Optimization of treatment of recurrent vulvovaginal candidiasis
https://doi.org/10.33667/2078-5631-2019-2-14(389)-27-30
Abstract
The purpose of the study was to evaluate the efficacy of treatment of recurrent drug Orungamin depending on the time of occurrence of relapse.
Material and methods. 62 women with recurrent candida vulvovaginit is were examined and treated. The mean age of the patients was 35.6 ± 0.7 years. The main group consisted of 32 patients who in the premenstrual period 5 days before the expected date of menstruation were prescribed Orungamin 1 capsule (100 mg) twice a day (200 mg) for 3 days during three consecutive menstrual cycles. The comparison group included women receiving Orungamin three consecutive cycle 3 day 1 capsule (100 mg) 2 times a day, without regard to days of the menstrual cycle.
Results. Therapy with Orungamin 100 mg twice a day during the premenstrual period not only helped to increase the effectiveness of the treatment of relapses, but also the quality of life of patients.
About the Authors
L. V. Tkachenko
Volgograd State Medical University
Russian Federation
Volgograd
Russian Federation
Volgograd
N. I. Sviridova
Volgograd State Medical University
Russian Federation
Volgograd
Russian Federation
Volgograd
L. N. Bogatyryova
Ingush State University
Russian Federation
Magas
Russian Federation
Magas
I. A. Gritsenko
Volgograd State Medical University
Russian Federation
Volgograd
Russian Federation
Volgograd
References
1. Байрамова Г. Р., Прилепская В. Н. Кандидозная инфекция в акушерстве и гинекологии // Provisorum. — Том 1. —№ 3. 2002. — С. 20–21.
2. Дикке Г. Б. Патологические выделения из влагалища: диагностика и лечение // Доктор.Ру. 2018. № 6 (150). С. 26–29.
3. CDC. Vulvovaginal Candidiasis: 2015 sexually transmitted diseases treatment guidelines. — URL: www.cdc.gov/std/tg2015/candidiasis.htm.
4. Denning D., Kneale M., Rautemaa-Richardson R. et al. Globalburden of recurrent vulvovaginal candidiasis: A systemic review // Lancet. Infect. Dis. 2018.
5. Safavieh M., Coarsey C., Esiobu N. et al. Advances in Candida detection platforms for clinical and point-of-care applications // Crit. Rev. Biotechnol. 2017. Vol. 37. № 4. P. 441–458. [PMID: 27093473].
6. Sherrard J., Wilson J., Donders G. et al. 2018 European (IUSTI/WHO) International Union against sexually transmitted infections (IUSTI) World Health Organisation (WHO) guideline on the management of vaginal discharge//Int. J. STD. AIDS.2018. [Epub ahead of print][PMID: 30049258].
7. Vulvovaginal Candidiasis: 2015 sexually transmitteddiseases treatment guidelines. — URL: www.cdc.gov/std/tg2015/candidiasis.htm.
8. Lamont R. F., Sobel J. D., Akins R. A., Hassan S. S., Chaiworapongsa T., Kusanovic J. P. et al. The vaginal microbiome: new information about genital tract flora using mollecular based techniques. Br. J. Obstet. Gynecol. 2011; 118 (5): 533–49. DOI: 10.1111/j.1471–0528.2010.02840.x.
9. Mardh PA, TchoudomirovaК, Elshibly S, Hellberg D. Symptoms and sings in single and mixed genital infections. Int J Gyneco lObstet 1996, 63: 145–152.
10. Павлович С. А. Микробиология с вирусологией и иммунологией / С. А. Павлович. — Минск: «Вышейшая школа». — 2005. — С. 754–756.
11. Пестрикова Т. Ю., Юрасова Е. А., Котельникова А. В. Бактериальный вагиноз, сочетанный с цервицитом: эффективность лечения // Доктор.Ру. 2018. № 6 (150). С. 30–33.
12. Петерсен Э. Э.; Прилепская В. Н., ред. Инфекции в акушерстве и гинекологии. М.: МЕДпресс-информ; 2007. 352 с.
13. Sharma JB, Buckshee K, Gulati N. Oral ketoconazole and miconazol vaginal pessary treatment for vaginal candidosis. Aust NZJ Obstet Gynaecol 1991: 31: 276–278.
14. Sobel JD, Chaim W. Vaginal microbiology of women with acute recurrent vulvovaginal candidiasis. J Clin Micro bio 11996: 34: 2497–9.
15. Kukner S, Ergin T, Cicek N, Ugur M, Yesilyurt H, Gokmen J. Treatment of vaginitis. Int J Gynecol Obstet 1996: 52: 43–47.
16. Тихомиров А. Л., Олейник Ч. Г. Современное лечение кандидозного вульвовагинита. «РМЖ» № 6 2001 с. 227.
17. Л. В. Ткаченко, Н. Д. Углова, С. И. Жукова Эффективные схемы лечения острого и рецидивирующего кандидозного вульвовагинита // РМЖ, том 11, № 16, 2003.
Review
For citations:
Tkachenko L.V., Sviridova N.I., Bogatyryova L.N., Gritsenko I.A. Optimization of treatment of recurrent vulvovaginal candidiasis. Medical alphabet. 2019;2(14):27-30. (In Russ.) https://doi.org/10.33667/2078-5631-2019-2-14(389)-27-30
Views:
380
Email this article 