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Страсти по омеге: роль омега‑3 ПНЖК во время беременности для здоровья потомства

https://doi.org/10.33667/2078-5631-2022-4-8-12

Аннотация

Основой нормального течения беременности является оптимальное питание как один из главных элементов здорового образа жизни. Многочисленными исследованиями установлено, что длинноцепочечные омега 3 полиненасыщенные жирные кислоты (ПНЖК) обладают разнообразной биологической активностью: противовоспалительной, антиоксидантной, иммуномодулирующей, противоаллергической, антитромботической, антисклеротической и т.д. Эйкозапентаеновая и докозагексаеновая жирные кислоты необходимы для нормального функционирования организма во время беременности и внутриутробного развития ребенка. Дефицит омега 3 ПНЖК ведет к нарушению нормального развития и физиологического формирования структур головного мозга, зрительного анализатора и иммунной системы плода. Применение омега 3 ПНЖК вовремя беременности благоприятно отражается как нанейропсихическом состоянии женщины, предотвращая депрессию, так и на психомоторном развитии ребенка, улучшении когнитивных функций. Важно обеспечить адекватное поступление данных соединений с пищей или биологически активными добавками к пище для обеспечения нормального течения и исходов беременности.

Об авторах

С. В. Орлова
ФГАОУ ВО «Российский университет дружбы народов»
Россия

Орлова Светлана Владимировна, доктор медицинских наук, профессор, заведующая кафедрой диетологии и клинической нутрициологии

Москва



Е. А. Никитина
ФГАОУ ВО «Российский университет дружбы народов»
Россия

Никитина Елена Александровна, кандидат медицинских наук, доцент кафедры диетологии и клинической нутрициологии

Москва



Е. В. Прокопенко
ООО «Инфитро»
Россия

Прокопенко Елена Валерьевна, эндокринолог, диетолог, методист лечебного отдела

Москва

 



Н. В. Балашова
ФГАОУ ВО «Российский университет дружбы народов»
Россия

Балашова Наталья Валерьевна, кандидат биологических наук, доцент кафедры диетологии и клинической нутрициологии

Москва



А. Н. Водолазкая
Австрийская клиника микронутриентной терапии Biogena
Россия

Водолазкая Ангелина Николаевна, диетолог-эндокринолог

Москва



А. Е. Пронина
Клиника «Медгород»
Россия

Пронина Олеся Евгеньевна, эндокринолог, диетолог, гинеколог

Москва



Список литературы

1. Плотникова Е.Ю., Синькова М.Н., Исаков Л.К. Роль омега‑3 ненасыщенных кислот в профилактике и лечении различных заболеваний (часть 1). Лечащий врач. 2018. № 7. с. 63–67.

2. Сидельникова В.М. Применение омега‑3 ПНЖК для профилактики и комплексного лечения тромбофилических нарушений при беременности. Русский медицинский журнал. 2008. Том 16. № 6. c. 1–6.

3. Aparicio E, Martín-Grau C, Hernández-Martinez C, Voltas N, Canals J, Arija V. Changes in fatty acid levels (saturated, monounsaturated and polyunsaturated) during pregnancy. BMC Pregnancy Childbirth. 2021 Nov 17; 21 (1): 778. DOI: 10.1186/s12884–021–04251–0.

4. Hibbeln JR, Spiller P, Brenna JT, Golding J, Holub BJ, Harris WS, Kris-Etherton P, Lands B, Connor SL, Myers G, Strain JJ, Crawford MA, Carlson SE. Relationships between seafood consumption during pregnancy and childhood and neurocognitive development: Two systematic reviews. Prostaglandins Leukot Essent Fatty Acids. 2019 Dec; 151: 14–36. DOI: 10.1016/j.plefa.2019.10.002.

5. Steenweg-de Graaff J, Tiemeier H, Ghassabian A, Rijlaarsdam J, Jaddoe VW, Verhulst FC, Roza SJ. Maternal Fatty Acid Status During Pregnancy and Child Autistic Traits: The Generation R Study. Am J Epidemiol. 2016 May 1; 183 (9): 792–9. DOI: 10.1093/aje/kwv263.

6. Montes R, Chisaguano AM, Castellote AI, Morales E, Sunyer J, López-Sabater MC. Fatty-acid composition of maternal and umbilical cord plasma and early childhood atopic eczema in a Spanish cohort. Eur J Clin Nutr. 2013 Jun; 67 (6): 658–63. DOI: 10.1038/ejcn.2013.68.

7. Notenboom ML, Mommers M, Jansen EH, Penders J, Thijs C. Maternal fatty acid status in pregnancy and childhood atopic manifestations: KOALA Birth Cohort Study. Clin Exp Allergy. 2011 Mar; 41 (3): 407–16. DOI: 10.1111/j.1365–2222.2010.03672.x

8. Jochems SH, Gielen M, Rump P, Hornstra G, Zeegers MP. Potential programming of selected cardiometabolic risk factors at childhood by maternal polyunsaturated fatty acid availability in the MEFAB cohort. Prostaglandins Leukot Essent Fatty Acids. 2015 Sep; 100: 21–7. DOI: 10.1016/j.plefa.2015.06.001.

9. Vidakovic AJ, Jaddoe VW, Voortman T, Demmelmair H, Koletzko B, Gaillard R. Maternal plasma polyunsaturated fatty acid levels during pregnancy and childhood lipid and insulin levels. Nutr Metab Cardiovasc Dis. 2017 Jan; 27 (1): 78–85. DOI: 10.1016/j.numecd.2016.10.001.

10. Kikut J, Komorniak N, Ziętek M, Palma J, Szczuko M. Inflammation with the participation of arachidonic (AA) and linoleic acid (LA) derivatives (HETEs and HODEs) is necessary in the course of a normal reproductive cycle and pregnancy. J Reprod Immunol. 2020 Sep; 141: 103177. DOI: 10.1016/j.jri.2020.103177.

11. Vaz JS, Kac G, Nardi AE, Hibbeln JR. Omega‑6 fatty acids and greater likelihood of suicide risk and major depression in early pregnancy. J Affect Disord. 2014 Jan; 152–154: 76–82. DOI: 10.1016/j.jad.2013.04.045. Epub 2013 May 31. Erratum in: J Affect Disord. 2016 Jan 15; 190:893.

12. Hoge A, Tabar V, Donneau AF, Dardenne N, Degée S, Timmermans M, Nisolle M, Guillaume M, Castronovo V. Imbalance between Omega‑6 and Omega‑3 Polyunsaturated Fatty Acids in Early Pregnancy Is Predictive of Postpartum Depression in a Belgian Cohort. Nutrients. 2019 Apr 18; 11 (4): 876. DOI: 10.3390/nu11040876.

13. Szczuko M, Kikut J, Komorniak N, Bilicki J, Celewicz Z, Ziętek M. The Role of Arachidonic and Linoleic Acid Derivatives in Pathological Pregnancies and the Human Reproduction Process. Int J Mol Sci. 2020 Dec 17; 21 (24): 9628. DOI: 10.3390/ijms21249628.

14. Achamrah N, Ditisheim A. Nutritional approach to preeclampsia prevention. Curr Opin Clin Nutr Metab Care. 2018 May; 21 (3): 168–173. DOI: 10.1097/MCO.0000000000000462.

15. Hoge A, Bernardy F, Donneau AF, Dardenne N, Degée S, Timmermans M, Nisolle M, Guillaume M, Castronovo V. Low omega‑3 index values and monounsaturated fatty acid levels in early pregnancy: an analysis of maternal erythrocytes fatty acids. Lipids Health Dis. 2018 Apr 2; 17 (1): 63. DOI: 10.1186/s12944–018–0716–6.

16. Aparicio E, Martín-Grau C, Bedmar C, Serrat Orus NS, Basora J, Arija V, The Eclipses Study Group. Maternal Factors Associated with Levels of Fatty Acids, specifically n‑3 PUFA during Pregnancy: ECLIPSES Study. Nutrients. 2021 Jan 22; 13 (2): 317. DOI: 10.3390/nu13020317.

17. Haggarty P. Fatty acid supply to the human fetus. Annu Rev Nutr. 2010 Aug 21; 30: 237–55. DOI: 10.1146/annurev.nutr.012809.104742.

18. Burdge GC, Wootton SA. Conversion of alpha-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women. Br J Nutr. 2002 Oct; 88 (4): 411–20. DOI: 10.1079/BJN2002689.

19. Dubé E, Gravel A, Martin C, Desparois G, Moussa I, Ethier-Chiasson M, Forest JC, Giguère Y, Masse A, Lafond J. Modulation of fatty acid transport and metabolism by maternal obesity in the human full-term placenta. Biol Reprod. 2012 Jul 19; 87 (1): 14, 1–11. DOI: 10.1095/biolreprod.111.098095.

20. Stewart F, Rodie VA, Ramsay JE, Greer IA, Freeman DJ, Meyer BJ. Longitudinal assessment of erythrocyte fatty acid composition throughout pregnancy and post-partum. Lipids. 2007 Apr; 42 (4): 335–44. DOI: 10.1007/s11745–006–3005–5.

21. Duttaroy AK, Basak S. Maternal dietary fatty acids and their roles in human placental development. Prostaglandins Leukot Essent Fatty Acids. 2020 Apr; 155: 102080. DOI: 10.1016/j.plefa.2020.102080.

22. Marik PE, Varon J. Omega‑3 dietary supplements and the risk of cardiovascular events: a systematic review. Clin Cardiol. 2009 Jul; 32 (7): 365–72. DOI: 10.1002/clc.20604.

23. Markhus MW, Rasinger JD, Malde MK, Frøyland L, Skotheim S, Braarud HC, Stormark KM, Graff IE. Docosahexaenoic Acid Status in Pregnancy Determines the Maternal Docosahexaenoic Acid Status 3-, 6- and 12 Months Postpartum. Results from a Longitudinal Observational Study. PLoS One. 2015 Sep 2; 10 (9): e0136409. DOI: 10.1371/journal.pone.0136409.

24. Kohlboeck G, Glaser C, Tiesler C, Demmelmair H, Standl M, Romanos M, Koletzko B, Lehmann I, Heinrich J; LISAplus Study Group. Effect of fatty acid status in cord blood serum on children’s behavioral difficulties at 10 y of age: results from the LISAplus Study. Am J Clin Nutr. 2011 Dec; 94 (6): 1592–9. DOI: 10.3945/ajcn.111.015800.

25. Calder P. Omega‑3 fatty acids and inflammation: Impact on heart disease, irritable bowel syndrome and asthma. Presented at the omega‑3 fatty acids: Recommendations for therapeutics and prevention symposium. May 21, 2005. New York.

26. Schachter HM, Reisman J, Tran K, Dales B, Kourad K, Barnes D, Sampson M, Morrison A, Gaboury I, Blackman J. Health effects of omega‑3 fatty acids on asthma. Evid Rep Technol Assess (Summ). 2004 Mar; (91): 1–7.

27. Schuchardt JP, Huss M, Stauss-Grabo M, Hahn A. Significance of long-chain polyunsaturated fatty acids (PUFAs) for the development and behaviour of children. Eur J Pediatr. 2010 Feb; 169 (2): 149–64. DOI: 10.1007/s00431–009–1035–8.

28. Julvez J, Méndez M, Fernandez-Barres S, Romaguera D, Vioque J, Llop S, Ibarluzea J, Guxens M, Avella-Garcia C, Tardón A, Riaño I, Andiarena A, Robinson O, Arija V, Esnaola M, Ballester F, Sunyer J. Maternal Consumption of Seafood in Pregnancy and Child Neuropsychological Development: A Longitudinal Study Based on a Population with High Consumption Levels. Am J Epidemiol. 2016 Feb 1; 183 (3): 169–82. DOI: 10.1093/aje/kwv195.

29. Palmer DJ, Sullivan T, Gold MS, Prescott SL, Heddle R, Gibson RA, Makrides M. Effect of n‑3 long chain polyunsaturated fatty acid supplementation in pregnancy on infants’ allergies in first year of life: randomised controlled trial. BMJ. 2012 Jan 30; 344: e184. DOI: 10.1136/bmj.e184.

30. Ouellet M, Emond V, Chen CT, Julien C, Bourasset F, Oddo S, LaFerla F, Bazinet RP, Calon F. Diffusion of docosahexaenoic and eicosapentaenoic acids through the blood-brain barrier: An in situ cerebral perfusion study. Neurochem Int. 2009 Dec; 55 (7): 476–82. DOI: 10.1016/j.neuint.2009.04.018.

31. Chen CT, Domenichiello AF, Trépanier MO, Liu Z, Masoodi M, Bazinet RP. The low levels of eicosapentaenoic acid in rat brain phospholipids are maintained via multiple redundant mechanisms. J Lipid Res. 2013 Sep; 54 (9): 2410–22. DOI: 10.1194/jlr.M038505.

32. Middleton P, Gomersall JC, Gould JF, Shepherd E, Olsen SF, Makrides M. Omega‑3 fatty acid addition during pregnancy. Cochrane Database Syst Rev. 2018 Nov 15; 11 (11): CD003402. DOI: 10.1002/14651858.CD003402.pub3.

33. So J, Wu D, Lichtenstein AH, Tai AK, Matthan NR, Maddipati KR, Lamon-Fava S. EPA and DHA differentially modulate monocyte inflammatory response in subjects with chronic inflammation in part via plasma specialized pro-resolving lipid mediators: A randomized, double-blind, crossover study. Atherosclerosis. 2021 Jan; 316: 90–98. DOI: 10.1016/j.atherosclerosis.2020.11.018.

34. Skulas-Ray AC, Wilson PWF, Harris WS, Brinton EA, Kris-Etherton PM, Richter CK, Jacobson TA, Engler MB, Miller M, Robinson JG, Blum CB, Rodriguez-Leyva D, de Ferranti SD, Welty FK; American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Lifestyle and Cardiometabolic Health; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; and Council on Clinical Cardiology. Omega‑3 Fatty Acids for the Management of Hypertriglyceridemia: A Science Advisory from the American Heart Association. Circulation. 2019 Sep 17; 140 (12): e673–e691. DOI: 10.1161/CIR.0000000000000709.

35. Hellberg R. S., DeWitt C.A.M. and Morrissey M. T. Risk-Benefit Analysis of Seafood Consumption: A Review. Comprehensive Reviews in Food Science and Food Safety, 2012; 11: 490–517. https://doi.org/10.1111/j.1541–4337.2012.00200.x

36. МУ 2.3.7.2125–06 «Социально-гигиенический мониторинг. Контаминация продовольственного сырья и пищевых продуктов химическими веществами. сбор, обработка и анализ показателей». https://fcgie.ru/osnovnye_dokumenty_po_vedeniyu_sgm.html. MU2.3.7.2125–06 “Social and hygienic monitoring. Contamination of food raw materials and food products with chemicals. collection, processing and analysis of indicators”. https://fcgie.ru/osnovnye_dokumenty_po_vedeniyu_sgm.html.

37. US Department of Agriculture. USDA National Nutrient Database for Standard Reference: Release 18 (2005). US Department of Agriculture, Agricultural Research Service, 2012.

38. Mozaffarian D, Rimm EB. Fish intake, contaminants, and human health: evaluating the risks and the benefits. JAMA. 2006 Oct 18; 296 (15): 1885–99. DOI: 10.1001/jama.296.15.1885.

39. Domingo JL, Bocio A, Falcó G, Llobet JM. Benefits and risks of fish consumption Part I. A quantitative analysis of the intake of omega‑3 fatty acids and chemical contaminants. Toxicology. 2007 Feb 12; 230 (2–3): 219–26. DOI: 10.1016/j.tox.2006.11.054.

40. Dórea JG. Exposure to mercury during the first six months via human milk and vaccines: modifying risk factors. Am J Perinatol. 2007 Aug; 24 (7): 387–400. DOI: 10.1055/s‑2007–982074.

41. Section on Breastfeeding. Breastfeeding and the use of human milk. Pediatrics. 2012 Mar; 129 (3): e827–41. DOI: 10.1542/peds.2011–3552.

42. Foran SE, Flood JG, Lewandrowski KB. Measurement of mercury levels in concentrated over-the-counter fish oil preparations: is fish oil healthier than fish? Arch Pathol Lab Med. 2003 Dec; 127 (12): 1603–5. DOI: 10.5858/2003–127–1603-MOMLIC.

43. Melanson SF, Lewandrowski EL, Flood JG, Lewandrowski KB. Measurement of organochlorines in commercial over-the-counter fish oil preparations: implications for dietary and therapeutic recommendations for omega‑3 fatty acids and a review of the literature. Arch Pathol Lab Med. 2005 Jan; 129 (1): 74–7. DOI: 10.5858/2005–129–74-MOOICO.

44. Koletzko B, Cetin I, Brenna JT; Perinatal Lipid Intake Working Group; Child Health Foundation; Diabetic Pregnancy Study Group; European Association of Perinatal Medicine; European Association of Perinatal Medicine; European Society for Clinical Nutrition and Metabolism; European Society for Paediatric Gastroenterology, Hepatology and Nutrition, Committee on Nutrition; International Federation of Placenta Associations; International Society for the Study of Fatty Acids and Lipids. Dietary fat intakes for pregnant and lactating women. Br J Nutr. 2007 Nov; 98 (5): 873–7. DOI: 10.1017/S0007114507764747.

45. Simopoulos AP, Leaf A, Salem N Jr. Workshop statement on the essentiality of and recommended dietary intakes for Omega‑6 and Omega‑3 fatty acids. Prostaglandins Leukot Essent Fatty Acids. 2000 Sep; 63 (3): 119–21. DOI: 10.1054/plef.2000.0176.

46. Koletzko B, Lien E, Agostoni C, Böhles H, Campoy C, Cetin I, Decsi T, Dudenhausen JW, Dupont C, Forsyth S, Hoesli I, Holzgreve W, Lapillonne A, Putet G, Secher NJ, Symonds M, Szajewska H, Willatts P, Uauy R; World Association of Perinatal Medicine Dietary Guidelines Working Group. The roles of long-chain polyunsaturated fatty acids in pregnancy, lactation and infancy: review of current knowledge and consensus recommendations. J Perinat Med. 2008; 36 (1): 5–14. DOI: 10.1515/JPM.2008.001.

47. Koletzko B, Bauer CP, Bung P, Cremer M, Flothkötter M, Hellmers C, Kersting M, Krawinkel M, Przyrembel H, Rasenack R, Schäfer T, Vetter K, Wahn U, Weissenborn A, Wöckel A. German national consensus recommendations on nutrition and lifestyle in pregnancy by the ‘Healthy Start – Young Family Network’. Ann Nutr Metab. 2013; 63 (4): 311–22. DOI: 10.1159/000358398.

48. Bisgaard H, Stokholm J, Chawes BL, Vissing NH, Bjarnadóttir E, Schoos AM, Wolsk HM, Pedersen TM, Vinding RK, Thorsteinsdóttir S, Følsgaard NV, Fink NR, Thorsen J, Pedersen AG, Waage J, Rasmussen MA, Stark KD, Olsen SF, Bønnelykke K. Fish Oil-Derived Fatty Acids in Pregnancy and Wheeze and Asthma in Offspring. N Engl J Med. 2016 Dec 29; 375 (26): 2530–9. DOI: 10.1056/NEJMoa1503734.

49. Zhang GQ, Liu B, Li J, Luo CQ, Zhang Q, Chen JL, Sinha A, Li ZY. Fish intake during pregnancy or infancy and allergic outcomes in children: A systematic review and meta-analysis. Pediatr Allergy Immunol. 2017 Mar; 28 (2): 152–161. DOI: 10.1111/pai.12648.

50. Substances affirmed as Generally Recognized as Safe: Menhaden oil. Department of Health and Human Services, US Food and Drug Administration. www.fda.gov/OHRMS/DOCKETS/98fr/05–5641.htm (Accessed on June 30, 2008).


Рецензия

Для цитирования:


Орлова С.В., Никитина Е.А., Прокопенко Е.В., Балашова Н.В., Водолазкая А.Н., Пронина А.Е. Страсти по омеге: роль омега‑3 ПНЖК во время беременности для здоровья потомства. Медицинский алфавит. 2022;(4):8-12. https://doi.org/10.33667/2078-5631-2022-4-8-12

For citation:


Orlova S.V., Nikitina E.A., Prokopenko E.V., Balashova N.V., Vodolazkaya A.N., Pronina O.E. Passion for omega: Role of omega‑3 PUFAs during pregnancy for health of offspring. Medical alphabet. 2022;(4):8-12. (In Russ.) https://doi.org/10.33667/2078-5631-2022-4-8-12

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