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Ammonia level of capillary blood in patients with inflammatory bowel diseases and nonalcoholic fatty liver disease

https://doi.org/10.33667/2078-5631-2020-10-49-51

Abstract

The article demonstrates results of research of ammonia level in capillary blood in patients with inflammatory bowel diseases (IBD) depending on nonalcoholic fatty liver disease (NAFLD) presence. There is a trend in elevation of ammonia level in capillary blood in patients with IBD and NAFLD, especially if small intestine is affected.

About the Authors

M. F. Osipenko
Novosibirsk State Medical University
Russian Federation
Novosibirsk


Ya. A. Krasner
Novosibirsk State Medical University
Russian Federation
Novosibirsk


I. D. Borodin
Novosibirsk State Medical University
Russian Federation
Novosibirsk


V. D. Kholin
Novosibirsk State Medical University
Russian Federation
Novosibirsk


References

1. Tripathi A., Debelius J., Brenner D. A. et al. The gut-liver axis and the intersection with the microbiome // Nature Reviews of Gastroenterology and Hepatology – 2018. – Vol. 15, N 7. – P. 397–411.

2. Uesugi T., Froh M., Arteel G. E. et al. Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice. // Hepatology. – 2001. – Vol. 34. – P. 101–108.

3. Seki E., Schnabl B. Role of innate immunity and the microbiota in liver fibrosis: crosstalk between the liver and gut. // The Journal of Physiology. – 2012. – Vol. 590. – P. 447–458.

4. Konturek P. C., Harsch I. A., Konturek K. et al. Gut–Liver Axis: How Do Gut Bacteria Influence the Liver? // Medical Sciences (Basel). – 2018. – Vol. 6, N 3. – P. 79.

5. Habtension N., Davies F., Andreola K. et al. Early increase in ammonia is a feature of non-alcoholic fatty liver disease and the ammonia lowering drug, ornithine phenylacetate (OCR-002) prevents progression of fibrosis in a rodent model. // Journal of hepatology. – 2017. – Vol. 66, N 1. – P. S 170.

6. Shen T. C., Albenberg L., Bittinger K. Engineering the gut microbiota to treat hyperammonemia. // The Journal of Clinical Investigation. – 2015. – Vol. 125, N 7. – P. 2841–2850.

7. Miele L., Valenza V., La Torre G. et al. Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease // Hepatology. – 2009. – Vol. 49, N 6. – P. 1877–1887.

8. Wigg A. J., Roberts-Thomson I.C., Dymock R. B. et al. The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor α in the pathogenesis of non-alcoholic steatohepatitis // Gut. – 2001. – Vol. 48, N 2. – P. 206–211.

9. Michielan A., D'Incà R. Intestinal Permeability in Inflammatory Bowel Disease: Pathogenesis, Clinical Evaluation, and Therapy of Leaky Gut // Mediators of Inflammation. – 2015. – Vol. 2015. – P. 1–10.

10. Bargiggia S., Maconi G., Elli M. et al. Sonographic prevalence of liver steatosis and biliary tract stones in patients with inflammatory bowel disease: study of 511 subjects at a single center // Journal of Clinical Gastroenterology. – 2003. – Vol. 36, N 5. – P. 417–420.

11. Saroli Palumbo C., Restellini S., Chao C. Y. et al. Screening for Nonalcoholic Fatty Liver Disease in Inflammatory Bowel Diseases: A Cohort Study Using Transient Elastography // Inflammatory Bowel Diseases. – 2018. – Vol. 0. – P. 1–10.

12. Ивашкин В.Т, Шелыгин Ю.А, Халиф И. Л. и др. Клинические рекомендации Российской гастроэнтерологической ассоциации и ассоциации колопроктологов России по диагностике и лечению болезни Крона / В. Т. Ивашкин [и др.] // Колопроктология. – 2017. – № 2. – С. 7–29.

13. Ивашкин В.Т, Шелыгин Ю.А, Халиф И. Л. и др. Клинические рекомендации Российской гастроэнтерологической ассоциации и ассоциации колопроктологов России по диагностике и лечению язвенного колита // Колопроктология. – 2017. – № 1. – С. 6–30.

14. Ивашкин В.Т, Маевская М. В., Павлов Ч. С. и др. Клинические рекомендации по диагностике и лечению неалкогольной жировой болезни печени Российского общества по изучению печени и Российской гастроэнтерологической ассоциации // Гепатология. – 2016. – № 2. – С. 24–42.

15. Jalan R., de Chiara F., Balasubramaniyan V., et al. Ammonia produces pathological changes in human hepatic stellate cells and is a target for therapy of portal hypertension. // Journal of Hepatology. – 2016. – Vol. 64, N 4 – P. 823–833.

16. De Chiara F., Thomsen K. L., Habtesion A. et al. Ammonia Scavenging Prevents Progression of Fibrosis in Experimental Nonalcoholic Fatty Liver Disease. // Hepatology. – 2020. – Vol. 71, N 3. – P. 874–892.

17. Буеверов А. О. Аммиак как нейро- и гепатотоксин: клинические аспекты. // Медицинский совет. – 2015. – № 13, С. 80–84.

18. Gutiérrez-de-Juan V., López de Davalillo S., Fernán-dez-Ramos D. et al. A morphological method for ammonia detection in liver. // PLoS One. – 2017. – Vol. 12, N 3, published online e0173914.


Review

For citations:


Osipenko M.F., Krasner Ya.A., Borodin I.D., Kholin V.D. Ammonia level of capillary blood in patients with inflammatory bowel diseases and nonalcoholic fatty liver disease. Medical alphabet. 2020;(10):49-51. (In Russ.) https://doi.org/10.33667/2078-5631-2020-10-49-51

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ISSN 2078-5631 (Print)
ISSN 2949-2807 (Online)