Clinical and epidemiological characteristics of catheter-associated bloodstream infections in patients with hematological profile
https://doi.org/10.33667/2078-5631-2020-34-9-12
Abstract
Patients with hemoblastosis, especially recipients of hematopoietic stem cells, are the most immunocompromised group of patients, especially during prolonged episodes of drug-associated granulocytopenia. The aim of the study. To characterize catheter-associated bloodstream infections in patients with hematological profile. Materials and methods. During June to October 2017, catheter-associated bloodstream infections were detected in six patients in the oncogematology department. Results and discussion. All patients came from different regions of the Russian Federation. The diagnosis of infectious complication: catheter-associated bloodstream infection was established only in 33.3 %. When determining laboratory markers of sepsis, high numbers of procalcitonin were observed in 50.0 % of patients, presepsin in 100.0 The growth of the bacterium Burholderia cepacia was observed in both central venous catheters (CVCs) and blood taken from CVCs. Phentotypically, all isolated cultures of Burholderia cepacia can be divided into three types: pan-resistant; polyresistant; polyresistant, but keeping sensitivity to co-trimoxazole. Multilocus sequencing of their DNA was carried out. The same sequence type was found in four patients. Given that the patients came from different regions, had not previously been in the same medical organization, care for CVC in the department of oncogematology was carried out by the same medical staff it can be assumed that four cases were caused by the same hospital strain Burkholderia cepacia.
About the Authors
O. A. Orlova
National Medical and Surgical Centre n. a. N. I. Pirogov; National Research Centre for Epidemiology and Microbiology n. a. Honorary Academician N. F. Gamaleya; Central Research Institute of Epidemiology
Russian Federation
Moscow
Russian Federation
Moscow
T. A. Semenenko
National Research Centre for Epidemiology and Microbiology n. a. Honorary Academician N. F. Gamaleya; First Moscow State Medical University n. a. I. M. Sechenov
Russian Federation
Moscow
Russian Federation
Moscow
V. G. Akimkin
Central Research Institute of Epidemiology
Russian Federation
Moscow
Russian Federation
Moscow
N. A. Yumtsunova
National Medical and Surgical Centre n. a. N. I. Pirogov
Russian Federation
Moscow
Russian Federation
Moscow
References
1. Руководство воз по гигиене рук в здравоохранении, 2013 [доступ: 16 ноября 2019]. Адрес: https://kpfu.ru/portal/docs/F390949735/VOZ.i.ruki.pdf
2. Клинические рекомендации. Профилактика катетер-ассоциированных инфекций кровотока и уход за центральным венозным катетером (ЦВК). Москва, 2017 [доступ: 16 ноября 2019]. Адрес: http://nasci.ru/_resources/directory/313/common/KR_KAIK.pdf
3. Edwards J. R., Peterson K. D., Andrus M. L., Dudeck M. A., Pollock D. A., Horan T. C. National Healthcare Safety Network (NHSN) Report, data summary for 2006 through 2007, issued November 2008. American Journal of Infection Control. 2008; 36: 609–626.
4. Rosenthal V. D., Maki D. G., Mehta A., Alvarez-Moreno C., Leblebicioglu H., Higuera F. et al. International Nosocomial Infection Control Consortium report, data summary for 2002–2007, issued January 2008. American Journal of Infection Control. 2008; 36: 627–637.
5. Квашнина Д. В., Ковалишена О. В., Белянина Н. А. Комплексная клинико-этиологическая и эпидемиологическая характеристика катетер-ассоциированных инфекций кровотока. Медицинский альманах. 2017; 4 (49): 41–45.
6. Козлов Р. С., Голуб А. В. Катетер-ассоциированные инфекции кровотока: предупредить или лечить? Клиническая микробиология и антимикробная химиотерапия. 2010; 12 (1): 23–30.
7. Ройтберг Г. Е., Кондратова Н. В. Снижение частоты катетер-ассоциированных инфекций при внедрении комплексной программы безопасности катетеризации в многопрофильном стационаре. Успехи современной науки. 2016; 6 (4): 141–146.
8. Youssef A., Hafez H., Madney Y., Elanany M., Hassanain O., Lehmann L. E. et al. Incidence, risk factors, and outcome of blood stream infections during the first 100 days post-pediatric allogeneic and autologous hematopoietic stem cell transplantations. Pediatric Transplantation. 2019; 4: e13610.
9. Kikuchi M., Akahoshi Y., Nakano H., Ugai T., Wada H., Yamasaki R. et al. Risk factors for pre- and post-engraftment bloodstream infections after allogeneic hematopoietic stem cell transplantation. Transplant Infectious Disease. 2015; 17 (1): 56–65.
10. Mikulska M., Raiola A. M., Galaverna F., Balletto E., Borghesi M. L., Varaldo R. et al. Pre-Engraftment Bloodstream Infections after Allogeneic Hematopoietic Cell Transplantation: Impact of T Cell-Replete Transplantation from a Haploidentical Donor. Biology of Blood and Marrow Transplantation. 2018; 24 (1): 109–118.
11. Naoufel Madani, Victor D Rosenthal, Tarek Dendane, Khalid Abidi, Amine Ali Zeggwagh, Redouane Abouqal. Health-care associated infections rates, length of stay, and bacterial resistance in an intensive care unit of Morocco: Findings of the International Nosocomial Infection Control Consortium (INICC). International Archives of Medicine. 2009; 2: 29–36.
12. Квашнина Д. В., Ковалишена О. В., Сутырина О. М., Соловьева И. В., Белова И. В., Точилина А. Г. и др. Эпидемическое неблагополучие по катетер-ассоциированным инфекциям кровотока среди пациентов, получающих заместительную почечную терапию. Эпидемиология и вакцинопрофилактика. 2019; 18 (2): 52–61.
13. Дудукина Е. Инфекции, связанные с оказанием медицинской помощи: факторы риска, роль объектов больничной среды и «некритического» медицинского инструментария (на примере стетоскопов) в передаче от пациента к пациенту. Поликлиника. 2016; 1: 39–45.
14. Ольхова В. Л., Попов В. Е. Двенадцатилетний опыт использования имплантированных венозных порт-систем у детей с онкологическими заболеваниями в условиях многопрофильного стационара: одномоментное исследование. Онкопедиатрия. 2019; 6 (1): 45–52.
15. Francolini I., Donelli G. Prevention and control of biofilm based medical-device-ralated infections. FEMS Immunol. Med. Microbiol. 2010; 59: 227–238.
16. Ruhnke M., Arnold R., Gastmeier P. Infection control issues in patients with haematological malignancies in the era of multidrug-resistant bacteria. The Lancet. 2014; 15 (13): 606–619.
17. Клинические рекомендации. Рекомендации по профилактике инфекционных осложнений среди реципиентов трансплантации гемопоэтических стволовых клеток. Москва, 2017 [доступ 16 ноября 2019].
18. Адрес: http://nasci.ru/_resources/directory/313/common/FKR_Transpl_2017.pdf.
19. Araç E., Kaya Ş., Parlak E., Büyüktuna S. A., Baran A. İ., Akgül F. et al. Evaluation of Infections in Intensive Care Units: A Multicentre Point-Prevalence Study. Mikrobiyoloji bülteni. 2019; 53 (4): 364–373.
20. Rello J., Sarda C., Mokart D., Arvaniti K., Akova M., Tabah A. et al. Antimicrobial Stewardship in Hematological Patients at the intensive care unit: a global cross-sectional survey from the Nine-i Investigators Network. European Journal of Clinical Microbiology & Infectious Diseases. 2019; 9: DOI: 10.1007/s10096–019–03736–30.
21. Орлова О. А., Семененко Т. А., Акимкин В. Г. Сравнительный анализ эффективности использования бактериологических и молекулярно-биологических методов для оценки микробной обсемененности объектов внутрибольничной среды. Журнал микробиологии, эпидемиологии и иммунобиологии. 2019; 4: 73–78.
Review
For citations:
Orlova O.A., Semenenko T.A., Akimkin V.G., Yumtsunova N.A. Clinical and epidemiological characteristics of catheter-associated bloodstream infections in patients with hematological profile. Medical alphabet. 2020;(34):9-12. (In Russ.) https://doi.org/10.33667/2078-5631-2020-34-9-12
Views:
456
Email this article 