Radiоtherapy as salvage therapy for kaposiform hemangioendothelioma and giant angioma associated with Kasabach–Merritt phenomenon
R. I. Khabarova,
S. A. Kulyova,
S. V. Ivanova,
S. N. Novikov,
E. D. Gumbatova,
E. M. Senchurov,
E. A. Mikhailova,
K. M. Borokshinova https://doi.org/10.33667/2078-5631-2021-19-12-17
Abstract
The Kasabach–Merritt phenomenon is a rare thrombocytopenic consumption of coagulopathy that occurs against the background of such vascular anomalies as kaposiform hemangioendothelioma and giant angioma. Timely diagnosis and treatment of Kasabach–Merritt syndrome which includes therapy for vascular tumors and life‑threatening conditions are critical in resolving this rare vascular anomaly. The aim of the study is to analyze radiation therapy as salvage therapy for kaposiform hemangioendothelioma and giant angioma associated with the Kasabach–Merritt phenomenon.
About the Authors
R. I. Khabarova
National Medical Research Centre of Oncology n.a. N. N. Petrov
Russian Federation
Russian Federation
Khabarova Rina I., MD, pediatric oncologist of Pediatric Oncology Dept, postgraduate student of Scientifi Dept of Innovative Methods of Therapeutic Oncology and Rehabilitation
SPIN: 6824–8710
S. A. Kulyova
National Medical Research Centre of Oncology n.a. N. N. Petrov; Saint Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
Kulyova Svetlana A., DM Sci, head of Pediatric Oncology Dept, senior researcher at Scientifi Dept of Innovative Methods of Therapeutic Oncology and Rehabilitation, professor at Educational and Methodological Dept , head of Dept of Oncology, Pediatric Oncology and Radiation Therapy
SPIN: 3441–4820
S. V. Ivanova
National Medical Research Centre of Oncology n.a. N. N. Petrov; Saint Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
Ivanova Svetlana V., PhD Med, MD, pediatric oncologist of Pediatric Oncology Dept, researcher of Scientifi Dept of Innovative Methods of Therapeutic Oncology and Rehabilitation1 , associate professor at Dept of Oncology, Pediatric Oncology and Radiation Therapy.
SPIN: 9442–5015
S. N. Novikov
National Medical Research Centre of Oncology n.a. N. N. Petrov
Russian Federation
Russian Federation
Novikov Sergey N., DM Sci, head of Radiation Therapy Dept, head of Scientifi Dept, freelance researcher, professor
SPIN: 7346–0687
E. D. Gumbatova
National Medical Research Centre of Oncology n.a. N. N. Petrov
Russian Federation
Russian Federation
Gumbatova Elvira D., PhD Med, MD, pediatric oncologist of Pediatric Oncology Dept
SPIN: 6082–3330
E. M. Senchurov
National Medical Research Centre of Oncology n.a. N. N. Petrov
Russian Federation
Russian Federation
Senchurov Evgeny M., MD, pediatric oncologist of Pediatric Oncology Dept
E. A. Mikhailova
National Medical Research Centre of Oncology n.a. N. N. Petrov
Russian Federation
Russian Federation
Mikhailova Elena A., MD, pediatric oncologist of Pediatric Oncology Dept, post‑graduate student of Scientifi Dept of Innovative Methods of Therapeutic Oncology and Rehabilitation
K. M. Borokshinova
National Medical Research Centre of Oncology n.a. N. N. Petrov
Russian Federation
Russian Federation
Borokshinova Ksenia M., MD, pediatric oncologist of Pediatric Oncology Dept, post‑graduate student of Scientifi Dept of Innovative Methods of Therapeutic Oncology and Rehabilitation
References
1. Beth A. Consensus –Derived Practice Standards Plan for Complicated Kaposiform Hemangioendothelioma. А. Beth, С. Cameron, R. Leonardo et al. The Journal of Pediatrics. 2013. 163 (1). P: 285–291. DOI.org/10.1016/j.jpeds.2013.03.080.
2. Mitsuhashi N. Outcome of radiation therapy for patients with Kasabach–Merritt syndrome. N. Mitsuhashi., M. Furuta, H. Sakura et al. Department of Radiology and Radiation Oncology, Gunma University School of Medicine. 1998. 1. P: 50–56. DOI.org/10.1016/S 0360–3016(97)00140–5.
3. Mahajan P. Kasabach–Merritt Phenomenon: Classic Presentation and Management Options. P. Mahajan, J. Margolin, I. Iacobas. Clin Med Insights Blood Disord. 2017. 1. P: 1–5. DOI: 10.1177/1179545X17699849.
4. Leong E., Bydder S. Use of radiotherapy to treat life-threatening Kasabach–Merritt syndrome. J. Med. Imaging Radiat. Oncol. 2009. 53 (1). P: 87–91. DOI: 10.1111/j.1754–9485.2009.02042.
5. Yamamoto S. Successful low-dose radiotherapy treatment for Kasabach–Merritt syndrome. S. Yamamoto, K. Akiyama, R. Kaneko et al. Department of Pediatrics, Showa University Fujigaoka Hospital, Yokohama, Japan. 2016. 58 (10). P: 1084–1086. DOI.org/10.1111/ped.13083.
6. Malhotra Y. Congenital Kaposiform Hemangioendothelioma with Kasabach–Merritt Phenomenon Successfully Treated with Low-Dose Radiation Therapy. Y. Malhotra, C. Yang, J. Namara et al. Pediatric Dermatology. 2014. 31 (5). P: 595–598. DOI.org/10.1111/pde.12090.
Review
For citations:
Khabarova R.I., Kulyova S.A., Ivanova S.V., Novikov S.N., Gumbatova E.D., Senchurov E.M., Mikhailova E.A., Borokshinova K.M. Radiоtherapy as salvage therapy for kaposiform hemangioendothelioma and giant angioma associated with Kasabach–Merritt phenomenon. Medical alphabet. 2021;(19):12-17. (In Russ.) https://doi.org/10.33667/2078-5631-2021-19-12-17
Views:
529
Email this article 