Role of micronutrient deficiency in development of heart disease in Graves’ disease
https://doi.org/10.33667/2078-5631-2020-19-70-76
Abstract
Purpose. To assess the contribution of impaired supply of the body with zinc, selenium and copper to the development of cardiovascular complications in patients with Graves’ disease (HD). Methods. The study included 113 women aged 25–60 years with a diagnosis of HD: 54.0 % (n = 61) with moderate thyrotoxicosis, 46.0 % (n = 52) with severe. The duration of the disease is 1–5 years. The control group consisted of 37 women 25–60 years old without thyroid pathology and cardiovascular complications (CVC). All patients were assessed: in the blood – the level of thyroid-stimulating hormone, free thyroxine, the concentration of antibodies to the thyroid-stimulating hormone receptor; in the hair – the concentration of zinc, selenium, copper; results of ultrasound examination of the thyroid gland, echocardiography, 24-hour monitoring of electrocardiography. Results. Selenium deficiency was found in AF in 70.9% of cases (n = 22), zinc in 77.4 % (n = 24), copper in 67.7 % (n = 21) of cases, in CHF, selenium deficiency in 76.9% (n = 40), zinc – 82.7 % (n = 43), copper – 76.9 % (n = 40). In the control group, selenium deficiency was detected in 15.5% (n = 6) (p = 0.01), zinc deficiency – in 27.0% (n = 10) (p = .01), copper deficiency – in 10.8 % (n = 4) (p = 0.01) cases. Using logistic regression, a diagnostic model and a table of CHF risk factors in points were compiled, taking into account the levels of selenium, zinc, copper in the hair. It is advisable to use the table in all patients with HD to determine the degree of risk of CHF; with an average and high risk of developing CHF, it is recommended to include preparations of selenium, zinc, copper in the treatment regimen for HD. Conclusion. The results obtained show that the deficiency of these microelements increases the likelihood of a severe course of HD, the development of CVO, and requires diagnosis and correction.
About the Authors
L. V. Kvitkova
Kemerovo State Medical University
Russian Federation
Kemerovo
Russian Federation
Kemerovo
D. S. Vinichenko
Kuzbass Clinical Hospital n.a. S.V. Belyaev
Russian Federation
Kemerovo
Russian Federation
Kemerovo
S. A. Smakotina
Kemerovo State Medical University
Russian Federation
Kemerovo
Russian Federation
Kemerovo
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For citations:
Kvitkova L.V., Vinichenko D.S., Smakotina S.A. Role of micronutrient deficiency in development of heart disease in Graves’ disease. Medical alphabet. 2020;1(19):70-76. (In Russ.) https://doi.org/10.33667/2078-5631-2020-19-70-76
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