Dysfunctions of liver in patients with chronic acalculous cholecystitis and their correction

Abstract

The aim of the study: evaluation of liver function abnormalities in patients with chronic acalculous cholecystitis and their correction. Materials and methods: 101 patients with chronic acalculous cholecystitis were examined at the age of 45.47 ± 1.37 years; the comparison group consisted of 30 practically healthy people. Patients underwent a complex study of the organs of the hepatobiliary tract and esophagogastroduodenal zone using laboratory and instrumental diagnostic methods. Results: Transaminase values did not exceed the limits of reference indices; however they were significantly higher than in patients of the comparison group. The level of indices of cholestasis syndrome (alkaline phosphatase, gamma glutamyltranspeptidase, cholesterol) was significantly higher in the patients of the observation group and exceeded the reference values. instrumental diagnostic methods revealed an increase in the V fraction of bile in multifractional duodenal sounding and a slowdown in the excretion of radiopharmaceuticals in dynamic hepatoscintigraphy. To correct the revealed violations to the standard therapy of HNH, the drug ademethionine was added. Conclusions: the use of ademetionine in the complex therapy of patients with chronic acalculous cholecystitis with functional liver disorders had a positive therapeutic effect in the form of improved clinical, laboratory and instrumental indices.