Three-phase scintigraphy in evaluation of preoperative chemotherapy of soft tissue sarcomas of extremities
https://doi.org/10.33667/2078-5631-2019-3-28(403)-33-38
Abstract
Purpose. To determine the diagnostic value of threephase scintigraphy in the evaluation of the preoperative chemotherapy of soft tissue sarcomas of the extremities on different diagnostic stages. Material and methods. We analyzed the data of 76 patients with extremity soft tissue sarcomas. The study included data from 28 patients who underwent three-phase scintigraphy with Technetril 99mTc. Scintigraphic data before and after neoadjuvation chemotherapy were analyzed in 16 patients, before and during chemotherapy — in 6 patients, only during chemotherapy — in 1 and only after all courses of chemotherapy — in 5 patients. Results. The sensitivity of the method (prediction of grade III–IV pathologic response) was 100 %, specificity (prediction of grade I–II pathologic response) was 87%. The predictive value of positive and negative results was 63 and 100%, respectively. Conclusion. A three-phase scintigraphy with Technetril 99mTc is a highly informative method for evaluating the effectiveness of preoperative chemotherapy in patients with sarcomas of soft tissues of the extremities.
About the Authors
Ya. A. Shchipakhina
National Medical Research Centre of Oncology n.a. N.N. Blokhin
Russian Federation
Moscow
Russian Federation
Moscow
A. S. Krylov
National Medical Research Centre of Oncology n.a. N.N. Blokhin
Russian Federation
Moscow
Russian Federation
Moscow
N. V. Kochergina
National Medical Research Centre of Oncology n.a. N.N. Blokhin
Russian Federation
Moscow
Russian Federation
Moscow
L. E. Rotobelskaya
National Medical Research Centre of Oncology n.a. N.N. Blokhin
Russian Federation
Moscow
Russian Federation
Moscow
A. B. Bludov
National Medical Research Centre of Oncology n.a. N.N. Blokhin
Russian Federation
Moscow
Russian Federation
Moscow
A. S. Nered
National Medical Research Centre of Oncology n.a. N.N. Blokhin
Russian Federation
Moscow
Russian Federation
Moscow
A. V. Fyodorova
National Medical Research Centre of Oncology n.a. N.N. Blokhin
Russian Federation
Moscow
Russian Federation
Moscow
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Review
For citations:
Shchipakhina Ya.A., Krylov A.S., Kochergina N.V., Rotobelskaya L.E., Bludov A.B., Nered A.S., Fyodorova A.V. Three-phase scintigraphy in evaluation of preoperative chemotherapy of soft tissue sarcomas of extremities. Medical alphabet. 2019;3(28):33-38. (In Russ.) https://doi.org/10.33667/2078-5631-2019-3-28(403)-33-38
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