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Therapeutic drug monitoring in Davydovsky Hospital: using HPLC–MS/MS method in practical healthcare

https://doi.org/10.33667/2078-5631-2019-4-35(410)-47-52

Abstract

There was shown that therapeutic drug monitoring by liquid tandem mass spectrometry is essential not only for the drugs with a narrow therapeutic window but also for “simple” medicines like anti‑hypertension and anticoagulant drugs. The examples of choosing an individual therapy and adjusting the drug dosage to eliminate side effects were given. The cases of solving non‑standard situations that arise during bioanalytical studies were considered.

About the Authors

T. A. Rodina
Municipal Clinical Hospital n. a. I. V. Davydovsky, Moscow
Russian Federation


E. S. Melnikov
Municipal Clinical Hospital n. a. I. V. Davydovsky, Moscow
Russian Federation


References

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2. Rodina TA, Mel’nikov ES, Dmitriev AI, Belkov SA, Sokolov AV, Arkhipov VV, Prokof’ev AB. Simultaneous determination of metoprolol and bisoprolol in human serum by HPLC–MS/MS for clinical drug monitoring. Pharmaceutical Chemistry Journal. 2018 Mar 1; 51 (12): 1111–8.

3. Родина ТА, Мельников ЕС, Белков СА, Данько АА, Соколов АВ, Прокофьев АБ. Терапевтический лекарственный мониторинг нифедипина методом ВЭЖХ–МС/МС при лечении артериальной гипертензии. Биомедицина. 2017 (4): 53–69.

4. Rodina TA, Mel’Nikov ES, Sokolov AV, Prokof’Ev AB, Arkhipov VV, Aksenov AA, Pozdnyakov DL. Rapid HPLC–MS/MS determination of carbamazepine and carbamazepine-10, 11-epoxide. Pharmaceutical Chemistry Journal. 2016 Sep 1; 50 (6): 419–23.

5. Rodina TA, Mel’nikov ES, Aksenov AA, Belkov SA, Sokolov AV, Prokof’ev AB, Ramenskaya GV. HPLC–MS/MS Method for Determining Dabigatran in Human Blood Serum. Pharmaceutical Chemistry Journal. 2018 Mar 1;51 (12): 1129–37.

6. Rodina TA, Mel’nikov ES, Aksenov AA, Belkov SA, Sokolov AV, Prokof’ev AB, Ramenskaya GV. Development of an HPLC–MS/MS Method for Quantitative Determination of Rivaroxaban in Human Blood Serum. Pharmaceutical Chemistry Journal. 2018 Jul 1; 52 (4): 372–7.

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Review

For citations:


Rodina T.A., Melnikov E.S. Therapeutic drug monitoring in Davydovsky Hospital: using HPLC–MS/MS method in practical healthcare. Medical alphabet. 2019;4(35):47-52. (In Russ.) https://doi.org/10.33667/2078-5631-2019-4-35(410)-47-52

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ISSN 2078-5631 (Print)
ISSN 2949-2807 (Online)