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Modern ideas about lichen planus of vulva

https://doi.org/10.33667/2078-5631-2021-9-63-66

Abstract

Lichen planus (LP) is a T-cell-mediated inflammatory dermatosis with an unclear etiology that affects the skin, nails and mucous membranes. The article outlines modern ideas about lichen planus, affecting the vulva. The issues of etiopathogenesis, clinical picture, differential diagnosis of various forms of this dermatosis are considered. The histopathological picture of vulvar LPL is described in detail. Possible complications, including anatomical abnormalities of the vulvar architectonics and the risk of malignant transformation, are considered. Various methods of treatment for this disease, local treatment regimens are presented, an overview of systemic drugs is given, as well as alternative approaches to patient management.

About the Authors

S. I. Surkichin
Central State Medical Academy of the Administrative Department of the President of Russia, Moscow
Russian Federation

Surkichin Sergei I., PhD Med, associate prof. at Dept of Dermatovenereology and Cosmetology



I. A. Apolikhina
National Medical Research Centre for Obstetrics, Gynecology andPerinatology n. a. academician V. I. Kulakov, Moscow
Russian Federation

Apolikhina Inna.A., DM Sci, prof.



R. Yu. Mayorov
Central State Medical Academy of the Administrative Department of the President of Russia, Moscow
Russian Federation

Mayorov Roman.Yu., resident of Dept of Dermatovenereology and Cosmetology



M. Avin
Medical Center ‘Stolitsa’, Moscow
Russian Federation

Marika Avin, dermatovenerologist



References

1. Machin SE, McConnell DT, Adams JD. Vaginal lichen planus: Preservation of sexual function in severe disease. BMJ Case Rep. 2010; 2010 pii: bcr0820092208.

2. Day T, Weigner J, Scurry J. Classic and hypertrophic vulvar lichen planus. J Low Genit Tract Dis. 2018; 22: 387–95.

3. Mahajan R, Jain V, Ninama K, Marfatia YS. Hypertrophic lichen planus of the vulva – A missed diagnosis. Indian J Sex Transm Dis AIDS. 2020; 41 (1): 116–118. DOI: 10.4103/ijstd.IJSTD_51_19.

4. Chew A, Stefanato C, Savarese I, et al. Клинические особенности плоского лишая у пациенток с плоским лишаем вульвы. Br J Дерматол 2014; 170: 218–20.

5. Goldstein A, Metz A. Vulvar lichen planus. Clin Obstet Gynecol 2005; 48: 818–23.

6. All-Russian public organization «Russian society of dermatovenerologists and cosmetologists». Clinical guidelines, 2020.

7. Bermejo-Fenoll A, López-Jornet P. Familial oral Lichen Planus: presentation of six families. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology. 2006; 102 (2): e12–e15.

8. Singal A. Familial mucosal Lichen Planus in three successive generations. International Journal of Dermatology. 2005; 44 (1): 81–82.

9. Gorouhi F, Davari P, Fazel N. Cutaneous and mucosal lichen planus: a comprehensive review of clinical subtypes, risk factors, diagnosis, and prognosis. ScientificWorldJournal. 2014; 2014: 742826. Published 2014 Jan 30. DOI: 10.1155/2014/742826.

10. Girardi C, Luz C, Cherubini K, Figueiredo MAZD, Nunes MLT, Salum FG. Salivary cortisol and dehydroepiandrosterone (DHEA) levels, psychological factors in patients with oral lichen planus. Archives of Oral Biology. 2011; 56 (9): 864–868.

11. Gupta R, Bansal B, Singh S, Yadav I, Gupta K, Kudesia M. Lichen planus of uterine cervix – the first report of a novel site of occurrence: a case report. Cases J. 2009; 2:9306. Published 2009 Dec 11. DOI: 10.1186/1757–1626–2–9306.

12. Day T, Weigner J, Scurry J. Classic and Hypertrophic Vulvar Lichen Planus. Low Genit Tract Dis. 2018; 22 (4): 387–395. DOI: 10.1097/LGT.0000000000000419.

13. Mauskar M. Erosive Lichen Planus. Obstet Gynecol Clin North Am. 2017 Sep; 44 (3): 407–420. DOI: 10.1016/j.ogc.2017.04.004. PMID: 28778640.

14. Simpson RC, Thomas KS, Leighton P, Murphy R. Diagnostic criteria for erosive lichen planus affecting the vulva: an international electronic-Delphi consensus exercise. Br J Dermatol. 2013; 169 (2): 337–343. DOI: 10.1111/bjd.12334.

15. Lewis FM. Vulval lichen planus. Br J Dermatol. 1998; 138: 569–75.

16. Kirtschig G, Wakelin SH, Wojnarowska F. Mucosal vulval lichen planus: outcome, clinical and laboratory features. JEAVD. 2005; 19: 301e7.

17. Halonen P, Jakobsson M, Heikinheimo O, Riska A, Gissler M, Pukkala E. Cancer risk of Lichen planus: A cohort study of 13,100 women in Finland. Int J Cancer. 2018 Jan 1; 142 (1): 18–22. DOI: 10.1002/ijc.31025. Epub 2017 Sep 8. PMID: 28857160.

18. Tjalma WA, Siozopoulou V, Huizing MT. A clitoral verrucous carcinoma in an area of lichen planus has aggressive features. World J Surg Oncol. 2017; 15 (1): 7. Published 2017 Jan 6. DOI: 10.1186/s12957–016–1069–0.

19. Meeuwis KA, de Hullu JA, Inthout J, et al. Genital Psoriasis Awareness Program: Physical and Psychological Care for Patients with Genital Psoriasis. Acta Derm Venereol. 2015; 95: 211–216.

20. Hoang MP, Reuter J, Papalas JA, et al. Vulvar inflammatory dermatoses: an update and review. Am J Dermatopathol. 2014; 36: 689–704.

21. Kalb RE, Bagel J, Korman NJ, et al. Treatment of intertriginous psoriasis: from the Medical Board of the National Psoriasis Foundation. J Am Acad Dermatol.2009; 60: 120–4.

22. Fistarol SK, Itin PH. Diagnosis and treatment of lichen sclerosus: an update. Am J Clin Dermatol. 2013; 14 (1): 27–47.

23. Moyal-Barracco M, Wendling J. Vulvar dermatosis. Best Pract Res Clin Obstet Gynaecol. 2014 Oct; 28 (7): 946–58.

24. Doyen J, Demoulin S, Delbecque K, et al. Vulvar skin disorders throughout lifetime: about some representative dermatoses. Biomed Res Int. 2014. 595286.

25. Li Q, Leopold K, Carlson JA. Chronic vulvar purpura: persistent pig-mented purpuric dermatitis (lichen aureus) of the vulva or plasma cell (Zoon’s) vulvitis? J Cutan Pathol. 2003; 30: 572–6.

26. Selim MA, Hoang MP. A Histologic review of vulva inflammatory dermatoses and intraepithelial neoplasm. Dermatol Clin. 2010; 28: 649–67.

27. Cooper SM, Wojnarowska F. Anogenital: Non-venereal disease. In: Jorizzo JL, Rapini RP, Bolognia JL, et al., editors. Dermatology. 2nd ed. Spain: Mosby, Elsevier; 2008. pp. 1061–62.

28. Fruchter R, Melnick L, Pomeranz MK. Lichenoid vulvar disease: A review. Int J Womens Dermatol. 2017; 3: 58–64.

29. Fahy CMR, Torgerson RR, Davis MDP. Lichen planus affecting the female genitalia: a retrospective review of patients at Mayo Clinic. J Am Acad Dermatol. 2017; 77 (6): 1053–1059. DOI: 10.1016/j.jaad.2017.07.030.

30. Cline A, Cuellar-Barboza A, Jorizzo JL, Pichardo RO. Methotrexate for the Treatment of Recalcitrant Erosive Lichen Planus of the Vulva. JAMA Dermatol. 2020; 156 (2): 215–217. DOI: 10.1001/jamadermatol.2019.4062

31. Helgesen AL, Warloe T, Pripp AH, Kirschner R, Peng Q, Tanbo T, Gjersvik P. Vulvovaginal photodynamic therapy vs. topical corticosteroids in genital erosive lichen planus: a randomized controlled trial. Br J Dermatol. 2015 Nov; 173 (5): 1156–62. DOI: 10.1111/bjd.14033. Epub 2015 Oct 16. PMID: 26189484


Review

For citations:


Surkichin S.I., Apolikhina I.A., Mayorov R.Yu., Avin M. Modern ideas about lichen planus of vulva. Medical alphabet. 2021;(9):63-66. (In Russ.) https://doi.org/10.33667/2078-5631-2021-9-63-66

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ISSN 2078-5631 (Print)
ISSN 2949-2807 (Online)