Expert-analytical approach to assessing activity of vitamin D based on determination of vitamin D associated links by indicators of water-electrolyte metabolism

The authors used the proposed method of mathematical and statistical processing of laboratory data (indicators of electrolyte metabolism and osteomarkers) of archived data of 82 patients with various bone diseases aged 9.90 ± 0.55 years compared the structural changes in the panel of ratios of individual electrolytes and the influence of individual indicators on them in personalized data, on the basis of which a conclusion was made about a single mechanism of coinciding influences in the exchange of bone tissue. At the same time, it was found that the complex of associated links detected by the vitamin influence on the panel of electrolyte ratios may differ signifcantly in some cases from each other. These differences consisted in highly pronounced differences in the activity of vitamin D in relation to various components of osteosynthesis and osteolysis, which are described in the modern literature. On this basis, the authors conclude that the used method (analytical system) allows to identify the functional connections of the dynamics of the indicator of vitamin D in individual cases with the dynamics of other indicators of bone, which signifcantly expands the informativeness of the results of laboratory examination of the patient in determining the leading systems the implementation of functional activity of the vitamin. The presented results justify the possibility of creating and describing different images of vitamin D-related changes in the plasma electrolyte composition, followed by their use in the identifcation of certain disorders of calcium metabolism and/or evaluating the effectiveness of the therapy used in each individual case.

1. Stefan Pilzetall. Vitamin D testing and treatment: a narrative review of current evidence. Endocr Connect. 2019 Feb; 8 (2): R 27–R 43. DOI: 10.1530/EC-18–0432.

2. Kargina I.G., Shcherbak V.A. Modern ideas about the role of vitamin D. Russian Pediatric Journal. 2016; 19 (2): 103–105 (In Russ.). DOI: 10.18821/1560–9561–2016–19(2)-103–105.

3. Markus J Seibel Biochemical Markers of Bone Turnover Part I: Biochemistry and Variability. Clin Biochem Rev. 2005 Nov; 26 (4): 97–122.

4. Solomennikov A. V., Tyukavin A. I., Arseniev N. A. A new approach to the development of methods for personalized expert analysis of laboratory data. Meditsinskiy sovet = Medical Council. 2019; (6): 164–168. (In Russ.) DOI: https://doi.org/10.21518/2079–701X-2019–6–164–168

5. Khundmiri SJ, Murray RD, Lederer E.PTH and Vitamin D. Compr Physiol. 2016 Mar 15; 6 (2): 561–601. DOI: 10.1002/cphy.c140071.

6. Masheiko I.V. Biochemical markers for the evaluation of bone tissue remodeling osteopenia and osteoporosis. State Institution “Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine. 2017. № 2., 149–151(In Russ).

7. Francesca Posa Vitamin D Effects on Osteoblastic Differentiation of Mesenchymal Stem Cells from Dental Tissues. Stem Cells International. January 2016 (6): 1–9. DOI: 10.1155/2016/9150819