Рак поджелудочной железы: повреждения генома и возможности персонализированной медицины
Аннотация
В статье представлен обзор результатов ряда исследований в области генетики рака поджелудочной железы (РПЖ). Описаны наиболее часто выявляемые дефекты в генах TP53, KRAS, TGFBR 2, PIK3CA, CDKN 2A, SMAD 4 и индуцируемые ими изменения основных сигнальных, а также некоторые иммунологические механизмы опухолевой прогрессии и метастазирования при РПЖ. В обзоре представлены возможности использования выявленных молекулярно-генетических особенностей для выбора новых мишеней для таргетной терапии этого злокачественного вида опухоли с целью повышения эффективности лечения больных РПЖ и дальнейшего развития персонализированной медицины.
Об авторах
Т. И. Романова
ФГБНУ «Научно-исследовательский институт терапии и профилактической медицины» Сибирского отделения Российской академии наук
Россия
Россия
И. Н. Григорьева
ФГАОУ ВО «Новосибирский национальный исследовательский государственный университет»
Россия
Россия
О. В. Ефимова
ФГБНУ «Научно-исследовательский институт терапии и профилактической медицины» Сибирского отделения Российской академии наук; ГБУЗ НО «Городская клиническая больница № 7»
Россия
Россия
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Рецензия
Для цитирования:
Романова Т.И., Григорьева И.Н., Ефимова О.В. Рак поджелудочной железы: повреждения генома и возможности персонализированной медицины. Медицинский алфавит. 2017;1(9):34-39.
For citation:
Romanova T.I., Grigoryeva I.N., Efimova O.V. Pancreatic cancer: genome damage and possibilities of personalized medicine. Medical alphabet. 2017;1(9):34-39. (In Russ.)
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