulis CC. New developments in our understanding of acne pathogenesis and treatment. Exp Dermatol. 2009 Oct; 18 (10): 821–32. DOI: 10.1111/j.1600–0625.2009.00890.x.
3. Niemeier V, Kupfer J, Gieler U. Acne vulgaris – psychosomatic aspects. J Dtsch Dermatol Ges. 2006 Dec; 4 (12): 1027–36.
4. Zouboulis CC. Acne and sebaceous gland function. Clin Dermatol. 2004 Sep-Oct; 22 (5): 360–6. DOI: 10.1016/j.clindermatol.2004.03.004. PMID: 15556719.
5. Amr K, Abdel-Hameed M, Sayed K, Nour-Edin F, Abdel Hay R. The Pro12Ala polymorphism of the gene for peroxisome proliferator activated receptor-gamma is associated with a lower Global Acne Grading System score in patients with acne vulgaris. Clin Exp Dermatol. 2014 Aug; 39 (6): 741–5. DOI: 10.1111/ced.12394. Epub 2014 Jul 1. PMID: 24984871.
6. Saeidi S, Chamaie-Nejad F, Ebrahimi A, Najafi F, Rahimi Z, Vaisi-Raygani A, Shakiba E, Rahimi Z. PPARγ Pro12Ala and C161T polymorphisms in patients with acne vulgaris: Contribution to lipid and lipoprotein profile. Adv Med Sci. 2018 Mar; 63 (1): 147–151. DOI: 10.1016/j.advms.2017.09.003. Epub 2017 Nov 6. PMID: 29120856.
7. Ostadhadi S, Nikoui V, Haj-Mirzaian A, Kordjazy N, Dehpour AR. The role of PPAR-gamma receptor in pruritus. Eur J Pharmacol. 2015 Sep 5; 762: 322–5. DOI: 10.1016/j.ejphar.2015.06.009. Epub 2015 Jun 6. PMID: 26057695.
8. Ustinov MV. Hypothesis of the implementation of the anti-relapse effect of systemic isotretinoin on acne. Clinical Dermatology and Venereology. 2019; 18 (4): 505512. (In Russ.). https://doi.org/10.17116/klinderma201918041505
9. Potekaev N.N., Tkachenko S.B., Ashapkin V.V., Karymov O.N., Kutueva L.I. Acne of mature age: Molecular and genetic analysis. Experimental and clinical dermatocosmetology. 2011. No. 1. P. 25–32.
10. Reich A., Szepietowski J.C. Acne and itch: direct relationship or comorbidity? Expert Review of Dermatology, 2007, Vol. 2, Acne and itch, No. 6, P. 735–739.
11. Lim Y., Chan Y., Yosipovitch G., Greaves M. Pruritus is a common and significant symptom of acne//Journal of the European Academy of Dermatology and Venereology, 2008, Vol. 22, No. 11, P. 1332–1336.
12. Dalgard F., Halvorsen J.A., Kwatra S.G., Yosipovitch G. Acne severity and itch are associated: results from a Norwegian survey of 3775 adolescents. British Journal of Dermatology, 2013, Vol. 169, Acne severity and itch are associated, No. 1, P. 215–216.
13. Koo J.Y.M., Smith L.L. Psychologic Aspects of Acne//Pediatric Dermatology, 1991, Vol. 8, No. 3, P. 185–188.
Review
For citations:
Lvov A.N., Sidorenko E.E. Evaluation of PPARγ expression in skin of acne patients. Medical alphabet. 2022;1(27):21-23. (In Russ.) https://doi.org/10.33667/2078-5631-2022-27-21-23