Complications and causes of mortality in patients with primary necrotizing systemic vasculitis
https://doi.org/10.33667/2078-5631-2021-33-30-34
Abstract
The article reviews the clinical symptoms, main complications in patients with ANCA-associated systemic vasculitis (granulomatous with polyangiitis, microscopic polyangiitis, eosinophilic granulomatous with polyangiitis) and polyarteritis nodosa during the first three years of the disease. We evaluated the relationship between complications and long-term glucocorticosteroid therapy. Patients with granulomatosis had the most unfavourable course of the disease with a high risk of complications. A high incidence of ischemic strokes and chronic kidney disease in patients with microscopic polyangiitis has been identified. We also analyzed cases of lethal outcomes in patients with primary systemic vasculitis.
About the Authors
V. I. Mazurov
North-Western State Medical University n. a. I. I. Mechnikov
Russian Federation
Russian Federation
Mazurov Vadim I., DM Sci (habil.), RAS academician, head of Dept
Saint Petersburg
I. B. Belyaeva
Clinical Rheumatology Hospital No. 25; North-Western State Medical University n. a. I. I. Mechnikov
Russian Federation
Russian Federation
Belyaeva Irina B., DM Sci (habil.), professor, rheumatologist; associate professor
at Dept
Saint Petersburg
A. L. Chudinov
Clinical Rheumatology Hospital No. 25
Russian Federation
Russian Federation
Chudinov Anton L., PhD Med, head of Dept
Saint Petersburg
O. V. Inamova
Clinical Rheumatology Hospital No. 25
Russian Federation
Russian Federation
Inamova Oksana V., PhD Med, chief physician
Saint Petersburg
References
1. Clinical rheumatology. 3rd edition, revised and enlarged. A guide for doctors. Under. ed. V. I. Mazurov. M.: E-noto, 2021. P. 696.
2. Mazurov V. I. Rheumatology. Pharmacotherapy without mistakes. A guide for physicians, ed. V. I. Mazurov, O. M. Lesnyak: E-noto, Moscow, 2017. P. 479–505.
3. Mahr A, Guillevin L. Prevalences of polyarteriitis nodosa, microscopic polyangiitis, Wegener's granulomatosis and Churg-Strauss syndrome in a French urban multiethnic population in 2000: a capture-recapture estimate. Arthritis Rheum. 2004, 51: P. 92–99.
4. Watts RA, Scott DGI. Epidemiology of vasculitis. Oxford: Oxford University Press, 2008. P. 7–22.
5. Richard A. Watts, David G. I. Scott. Vasculitis in Clinical Practice Springer-Verlag New York, 2010. P. 71–77.
6. Nasonov E. L., Baranov A. A., Shilkina N. P. Vasculitis and vasculopathies. Yaroslavl: Upper Volga, 1999. Pp. 340–347.
7. Exley AR, Bacon PA, Luqmani RA et al. Development and initial validation of the Vasculitis Damage Index. Arthritis Rheum 1997; 40: 371–380.
8. Booth AD, Almond MK, Burns A et al. Outcome of ANCA-associated renal vasculitis: a 5-year retrospective study. Am J Kidney Dis 2003; 41: 776–784.
9. Drooger J.C, A Dees, and A.J.G Swaak. ANCA-Positive Patients: The Influence of PR 3 and MPO Antibodies on Survival Rate and The Association with Clinical and Laboratory Characteristics. Open Rheumatol J. 2009; 3: 14–17.
Review
For citations:
Mazurov V.I., Belyaeva I.B., Chudinov A.L., Inamova O.V. Complications and causes of mortality in patients with primary necrotizing systemic vasculitis. Medical alphabet. 2021;(33):30-34. (In Russ.) https://doi.org/10.33667/2078-5631-2021-33-30-34
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