Preview

Medical alphabet

Advanced search

The role of iron during pregnancy and lactation

https://doi.org/10.33667/2078-5631-2022-24-8-15

Abstract

Nutrition is one of the important factors for a successful pregnancy and its outcome, sufficient lactation, maintaining the health of the mother, fetus and newborn. The development of the fetus is directly dependent on the nutritional status of the mother, and if the nutrition is inadequate, the supply of the fetus will be limited, which can lead to competition between mother and child for nutrients. A diet depleted of micronutrients, primarily iron, can lead to iron deficiency in the mother and affect lactation function. Evidence suggests that unbalanced nutrition and iron deficiency in the fetus can have a negative impact on human health in the postnatal period, as well as affect the metabolic status of future generations. Iron deficiency occurs as a result of a discrepancy between the need increased during pregnancy and the intake of the mineral from food, which leads to disruption of the work of all organs and systems, and reduces physical and mental performance. If a latent iron deficiency is detected, it is necessary to balance the diet, and use IUDs or iron preparations as a nutritional correction. When iron deficiency anemia is detected, it is necessary to use iron preparations along with complex diet therapy, taking into account the effect of individual nutrients on the absorption of the microelement.

About the Authors

S. V. Orlova
Peoples Friendship University of Russia (RUDN University)
Russian Federation

Orlova Svetlana V., DM Sci (habil.), professor, head of Dept of Dietetics and Clinical Nutritiology

Moscow



E. A. Nikitina
Peoples Friendship University of Russia (RUDN University)
Russian Federation

Nikitina Elena A., PhD Med, assistant professor of Dept of Dietetics and Clinical Nutritiology

Moscow



N. V. Balashova
Peoples Friendship University of Russia (RUDN University)
Russian Federation

Balashova Natalya V., PhD Bio Sci, assistant of Dept of Dietetics and Clinical Nutritiology

Moscow



References

1. Ong TP, Moreno FS, Ross SA. Targeting the epigenome with bioactive food components for cancer prevention. J. Nutrigenet. Nutrigenomics. 2011;4(5):275–92. doi: 10.1159/000334585

2. Cetin I, Berti C, Calabrese S. Role of micronutrients in the periconceptional period. Hum Reprod Update. 2010 Jan-Feb;16(1):80–95. doi: 10.1093/humupd/dmp025

3. Fernandez-Twinn DS, Ozanne SE. Early life nutrition and metabolic programming. Ann N Y Acad Sci. 2010 Nov;1212:78–96. doi: 10.1111/j.1749–6632.2010.05798.x

4. Dominguez-Salas P, Moore SE, Baker MS, Bergen AW, Cox SE, Dyer RA, Fulford AJ, Guan Y, Laritsky E, Silver MJ, Swan GE, Zeisel SH, Innis SM, Waterland RA, Prentice AM, Hennig BJ. Maternal nutrition at conception modulates DNA methylation of human metastable epialleles. Nat. Commun. 2014 Apr 29;5:3746. doi: 10.1038/ncomms4746

5. Jackson AA, Burdge GC, Lillycrop KA. Diet, nutrition and modulation of genomic expression in fetal origins of adult disease. World Rev. Nutr. Diet. 2010;101:56–72. doi: 10.1159/000314511

6. Guidelines for the Use of Iron Supplements to Prevent and Treat Iron Deficiency Anemia. WHO.1998.

7. The global prevalence of anaemia in 2011. WHO. Geneva: World Health Organization; 2015.

8. Kumari R, Bharti RK, Singh K, Sinha A, Kumar S, Saran A, Kumar U. Prevalence of Iron Deficiency and Iron Deficiency Anaemia in Adolescent Girls in a Tertiary Care Hospital. J. Clin. Diagn. Res. 2017 Aug;11(8): BC 04–BC 06. doi: 10.7860/JCDR/2017/26163.10325

9. Chaparro C. M., Suchdev P. S. Anemia epidemiology, pathophysiology, and etiology in low- and middle-income countries. Ann N Y Acad. Sci. 2019;1450(1):15–31. DOI: 10.1111/nyas.14092

10. World Health Organization. Анемия // Информационные бюллетени. Geneva (Switzerland): WHO, – 2019.

11. UNICEF, United Nations University, WHO. Iron deficiency anemia: assessment, prevention and control. A guide for programme managers.Geneva: World Health Organization; 2001 (WHO/NHD/ 01.3). – 114 p. Available at: http://www.who.int/nutrition/publications/micronutrients/anaemia_iron_deficiency/WHO_NHD_01.3/en.

12. Logutova L. S. Anemia in pregnant women: issues of etiology, diagnosis and treatment/Russkiy meditsinskiy zhurnla. Mat’ i ditya [Russian Medical Journal. Mother and Child]. 2016;5:290–3 (in Russ.). https://www.rmj.ru/articles/akusherstvo/Anemiya_u_beremennyh_voprosy_etiologii_diagnostikiilecheniya/#ixzz7anFmTwjq.

13. Demikhov V. G., Morshchakova E. F., Rumyantsev A. G. Pathogenesis and treatment of anemia in pregnancy. Moscow, 2015. 224 p.

14. Guideline: Daily iron supplementation in adult women and adolescent girls. Geneva: World Health Organization; 2016.

15. Aggett PJ. Iron. In: Erdman JW, Macdonald IA, Zeisel SH, eds. Present Knowledge in Nutrition. 10th ed. Washington, DC: Wiley-Blackwell; 2012:506–20.

16. Murray-Kolbe LE, Beard J. Iron. In: Coates PM, Betz JM, Blackman MR, et al., eds. Encyclopedia of Dietary Supplements. 2nd ed. London and New York: Informa Healthcare; 2010:432–8.

17. Iron. Micronutrient Information Center of Linus Pauling Institute. https://lpi.oregonstate.edu/mic/minerals/iron

18. Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Molybdenum, Nickel, Silicon, Vanadium and Zinc. Food and Nutrition Board. Washington, DC: National Academy Press; 2001.

19. Bianchi VE. Role of nutrition on anemia in elderly. Clin. Nutr. ESPEN. 2016 Feb;11: e1–e11. doi: 10.1016/j.clnesp.2015.09.003

20. Nelson M, White J, Rhodes C. Haemoglobin, ferritin, and iron intakes in British children aged 12–14 years: a preliminary investigation. Br J Nutr. 1993 Jul;70(1):147–55. Doi: 10.1079/bjn19930112

21. Vici G, Belli L, Biondi M, Polzonetti V. Gluten free diet and nutrient deficiencies: A review. Clin. Nutr. 2016 Dec;35(6):1236–1241. doi: 10.1016/j.clnu.2016.05.002

22. Koletzko B, Bauer CP, Bung P, Cremer M, Flothkötter M, Hellmers C, Kersting M, Krawinkel M, Przyrembel H, Rasenack R, Schäfer T, Vetter K, Wahn U, Weissenborn A, Wöckel A. German national consensus recommendations on nutrition and lifestyle in pregnancy by the ‘Healthy Start – Young Family Network’. Ann Nutr. Metab. 2013;63(4):311–22. doi: 10.1159/000358398

23. Hercberg S, Preziosi P, Galan P. Iron deficiency in Europe. Public. Health Nutr. 2001 Apr;4(2B):537–45. doi: 10.1079/phn2001139

24. Vohr BR, Poggi Davis E, Wanke CA, Krebs NF. Neurodevelopment: The Impact of Nutrition and Inflammation During Preconception and Pregnancy in Low-Resource Settings. Pediatrics. 2017 Apr;139(Suppl 1): S 38–S 49. doi: 10.1542/peds.2016–2828F

25. Flynn AC, Begum S, White SL, Dalrymple K, Gill C, Alwan NA, Kiely M, Latunde-Dada G, Bell R, Briley AL, Nelson SM, Oteng-Ntim E, Sandall J, Sanders TA, Whitworth M, Murray DM, Kenny LC, Poston L. SCOPE and UBPEAT Consortiums. Relationships between Maternal Obesity and Maternal and Neonatal Iron Status. Nutrients. 2018 Jul 30;10(8):1000. doi: 10.3390/nu10081000

26. Bodnar LM, Parrott MS. Intervention strategies: to improve outcome in obese pregnancies: micronutrients and dietary supplementations. In: Gillman MW, Poston L, editors. Maternal obesity. Cambridge: Cambridge University Press; 2012:199–207.

27. Lefebvre P, Letois F, Sultan A, Nocca D, Mura T, Galtier F. Nutrient deficiencies in patients with obesity considering bariatric surgery: a cross-sectional study. Surg. Obes. Relat. Dis. 2014 May-Jun;10(3):540–6. doi: 10.1016/j.soard.2013.10.003.

28. Nicoletti CF, Lima TP, Donadelli SP, Salgado W Jr, Marchini JS, Nonino CB. New look at nutritional care for obese patient candidates for bariatric surgery. Surg Obes Relat Dis. 2013 Jul-Aug;9(4):520–5. doi: 10.1016/j.soard.2011.08.010

29. Obstetrics: Textbook / G. M. Savelyeva, V. I. Kulakov, A44 A. N. Strizhakov and others; Ed. G. M. Savelyeva. – M.: Medicine, 2000. – 816 p.

30. Anemia in pregnancy. A manual for doctors and interns, Edition 2, revised and supplemented. Yaroslavl. M. V. Khitrov, M. B. Okhapkin, I. N. Ilyashenko, 2002.

31. Ivanyan A. N., Nikiforovich I. I., Litvinov A. V. A modern view of anemia in pregnant women // Russian Bulletin of the Obstetrician-Gynecologist. 1, 2009, p. 17–20.

32. Methodical recommendations MR 2.3.1.0253–21 “Norms of physiological requirements in energy and nutrients of various groups of the population of the Russian Federation”, approved by the Head of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing Chief State Sanitary Physician of the Russian Federation 22.07.2021 (in Russ.). https://www.rospotrebnadzor.ru/documents/details.php?ELEMENT_ID=18979

33. Hurrell R, Egli I. Iron bioavailability and dietary reference values. Am. J. Clin. Nutr. 2010 May;91(5):1461S‑1467S. doi: 10.3945/ajcn.2010.28674F.

34. Galan P, Vergnaud AC, Tzoulaki I, Buyck JF, Blacher J, Czernichow S, Hercberg S. Low total and nonheme iron intakes are associated with a greater risk of hypertension. J. Nutr. 2010 Jan;140(1):75–80. doi: 10.3945/jn.109.114082

35. Monsen ER. Iron nutrition and absorption: dietary factors which impact iron bioavailability. J. Am. Diet. Assoc. 1988 Jul;88(7):786–90. PMID: 3290310.

36. DeLoughery TG. Iron deficiency anemia. Med. Clin. North. Am. 2017 Mar;101(2):319–32. doi: 10.1016/j.mcna.2016.09.004

37. Pavord S, Daru J, Prasannan N, Robinson S, Stanworth S, Girling J; BSH Committee. UK guidelines on the management of iron deficiency in pregnancy. Br. J. Haematol. 2020 Mar;188(6):819–830. doi: 10.1111/bjh.16221

38. Peña-Rosas JP, De-Regil LM, Gomez Malave H, Flores-Urrutia MC, Dowswell T. Intermittent oral iron supplementation during pregnancy. Cochrane Database Syst. Rev. 2015 Oct 19;2015(10): CD 009997. doi: 10.1002/14651858.CD009997.pub2

39. Murat S, Ali U, Serdal K, Süleyman D, İlknur P, Mehmet S, Bahattin A, Tunahan U. Assessment of subjective sleep quality in iron deficiency anaemia. Afr. Health Sci. 2015 Jun;15(2):621–7. doi: 10.4314/ahs.v15i2.40

40. Azami M, Badfar G, Khalighi Z, Qasemi P, Shohani M, Soleymani A, Abbasalizadeh S. The association between anemia and postpartum depression: A systematic review and meta-analysis. Caspian. J. Intern. Med. 2019 Spring;10(2):115–124. doi: 10.22088/cjim.10.2.115

41. Lowensohn RI, Stadler DD, Naze C. Current Concepts of Maternal Nutrition. Obstet. Gynecol. Surv. 2016 Aug;71(7):413–26. doi: 10.1097/OGX.0000000000000329

42. Shevchenko Yu.L., Novik A. A., Melnichenko V. Ya. Anemia: a guide to diagnosis and treatment. – M.: RANS, 2012. – 350 p.

43. Mihaila C, Schramm J, Strathmann FG, Lee DL, Gelein RM, Luebke AE, Mayer-Pröschel M. Identifying a window of vulnerability during fetal development in a maternal iron restriction model. PLoS One. 2011 Mar 15;6(3): e17483. doi: 10.1371/journal.pone.0017483

44. Georgieff MK. Iron deficiency in pregnancy. Am. J. Obstet. Gynecol. 2020 Oct;223(4):516–524. doi: 10.1016/j.ajog.2020.03.006

45. Butte NF, Fox MK, Briefel RR, Siega-Riz AM, Dwyer JT, Deming DM, Reidy KC. Nutrient intakes of US infants, toddlers, and preschoolers meet or exceed dietary reference intakes. J. Am. Diet. Assoc. 2010 Dec;110(12 Suppl): S 27–37. doi: 10.1016/j.jada.2010.09.004

46. Blanck HM, Cogswell ME, Gillespie C, Reyes M. Iron supplement use and iron status among US adults: results from the third National Health and Nutrition Examination Survey. Am. J. Clin. Nutr. 2005 Nov;82(5):1024–31. doi: 10.1093/ajcn/82.5.1024

47. Black MM, Quigg AM, Hurley KM, Pepper MR. Iron deficiency and iron-deficiency anemia in the first two years of life: strategies to prevent loss of developmental potential. Nutr. Rev. 2011 Nov;69 Suppl 1: S 64–70. doi: 10.1111/j.1753–4887.2011.00435.x

48. Mills RJ, Davies MW. Enteral iron supplementation in preterm and low birth weight infants. Cochrane Database Syst. Rev. 2012 Mar 14;(3): CD 005095. doi: 10.1002/14651858.CD005095.pub2

49. Suchdev PS, Jefferds MED, Ota E, da Silva Lopes K, De-Regil LM. Home fortification of foods with multiple micronutrient powders for health and nutrition in children under two years of age. Cochrane Database Syst. Rev. 2020 Feb 28;2(2): CD 008959. doi: 10.1002/14651858.CD 008959.pub3

50. Greminger AR, Lee DL, Shrager P, Mayer-Pröschel M. Gestational iron deficiency differentially alters the structure and function of white and gray matter brain regions of developing rats. J. Nutr. 2014 Jul;144(7):1058–66. doi: 10.3945/jn.113.187732

51. Rees WD, Hay SM, Hayes HE, Stevens VJ, Gambling L, McArdle HJ. Iron deficiency during pregnancy and lactation modifies the fatty acid composition of the brain of neonatal rats. J. Dev. Orig. Health Dis. 2020 Jun;11(3):264–272. doi: 10.1017/S2040174419000552

52. Ajmera AV, Shastri GS, Gajera MJ, Judge TA. Suboptimal response to ferrous sulfate in iron-deficient patients taking omeprazole. Am. J. Ther. 2012 May;19(3):185–9. Doi: 10.1097/MJT.0b013e3181f9f6d2

53. Yusrawati Y, Defrin D, Karmia HR. Neonatal Growth, Neurotrophine, Zinc, and Ferritin Concentration in Normal and Iron Deficience Pregnancy: An Observational Analitic Study. Open Access Maced J. Med. Sci. 2019 Apr 14;7(7):1114–1118. doi: 10.3889/oamjms.2019.202

54. Harvey L, Boksa P. Additive effects of maternal iron deficiency and prenatal immune activation on adult behaviors in rat offspring. Brain Behav Immun. 2014 Aug;40:27–37. doi: 10.1016/j.bbi.2014.06.005

55. Tamura T, Goldenberg RL, Hou J, Johnston KE, Cliver SP, Ramey SL, Nelson KG. Cord serum ferritin concentrations and mental and psychomotor development of children at five years of age. J. Pediatr. 2002 Feb;140(2):165–70. doi: 10.1067/mpd.2002.120688

56. Geltman PL, Meyers AF, Mehta SD, Brugnara C, Villon I, Wu YA, Bauchner H. Daily multivitamins with iron to prevent anemia in high-risk infants: a randomized clinical trial. Pediatrics. 2004 Jul;114(1):86–93. doi: 10.1542/peds.114.1.86

57. Cornock R, Gambling L, Langley-Evans SC, McArdle HJ, McMullen S. The effect of feeding a low iron diet prior to and during gestation on fetal and maternal iron homeostasis in two strains of rat. Reprod. Biol. Endocrinol. 2013 May 1;11:32. doi: 10.1186/1477–7827–11–32

58. McKeating DR, Fisher JJ, Perkins AV. Elemental Metabolomics and Pregnancy Outcomes. Nutrients. 2019 Jan 2;11(1):73. doi: 10.3390/nu11010073

59. Brock JH, Mulero V. Cellular and molecular aspects of iron and immune function. Proc Nutr Soc. 2000 Nov;59(4):537–40. doi: 10.1017/s002966510000077x

60. WHO. Nutritional Anaemias: Tools for Effective Prevention and Control; World Health Organization: Geneva, Switzerland, 2017; Available online: https://apps.who.int/iris/bitstream/handle/10665/259425/9789241513067-eng.pdf (accessed on 29 March 2020).

61. Viteri FE. Iron endowment at birth: maternal iron status and other influences. Nutr. Rev. 2011 Nov;69 Suppl 1: S 3–16. doi: 10.1111/j.1753–4887.2011.00449.x

62. Zhukovskaya, E.; Karelin, A.; Rumyantsev, A. Neurocognitive Dysfunctions in Iron Deficiency Patients. In Iron Deficiency Anemia; Rodrigo, L., Ed.; IntechOpen: London, UK, 2019; pp. 83–113.

63. Guo Y, Zhang N, Zhang D, Ren Q, Ganz T, Liu S, Nemeth E. Iron homeostasis in pregnancy and spontaneous abortion. Am. J. Hematol. 2019 Feb;94(2):184–188. doi: 10.1002/ajh.25341

64. Parisi F, di Bartolo I, Savasi VM, Cetin I. Micronutrient supplementation in pregnancy: Who, what and how much? Obstet. Med. 2019 Mar;12(1):5–13. doi: 10.1177/1753495X18769213

65. Encyclopedia of Iron (CD edition). Vifor International, 2008.

66. Nagornaya N. V., Dubovaya A. V., Alferov V. V., Meshcheryakova A. V., Kharlap I. V. The value of minerals in the physiology and pathology of the child // Health of the child. –2008. – No. 15. – P. 12–26.

67. Rasulov S. K. Microelementosis in children questions of rational nutrition // Problems of biology and medicine. – 2005. – No. 3. – P. 137–139.

68. Orlova S. V., Nikitina E. A., Prokopenko E. V., Vodolazkaya A. N. Influence of vitamin and mineral complexes on the composition of breast milk. Medical. Alphabet. 2021;1(11):40–49 (in Russ.) https://doi.org/10.33667/2078–5631–2021–11–40–49

69. Citrakesumasari, Vonny kalsum, Chaidir Masyhuri Majiding, Tenri Andi Ayu Rahman, Yessy Kurniati, Mineral Concentrations in Breast Milk across Infant Birth Weight. Pak. J. Nutr., 2020.19: 32–37. DOI: 10.3923/pjn.2020.32.37

70. Davenport C, Yan J, Taesuwan S, Shields K, West AA, Jiang X, Perry CA, Malysheva OV, Stabler SP, Allen RH, Caudill MA. Choline intakes exceeding recommendations during human lactation improve breast milk choline content by increasing PEMT pathway metabolites. J. Nutr. Biochem. 2015 Sep;26(9):903–11. doi: 10.1016/j.jnutbio.2015.03.004

71. Buss IH, McGill F, Darlow BA, Winterbourn CC. Vitamin C is reduced in human milk after storage. Acta Pediatr. 2001 Jul;90(7):813–5.

72. Hermoso M, Vollhardt C, Bergmann K, Koletzko B. Critical micronutrients in pregnancy, lactation, and infancy: considerations on vitamin D, folic acid, and iron, and priorities for future research. Ann. Nutr. Metab. 2011;59(1):5–9. doi: 10.1159/000332062

73. Berenhauser AC, Pinheiro do Prado AC, da Silva RC, Gioielli LA, Block JM. Fatty acid composition in preterm and term breast milk. Int J. Food. Sci. Nutr. 2012 May;63(3):318–25. doi: 10.3109/09637486.2011.627843

74. El-Farrash RA, Ismail EA, Nada AS. Cord blood iron profile and breast milk micronutrients in maternal iron deficiency anemia. Pediatr. Blood Cancer. 2012 Feb;58(2):233–8. Doi: 10.1002/pbc.23184

75. Dylewski ML, Picciano MF. Milk selenium content is enhanced by modest selenium supplementation in extended lactation. J. Trace. Elem. Exp. Med. 2002;15:191–199. DOI: 10.1002/jtra.10016

76. Bo LG, Lin Q, Ping O, Xian XR. Analysis on dietary survey and influencing factors of wet nurses during puerperal period. Chinese J. Matern. Child. Health. 2015;30(18):3029–31.

77. McCauley ME, van den Broek N, Dou L, Othman M. Vitamin A supplementation during pregnancy for maternal and newborn outcomes. Cochrane Database Syst. Rev. 2015 Oct 27;2015(10): CD 008666. doi: 10.1002/14651858.CD008666.pub3

78. Domellöf M, Thorsdottir I, Thorstensen K. Health effects of different dietary iron intakes: a systematic literature review for the 5th Nordic Nutrition Recommendations. Food Nutr Res. 2013 Jul 12;57. doi: 10.3402/fnr.v57i0.21667

79. The Food Fortification Initiative. https://www.ffinetwork.org/

80. Weekly dietary supplements: iron and folic acid for women of reproductive age. Role in promoting optimal maternal and child health. WHO. 2009.

81. Intermittent regimen for menstruating women taking iron and folic acid supplements. WHO guidance. 2012.

82. Short MW, Domagalski JE. Iron deficiency anemia: evaluation and management. Am Fam Physician. 2013 Jan 15;87(2):98–104.

83. Weekly iron and folic acid supplementation as an anaemia-prevention strategy in women and adolescent girls: lessons learnt from implementation of programmes among non-pregnant women of reproductive age. Geneva: World Health Organization; 2018 (WHO/NMH/NHD/18.8.

84. Guideline: Iron supplementation in postpartum women. Geneva: World Health Organization; 2016.

85. Guideline: Daily iron supplementation in infants and children. Geneva: World Health Organization; 2016

86. Cantor AG, Bougatsos C, Dana T, Blazina I, McDonagh M. Routine iron supplementation and screening for iron deficiency anemia in pregnancy: a systematic review for the U. S. Preventive Services Task Force. Ann. Intern. Med. 2015 Apr 21;162(8):566–76. doi: 10.7326/M14–2932

87. Federal clinical guidelines. Diagnosis, prevention and treatment of iron deficiency conditions in pregnant women and puerperas. 2013.

88. Gromova O. A., Torshin I. Yu., Tomilova I. K., Fedotova L. E. Clinical pharmacology of zinc and iron interactions. Medical business. 2010; 1:31–41.

89. Winter WE, Bazydlo LA, Harris NS. The molecular biology of human iron metabolism. Lab Med. 2014 Spring;45(2):92–102. doi: 10.1309/lmf28s2gimxnwhmm

90. Orlova S. V. Chelate complexes MP 2nd add. Edition. Moscow, 2017.

91. Orlova S. V., Nikitina E. A., Prokopenko E. V., Vodolazkaya A. N. Iron deficiency management: diet, dietary supplements or drugs? Therapy. 2021;1:162–171. doi: https://dx.doi.org/10.18565/therapy.2021.1.162-171

92. Sunawang, Utomo B, Hidayat A, Kusharisupeni, Subarkah. Preventing low birthweight through maternal multiple micronutrient supplementation: a cluster-randomized, controlled trial in Indramayu, West Java. Food. Nutr. Bull. 2009 Dec;30(4 Suppl): S 488–95. doi: 10.1177/15648265090304S 403

93. Haider BA, Bhutta ZA. Multiple-micronutrient supplementation for women during pregnancy. Cochrane Database Syst. Rev. 2017 Apr 13;4(4): CD 004905. doi: 10.1002/14651858.CD004905.pub5. Update in: Cochrane Database Syst Rev. 2019 Mar 14;3: CD 004905.

94. Keats EC, Haider BA, Tam E, Bhutta ZA. Multiple-micronutrient supplementation for women during pregnancy. Cochrane Database Syst. Rev. 2019 Mar 14;3(3): CD 004905. doi: 10.1002/14651858.CD004905.pub6

95. Allen LH. B vitamins in breast milk: relative importance of maternal status and intake, and effects on infant status and function. Adv Nutr. 2012 May 1;3(3):362–9. doi: 10.3945/an.111.001172

96. Kodentsova V. M., Vrzhesinskaya O. A. Science-based approaches to the selection and dosage of vitamin and mineral complexes. Traditsionnaya meditsina [Traditional medicine]. 2011; Vol. 5: 351–7 (in Russ.).

97. Jasti S, Siega-Riz AM, Cogswell ME, Hartzema AG, Bentley ME. Pill count adherence to prenatal multivitamin/mineral supplement use among low-income women. J. Nutr. 2005 May;135(5):1093–101. doi: 10.1093/jn/135.5.1093

98. Kodentsova V. M., Gmoshinskaya O. A. Vitamin profile of breast milk and its optimization. Doctor, 1–2015.


Review

For citations:


Orlova S.V., Nikitina E.A., Balashova N.V. The role of iron during pregnancy and lactation. Medical alphabet. 2022;(24):8-15. (In Russ.) https://doi.org/10.33667/2078-5631-2022-24-8-15

Views: 1849


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2078-5631 (Print)
ISSN 2949-2807 (Online)