Preview

Medical alphabet

Advanced search

System of digestion under antipsychotic therapy (literature review). Part IV: iatrogenic pathology of liver (effect of typical antipsychotics)

Abstract

The antipsychotic preparations which are widely used in medical practice possess an extensive range of the negative side effects including operating on organs of system of digestion. In the fourth of the offered review the pathology of the liver associated with reception of separate concrete antipsychotic medicines of the first generation is considered.

About the Author

V. P. Volkov
Tver Centre for Legal Expertise
Russian Federation


References

1. Akesson H. O. [3 cases of jaundice related to Nozinan treatment] // Sven. Lakartidn.- 1960.- Vol. 57.- 3607-3608.

2. Alcalâ-Santaella R., Pacheco A. F., Robles J. [Apropos of primary biliary cirrhosis induced by chlorpromazine and its therapy with cholestyramine] // Rev. Clin. Esp.- 1968.- Vol. 108, N5.- P. 366-372.

3. Antipsychotic Agents. [Электронный ресурс].- URL: http://livertox.nih.gov/AntipsychoticAgents.htm (дата обращения: 15.10.2016).

4. Ayd F. J. Jr. Chlorpromazine: ten years' experience // JAMA.- 1963.- Vol. 184.- P. 51-54.

5. Barancik M., Brandborg L. L., Albion M. J. Thioridazine-induced cholestasis // JAMA.- 1967.- Vol. 200, N 1.- P. 69-70.

6. Bartholomew L. G., Cain J. C. Chlorpromazine hepatitis without clinical jaundice // Proc. Staff. Meet. Mayo Clin.- 1956.- Vol. 31, N7.- P. 201-204.

7. Beattie A. S., Farris J. M., Frempter G. R. Hepatohypercholesterolemic cirrhosis: report of a case implicating chlorpromazine as the etiologic agent// Calif. Med.- 1959.- Vol. 91.- P. 154-155.

8. Bhatia S. C., Banta L.E., Ehrlich D. W. Molindone andhepatotoxicity //DrugIntell. Clin. Pharm.- 1985.- Vol. 19, N 10.- P. 744-746.

9. Block S.L. Jaundice following thioridazine administration // Am. J. Psychiatry.- 1962.- Vol. 119.- P. 77. doi: 10.1176/ajp.119.1.77

10. Boardman R. H. Fatal case of toxic hepatitis implicating chlorpromazine.- Br. Med. J.- 1954.- Vol. 2, N4887.- P. 579.

11. Bolton B. H. Prolonged chlorpromazine jaundice // Am.J. Gastroenterol.- 1967.- Vol. 48, N6.- P. 497-503.

12. Characteristics of idiosyncratic drug-induced liver injury in children: results from the DILIN prospective study / J. P. Molleston, R. J. Fontana, M.J. Lopez [et al.] // J. Pediatr. Gastroenterol. Nutr.- 2011.- Vol. 53, N2.- P. 182-189.

13. Chlorpromazine. [Электронный ресурс].- URL: livertox.nih.gov/Chlorpromazine.htm (дата обращения: 15.10.2016).

14. Chlorpromazine-induced cholestatic liver disease with ductopenia / A. Chlumskâ, R. Curik, L. Boudovâ [etal.] // Cesk. Patol. - 2001. - Vol. 37, N3.- P. 118-122.

15. Chlorpromazine-induced vanishing bile duct syndrome leading to biliary cirrhosis / D. Moradpour, J. Altorfer, R. Flury [et al.] // Hepatology.- 1994.- Vol. 20, N6.- P. 1437-1441.

16. [Cholestatic hepatitis in a patient taking levomepromazine] / H. Pierson, M. A. Preiss, F. Penin [et al.] // Ann. Gastroenterol. Hepatol. (Paris).- 1987.- Vol. 23, N2.- P. 101.

17. Cook GC, Sherlock S. Jaundice and its relation to therapeutic agents // Lancet.- 1965.- Vol. 1, N7378.- P. 175-179.

18. Crane G. E. A review of clinical literature on haloperidol// Int. J. Neuropsychiatry.- 1967. - Vol. 3, Suppl 1.- P. 110-127.

19. Crause J. Jaundice associated with haloperidol // Lancet.- 1963.- Vol. 2, N 7313.- P. 890-891.

20. [Cytolytic hepatitis during treatment with phenothiazines: apropos of a case] / G. Mesure, F. Bayle, J.M. Vanelle [et al.] // Encephale.- 1996.- Vol. 22, N5.- P. 388-390.

21. DePaulo J. R. Jr., Ayd F.J. Jr. Loxapine: fifteen years' clinical experience // Psychosomatics. - 1982.- Vol. 23, N3.- P. 261-271.

22. Dincsoy H. P., Saelinger D. A. Haloperidol-induced chronic cholestatic liver disease // Gastroenterology.- 1982.- Vol. 83, N3.- P. 694-700.

23. Double-blind maintenance safety and effectiveness findings from the treatment of early-onsetschizophrenia spectrum (TEOSS) study / R. L. Findling, J. L. Johnson, J. McClellan [et al.] // J. Am. Acad. Child. Adolesc. Psychiatry.- 2010.- Vol. 49, N6.- P. 583-594.

24. Effect of chlorpromazine on isolated rat hepatocytes / S. C. Tsao, T. Iga, Y. Sugiyama [et al.] // Biochem. Pharmacol.- 1982.- Vol. 31, N4.- P. 491-497.

25. Fluphenazine. [Электронный ресурс].- URL: http://livertox.nih.gov/Fluphenazine.htm (дата обращения: 15.10.2016).

26. Fuller C. H. A death due to chlorpromazine hepatitis // BMQ.- 1959.- Vol. 10, N 1.- P. 13-16.

27. Gerle B. Clinical observations of the side effects of haloperidol// Acta Psychiatr. Scand.- 1964.- Vol. 40. - P. 65-76.

28. Grytting G. [Toxic liver damage due to largactil (chlorpromazine)] // Nord. Med.- 1954. - Vol. 52, N49.- P. 1699-1701.

29. Gupta N.N., Pant S. S., Mehrotra R.M. Toxic effects of chlorpromazine with special reference to jaundice // Indian. J. Med. Sci.- 1962. - Vol. 16.- P. 315-323.

30. Haloperidol. [Электронный ресурс].- URL: http://livertox.nih.gov/Haloperidol.htm (дата обращения: 15.10.2016).

31. Haloperidol-induced liver disease / C.M. Fuller, S. Yassinger, P. Donlon [et al.] // West J. Med.- 1977.- Vol. 127, N6.- P. 515-518.

32. Hansen T. E., Casey D. E., Hoffman W.F. Neuroleptic intolerance // Schizophr. Bull.- 1997.- Vol. 23, N4.- P. 567-582.

33. Hargreaves T. Cholestatic drugs and bilirubin metabolism // Nature.- 1965.- Vol. 206, N 980.- P. 154-156.

34. Hartnett B. S. Liver damage and eosinophilia following chlorpromazine therapy; report of a case // Br. Med. J.- 1955.-Vol. I, N4928.-P. 1458-1459.

35. [Hepatic tolerance of atypical antipsychotic drugs] / G. Dumortier, W. Cabaret, L. Stamatiadis [et al.] // Encephale.- 2002.- Vol. 28, N 6, Pt 1.- P. 542-551.

36. Hepatotoxicity of clozapine / M. Hummer, M. Kurz, I. Kurzthaler [et al.] // J. Clin. Psychopharmacol.- 1997. - Vol. 17, N4. - P. 314-317.

37. Herron G., Bourdo S. Jaundice secondary to promazine, and an analysis of possible cross sensitivities between phenothiazine derivatives // Gastroenterology.- 1960.- Vol. 38.- P. 87-90.

38. Hollister L. E. Allergy to chlorpromazine manifested by jaundice // Am. J. Med.- 1957. - Vol. 23, N6.- P. 870-879.

39. Holt RJ. Fluphenazine decanoate-induced cholestatic jaundice and thrombocytopenia // Pharmacotherapy.- 1984.- Vol. 4, N4.- P. 227-229.

40. Hurt P., Wegmann T. [Protracted Largactil jaundice developing into primary biliary cirrhosis] // Acta Hepatosplenol.- 1961.- Vol. 8. - P. 87-95.

41. Ishak K. G., Irey N. S. Hepatic injury associated with thephenothiazines. Clinicopathologic and follow-up study of 36 patients // Arch. Pathol.- 1972.- Vol. 93, N4.- P. 283-304.

42. Jacobson J. R., Turkel S. B. Elevated liver enzymes associated with fluphenazine used to manage delirium symptoms in infants // J. Child. Adolesc. Psychopharmacol.- 2013. - Vol. 23, N7. - P. 513-514. doi: 10.1089/ cap.2013.0047

43. Kane F. J. Jr., Moore L. P. Hepatotoxicity occurring with thioridazine therapy // South Med. J.- 1971.- Vol. 64, N5.- P. 573.

44. Kemp J. A. Jaundice occurring during administration of promazine // Gastroenterology.- 1957.- Vol. 32, N5.- P. 937-938.

45. Kohn N., Myerson R. M. Cholestatic hepatitis associated with trifluoperazine // N. Engl. J. Med.- 1961.- Vol. 264.- P. 549-550. doi: 10.1056/NEJM196103162641107

46. Kohn N., Myerson R.M. Xanthomatous biliary cirrhosis following chlorpromazine // Am. J. Med.- 1961. - Vol. 31, N4. - P. 665-670. doi: 10.1016/0002-9343(61)90150-4

47. Kristensen O. [Icterus induced by thioridazine (Melleril). Report of 1 case] // Tidsskr. Nor. Laegeforen.- 1975. - Vol. 95, N33. - P. 1910-1911.

48. Larrey D. Epidemiology and individual susceptibility to adverse drug reactions affecting the liver // Semin. Liver Dis. - 2002. - Vol. 22, N 2.- P. 145-155. doi: 10.1055/s-2002-30105

49. Larry D., Ripault M. P. Hepatotoxicity of psychotropic drugs and drugs of abuse // Drug-induced liver disease / N. Kaplowitz, L. D. DeLeve (eds.). - 3rd ed. - Amsterdam: Elsevier, 2013.- P. 447-462.

50. Leipzig R. M. Gastrointestinal and hepatic effects of psychotropic drugs // Adverse Effects of Psychotropic Drugs / J. A. Lieberman, J. M. Kane (eds.).-NY: Guilford Press, 1992.- P. 408-430.

51. Lok A. S., Ng I. O. Prochlorperazine-induced chronic cholestasis // J. Hepatol.- 1988.- Vol. 6, Is 3.- P. 369-373. doi: 10.1016/S 0168-8278(88)80056-4

52. Long-term study of molindone hydrochloride in chronic schizophrenics / R. Kellner, R. T. Rada, A. Egelman [etal.] // Curr. Ther. Res. Clin. Exp.- 1976.- Vol. 20, N 5.- P. 686-694.

53. Loxapine. [Электронный ресурс].- URL: h ttp://www. livertox. n ih.gov/Loxapin e. htm (дата обращения: 15.10.2016).

54. Loxapine: a review of its pharmacological properties and therapeutic efficacy as an antipsychotic agent/ R. C. Heel, R. N. Brogden, T. M. Speight [et al.] // Drugs.- 1978.- Vol. 15, N 3.- P. 198-217.

55. Margulies A. I., Berris B. Jaundice associated with the administration of trifluoperazine // Can. Med. Assoc. J.- 1968.- Vol. 98, N. 22.- P. 1063-1064.

56. Marivick K. F., Taylor M., Walker S. W. Antipsychotics and abnormal liver function tests: systematic review // Clin. Neuropharmacol.- 2012.- Vol. 35, N5.- P. 244-253. doi: 10.1097/ WNF.0b013e31826818b6

57. McQueen E.G. Toxic effects of phenothiazine tranquillizers // N. 2. Med. J.- 1963. - Vol. 62.- P. 460-462.

58. Mechanic R. C., Meyers L. Chlorpromazine-type cholangitis; report of a case occurring after the administration of prochlorperazine // N. Engl. J. Med.- 1958.- Vol. 259, N 16.- P. 778-780. doi: 10.1056/NEJM195810162591607

59. Melrose A. G., Roy J. R. Late prognosis of chlorpromazine jaundice // Br. Med. J.- 1959. - Vol. 1, N5125.- P. 818-819.

60. Molecular cytotoxic mechanisms of chlorpromazine in isolated rat hepatocytes / S. L. MacAllister, C. Young, A. Guzdek [etal.] // Can. J. Physi ol. Pharmacol.- 2013. - Vol. 91, N 1.- P. 56-63. doi: 10.1139/cjpp-2012-0223

61. Molindone. [Электронный ресурс].- URL: http://www.livertox.nih.gov/Molindone.htm (дата обращения: 15.10.2016).

62. Morera Prat J., Vidal Pla R., Mari M. L. [Primary biliary cirrhosis after a prolonged ingestion of chlorpromazine] // Rev. Clin. Esp.- 1976. - Vol. 142, N5.- P. 483-485.

63. Munyon W. H., Salo R., Briones D. F. Cytotoxic effects of neuroleptic drugs // Psychopharmacology (Berl.).- 1987.- Vol. 91, N2.- P. 182-188.

64. Norris T. S. Promethazine and drug-induced jaundice // Lancet.- 1963.- Vol. 1, N7277.- P. 394.

65. Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells / S. Anthérieu, P. Bachour-El Azzi, J. Dumont [et al.] // Hepatology.- 2013.- Vol. 57, N4.- P. 1518-1529. doi: 10.1002/hep.26160

66. Pantel J., Schröder J. Acute hepatitis, rhabdomyolisis and pancytopenia associated with perazine therapy // Pharmacopsychiatry.- 1996.- Vol. 29, N 1. - P. 43. doi: 10.1055/s-2007-979543

67. Patterson J. F. Amoxapine associated with hepatotoxicity // J. Clin. Psychopharmacol.- 1987.- Vol. 7, N 1.- P. 50-51.

68. Perphenazine. [Электронный ресурс]. - URL: http://livertox.nih.gov/Perphenazine.htm (дата обращения: 15.10.2016).

69. Pillans P. I. Drug associated hepatic reactions in New Zealand: 21 years experience // N.Z. Med. J.- 1996.- Vol. 109, N 1028.- P. 315-319.

70. Prochlorperazine. [Электронный ресурс].- URL: http://livertox.nih.gov/Prochlorperazine. htm (дата обращения: 15.10.2016).

71. Prochlorperazine-induced cholestasis in a patient with alpha-1 antitrypsin deficiency / A. L. Mindikoglu, A. Anantharaju, G. G. Hartman [et al.] // Hepatogastroenterology.- 2003.- Vol. 50, N53.- P. 1338-1340.

72. Ranek L. [A fatal case of prolonged chlorpromazine jaundice] // Ugeskr. Laeger.- 1964. - Vol. 126.- P. 1271-1274.

73. Read A. E., Harrison C. V., Sherlovk S. Chronic chlorpromazine jaundice: with particular reference to its relationship to primary biliary cirrhosis // Am. J. Med.- 1961.- Vol. 31. - P. 249-258.

74. Regal R.E., Bili J.E., Glazer H. M. Phenothiazine-induced cholestatic jaundice // Clin. Pharm.- 1987.- Vol. 6, N 10.- P. 787-794.

75. Relevance of liver enzyme elevations with four different neuroleptics: a retrospective review of 7,263 treatment courses /I. Gaertner, K. Altendorf, A. Batra [et al.] // J. Clin. Psychopharmacol.- 2001. - Vol. 21, N2. - P. 215-222.

76. Risk of acute liver injury associated with the use of drugs: a multicentre population survey / M. Sabaté, L. Ibánez, E. Pérez [et al.] // Aliment. Pharmacol. Ther. - 2007.- Vol. 25, N 12.- P. 1401-1409. doi: 10.1111/j.1365-2036.2007.03338.x

77. Rodin A. E., Robertson D.M. Fatal toxic hepatitis following chlorpromazine therapy; report of a case with autopsy findings // AMA Arch. Pathol.- 1958.- Vol. 66, N2.- P. 170-175.

78. Sex-dependent metabolic alterations of rat liver after 12-week exposition to haloperidol or clozapine / M. von Wilmsdorff, M. L. Bouvi er, U. Henning [et al.] // Horm. Metab. Res.- 2014. - Vol. 46, N 11. - P. 782-788. doi: 10.1055/ s-0034-1384605

79. Snyder S. Fluphenazine jaundice. Report of a case // Am.J. Gastroenterol.- 1980.- 73, N4.- P. 336-340.

80. Solomon F. A. Jr., Campagna F. A. Jaundice due to prochlorperazine (compazine) // Am. J. Med.- 1959.- Vol. 27.- P. 840-843.

81. Spirtes M.A., Guth P.S. Effects of chlorpromazine on biological membranes-I. Chlorpromazine-induced changes in liver mitochondria // Biochem. Pharmacol.- 1963.- Vol. 12.- P. 37-46.

82. Stine J. G., Chalasani N. Chronic liver injury induced by drugs: a systematic review // Liver Int. - 2015. - Vol. 35, N 11.- P. 2343-2353. doi: 10.1111/liv.12958

83. Suggestive evidence of hepatotoxicity concomitant with thioridazine hydrochloride use / M.J. Reinhart, R.M. Benson, S. K. Kwass[etal.] // JAMA.- 1966.- Vol. 197, N 10.- P. 767-769.

84. The effect of chlorpromazine, promethazine, and diphenhydramine on swelling of isolated liver mitochondria / E. E. Smith, C. Watanabe, J. Louie [et al.] // Biochem. Pharmacol.- 1964.- Vol. 13.- P. 643-657.

85. Thioridazine. [Электронный ресурс].- URL: http://livertox.nih.gov/Thioridazine.htm (дата обращения: 15.10.2016).

86. Trifluoperazine. [Электронный ресурс].- URL: http://livertox.nih.gov/Trifiuoperazine.htm (дата обращения: 15.10.2016).

87. Trifiuoperazine-induced cholestatic jaundice / V. Sharifi, S. Amini, P. Ghaeli[etal.] // Iran J. Psychiatry.- 2010 - Vol. 5, N3.- P. 117-118.

88. Urberg M. Thioridazine-induced non-icteric hepatotoxicity. Report of a case // J. Fam. Pract.- 1990.- Vol. 30, N3.- P. 342-343.

89. Walker C. O., Combes B. Biliary cirrhosis induced by chlorpromazine // Gastroenterology.- 1966.- Vol. 51, N5.- P. 631-640.

90. Walters G.M., Terrence C., Steckel R. Jaundice following administration of fluphenazine dihydrochloride // Am. J, Psychiatry.- 1963.- Vol. 120.- P. 81-82. doi:10.1176/ajp.120.1.81

91. Weiden P. L., Buckner C. D. Thioridazine toxicity. Agranulocytosis and hepatitis with encephalopathy // JAMA.- 1973.- Vol. 224, N4.- P. 518-520.

92. Wen B., Zhou M. Metabolic activation of the phenothiazine antipsychotics chlorpromazine and thioridazine to electrophilic iminoquinone species in human liver microsomes and recombinant P450s // Chem. Biol. Interact.- 2009. - Vol. 181, N 2. - P. 220-226. doi: 10.1016/j. cbi.2009.05.014

93. Werther J. L., Korelitz B. I. Chlorpromazine jaundice; analysis of twenty-two cases.- Am.J. Med.- 1957.- Vol. 22, N3.- P. 351-366.

94. Xanthomatous biliary cirrhosis following chlorpromazine, with observations indicating overproduction of cholesterol, hyperprothrombin-emia, and the development of portal hypertension / J. D. Myers, R. E. Olson, J. H. Lewis [et al.] // Trans. Assoc. Am. Physicians.- 1957.- Vol. 70. - P. 243-261.

95. Zatuchni J., Miller G. Jaundice during chlorpromazine therapy // N. Engl. J. Med.- 1954.- Vol. 251, N25.- P. 1003-1006. doi: 10.1056/ NEJM195412162512503

96. Zelman S. Liver cell necrosis in chlorpromazine jaundice (allergic cholangiolitis). A serial study of twenty-six needle biopsy specimens in nine patients // Am.J. Med.- 1959.- Vol. 27.- P. 708-729.

97. Zimmerman H. J. Hepatotoxicity: the adverse effects of drugs and other chemicals on the liver. - 2nd ed.- Philadelphia: Lippincott Williams a. Wilkins, 1999.- 789 p.


Review

For citations:


Volkov V.P. System of digestion under antipsychotic therapy (literature review). Part IV: iatrogenic pathology of liver (effect of typical antipsychotics). Medical alphabet. 2017;2(19):39-42. (In Russ.)

Views: 203


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2078-5631 (Print)
ISSN 2949-2807 (Online)